2011, Number 4
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Acta Ortop Mex 2011; 25 (4)
Multicenter osteoblastic osteosarcoma in a preschooler. Case report
Bermúdez-Balbuena V, López-Durán A, Shalkow J, López-Marmolejo A, Isunza-Ramírez A
Language: Spanish
References: 16
Page: 232-235
PDF size: 105.18 Kb.
ABSTRACT
Osteoblastic osteosarcoma is the most frequent malignant bone neoplasia in pediatric patients. It accounts for 50% of primary bone tumors and the most frequent age at presentation is adolescence, particularly during the growth spurts. Cases of children younger than 8 years of age have been reported in the literature. The purpose of this article is to report the case of a male, 19 month-old patient with osteoblastic osteosarcoma of the left distal femur and proximal tibia. It is considered as a special case due both to the age at presentation and to the multicenter feature of the tumor. This suggests that this entity may be more aggressive and rapidly growing in younger children. At the National Pediatrics Institute, in 35 years we only had three cases of children younger than 5 years.
REFERENCES
Fajardo GA, Mejía AJ, Hernández CL y cols: Epidemiología descriptiva de las neoplasias malignas en niños. Rev Pan Salud Pub 1999; 6(2): 75-88.
Álvarez LA, García LY: Tumores óseos cartilaginosos en niños. Reporte epidemiológico de 20 años en nuestro hospital. Act Ortop Mex 2004; 18(5): 191-5.
Hsieh MY, Hung GY, Yen HJ, et al: Osteosarcoma in preadolescent patients. Experience in a single institute in Taiwan. J Chin Med Assoc 2009; 72: 455–61.
Heare T, Hensley MA, Dell’Orfano: Bone tumors osteosarcoma and Ewing’s sarcoma: S. musculoskeletal tumor program. University of Colorado. The Children’s Hospital, Denver, CO, USA. Curr Opin Pediatr 2009; 21(3): 365-72.
Mejía AJ y cols: Edad de aparición de los diferentes tumores malignos en la infancia. Rev Med IMSS 2005; 43(1): 25-37.
Estrada VE, Delgado CEA, Rico MG: Frecuencia de neoplasias óseas en niños: Instituto Nacional de Rehabilitación. Act Ortop Mex 2008; 22(4): 238-42.
Unni KK: Multicentric osteosarcoma. In: Unni KK: Dahlin’s bone tumors, General aspects and data on 11,087 cases, 5th ed. Philadelphia: Lippincott-Raven 1986: 166.
Buzzoni R, Della TS, Cortinovis D, et al: Case report of synchronous multicentric osteosarcoma and review of the literature: the importance of autopsy for diagnosis. Medical Oncology Unit B. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy 2005; 91(1): 90-2.
Bacci G, Fabbri N, Balladelli A, et al: Treatment and prognosis for synchronous multifocal osteosarcoma in 42 patients. Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy. J Bone Joint Surg Br 2006; 88(8): 1071-5.
Fitzgerald RH, Dahlin DC, Sim FH: Multiple metachronous osteogenic sarcoma. Report of twelve cases with two long-term survivors. J Bone Joint Surg 1973; 55A: 595–605.
Price CHG: Multifocal osteogenic sarcoma: report of a case. J Bone Joint Surg 1957; 39B: 524–33.
Parham DM, Pratt CB, Parvey LS, et al: Childhood multifocal osteosarcoma. Clinicopathologic and radiologic correlates. Cancer 1985; 55: 2653–8.
Foci A, Barile L: II sarcoma osteogénico sclerosante a localizazione multipla. Arch Putti Chir Organi Mov 1971; 26: 409.
Wong KF, Shu SJ, Luk IS, et al: Multicentric osteosarcoma presenting as retrobulbar mass: a diagnostic enigma. Department of Pathology, Queen Elizabeth Hospital, Hong Kong: Pediatr Blood Cancer 2006; 46(7): 815-9.
Sasaki K, Yasui N, Fujikawa K: Multicentric synchronous osteosarcoma: a case report with autopsy findings. Department of Orthopaedic Surgery, Sendai Self-Defense Force Hospital, Japan. J Orthop Sci 2000; 5(3): 302-6.
Brandal P, Bjerkehagen B, Bruland OS, et al: Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience. Montebello, Oslo, Norway. Acta Oncol 2009; 48(8): 1165-72.