2007, Number 01-02
<< Back Next >>
Medicina & Laboratorio 2007; 13 (01-02)
Síndrome hemorrágico causado por orugas de mariposas
Ángel MR, Campuzano MG, Vanegas AN
Language: Spanish
References: 34
Page: 67-74
PDF size: 1957.29 Kb.
ABSTRACT
Caterpillars or larvae forms of nocturnal butterflies are important from the medical and toxinologic point of view. Lesions caused by contact with these caterpillars are called «erucism», such as the hemorrhagic injuries caused by the
Lonomia species. In 1967, the first case of hemorrhagic syndrome associated with
Lonomia was reported in Venezuela; and there have been more than 2000 cases reported in South America since then. In Colombia, the presence of
Lonomia species was described, and in 2000, the first two cases of hemorrhagic syndrome were reported in Casanare. Pathogenicity of these insects is due to a tegument with multiple tubular bristles, containing venom which is released after the skin contact with the bristles. After the contact, local and hemorrhagic manifestations appear in 50% of the patients. Treatment of this type of poisoning includes local measures and the rapid administration of the specific antivenom. Therefore, it is important to consider the presence of this type of insects in certain territories of the country and report suspicious cases.
REFERENCES
Lisete M, Lorini C, Élio C. Aspectos Morfológicos de Lonomia obliqua Walker. Lepidoptera: Saturniidae. 2001; 30: 373-378. 2. Rubio GB. [Epidemiological surveillance of distribution of the caterpillar Lonomia obliqua Walker, 1855, in the State of Parana, Brazil]. Cad Saude Publica 2001; 17: 1036.
Veiga AB, Blochtein B, Guimaraes JA. Structures involved in production, secretion and injection of the venom produced by the caterpillar Lonomia obliqua (Lepidoptera, Saturniidae). Toxicon 2001; 39: 1343-1351.
Caovilla JJ, Barros EJ. Efficacy of two different doses of antilonomic serum in the resolution of hemorrhagic syndrome resulting from envenoming by Lonomia obliqua caterpillars: a randomized controlled trial. Toxicon 2004; 43: 811-818.
Ramos AT, Goncalves LR, Ribeiro OG, Rocha Campos AC, Sant’Anna OA. Effects of Lonomia obliqua (lepidoptera, saturniidae) toxin on clotting, inflammatory and antibody responsiveness in genetically selected lines of mice. Toxicon 2004; 43: 761-768.
Arocha-Pinango CL. [Fibrinolysis caused by contact with caterpillars: preliminary communication]. Acta Cient Venez 1967; 18: 136-139.
Novel Brito A. Estudio de un nuevo caso. Fibrinolisis inducida por contacto con orugas. Asamblea de la Sociedad Venezolana de Hematología. Maracaibo, Venezuela, 1981.
Arocha-Pinango CL, de Bosch NB, Torres A, Goldstein C, Nouel A, Arguello A, et al. Six new cases of a caterpillar-induced bleeding syndrome. Thromb Haemost 1992; 67: 402-407.
Fraiha-Neto H. Síndrome hemorrágico por contacto con larvas de Lonomia (Lepidoptera, saturniidae). In Instituto Eduardo Chagas, 50 años de contribución a las ciencias biológicas de la Medicina Tropical, vol. 44. Fundación de Servicios de Salud Pública, Belem 1986; 811-820.
Barrios E, Cartell A, Dalle Mulle L. Encuentro Nacional de Accidentes por Animales Pecohentos, Abstract Book. 1992; 36.
Couppie P, Marty C, Sainte-Marie D, Pradinaud R. [Poisonous caterpillars in French Guyana. 5 cases]. Ann Dermatol Venereol 1998; 125: 489-491.
Pineda D, Amarillo A, Becerra J, Montenegro G. Síndrome hemorrágico por contacto con orugas del género Lonomia (Saturnidae) en Casanare, Colombia: informe de dos casos. 2001; 21: 328-332.
Gamborgi GP, Metcalf EB, Barros EJ. Acute renal failure provoked by toxin from caterpillars of the species Lonomia obliqua. Toxicon 2006; 47: 68-74.
Arocha-Pinango CL, Guerrero B. Lonomia obliqua and haemorrhagic syndrome. Lancet 1999; 354: 1304.
Fritzen M, Schattner M, Ribeiro AL, Batista IF, Ventura J, Prezoto BC, et al. Lonomia obliqua venom action on fibrinolytic system. Thromb Res 2003; 112: 105-110.
Zannin M, Lourenco DM, Motta G, Dalla Costa LR, Grando M, Gamborgi GP, et al. Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, southern Brazil. Thromb Haemost 2003; 89: 355-364.
Guerrero Guerrero BA, Arocha-Pinango CL, Gil San Juan A. Lonomia achelous caterpillar venom (LACV) selectively inactivates blood clotting factor XIII. Thromb Res 1997; 87: 83-93.
Guerrero BA, Arocha-Pinango CL, Gil San Juan A. Degradation of human factor XIII by lonomin V, a purified fraction of Lonomia achelous caterpillar venom. Thromb Res 1997; 87: 171-181.
Guerrero B, Perales J, Gil A, Arocha-Pinango CL. Effect on platelet FXIII and partial characterization of Lonomin V, a proteolytic enzyme from Lonomia achelous caterpillars. Thromb Res 1999; 93: 243-252.
Prezoto BC, Maffei FH, Mattar L, Chudzinski-Tavassi AM, Curi PR. Antithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosis. Braz J Med Biol Res 2002; 35: 703-712.
Veiga AB, Pinto AF, Guimaraes JA. Fibrinogenolytic and procoagulant activities in the hemorrhagic syndrome caused by Lonomia obliqua caterpillars. Thromb Res 2003; 111: 95-101.
Reis CV, Farsky SH, Fernandes BL, Santoro ML, Oliva ML, Mariano M, et al. In vivo characterization of Lopap, a prothrombin activator serine protease from the Lonomia obliqua caterpillar venom. Thromb Res 2001; 102: 437-443.
Seibert CS, Oliveira MR, Goncalves LR, Santoro ML, Sano-Martins IS. Intravascular hemolysis induced by lonomia obliqua caterpillar bristle extract: an experimental model of envenomation in rats. Toxicon 2004; 44: 793-799.
Chudzinski-Tavassi AM, Alvarez Flores MP. Exploring new molecules and activities from Lonomia obliqua caterpillars. Pathophysiol Haemost Thromb 2005; 34: 228-233.
Donato JL, Moreno RA, Hyslop S, Duarte A, Antunes E, Le Bonniec BF, et al. Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin. Thromb Haemost 1998; 79: 539-542.
Chudzinski-Tavassi AM, Schattner M, Fritzen M, Pozner RG, Reis CV, Lourenco D, et al. Effects of lopap on human endothelial cells and platelets. Haemostasis 2001; 31: 257-265.
de Castro Bastos L, Veiga AB, Guimaraes JA, Tonussi CR. Nociceptive and edematogenic responses elicited by a crude bristle extract of Lonomia obliqua caterpillars. Toxicon 2004; 43: 273-278.
Reis CV, Andrade SA, Ramos OH, Ramos CR, Ho PL, Batista IF, et al. Lopap, a prothrombin activator from Lonomia obliqua belonging to the lipocalin family: recombinant production, biochemical characterization and structure-function insights. Biochem J 2006; 398: 295-302.
da CBGAI, da Silveira RB, Nader HB, Dietrich CP, Gremski W, Veiga SS. Identification and partial characterisation of hyaluronidases in Lonomia obliqua venom. Toxicon 2005; 45: 403-410.
6th Panamerican Congress on Animal, Plant and Microbial Toxins of the International Society on Toxinology, Panamerican Section. An international meeting on toxins as problems, tools and solutions. 21-26 September 1998. Margarita Island, Venezuela. Abstracts. Toxicon 2001; 39: 439-468.
Seibert CS, Oliveira MR, Goncalves LR, Santoro ML, Sano-Martins IS. Intravascular hemolysis induced by Lonomia obliqua caterpillar bristle extract: an experimental model of envenomation in rats. Toxicon 2004; 44: 793-799.
Duarte AC, Crusius PS, Pires CA, Schilling MA, Fan HW. Intracerebral haemorrhage after contact with Lonomia caterpillars. Lancet 1996; 348: 1033.
Reis CV, Portaro FC, Andrade SA, Fritzen M, Fernandes BL, Sampaio CA, et al. A prothrombin activator serine protease from the Lonomia obliqua caterpillar venom (Lopap) biochemical characterization. Thromb Res 2001; 102: 427-436.
Arocha-Pinango CL, Guerrero B. [Hemorrhagic syndrome induced by caterpillars. Clinical and experimental studies. Review]. Invest Clin 2003; 44: 155-163.
Da Silva WD, Campos CM, Goncalves LR, Sousa-e-Silva MC, Higashi HG, Yamagushi IK, et al. Development of an antivenom against toxins of Lonomia obliqua caterpillars. Toxicon 1996; 34: 1045-1049.