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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2008, Number 4

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Rev Esp Med Quir 2008; 13 (4)

A comparative study of efficacy among difenidol, ondansetron and metoclopramide to prevent and treat postoperative nausea and vomit in patients submitted to ear and mastoid surgery

González MEG, Delgado CMM, Alamilla RC, Trejo MJJ, Salazar JCM

Language: Spanish
References: 20
Page: 153-158
PDF size: 173.36 Kb.


ABSTRACT

Objective: To evaluate effectiveness of two therapeutic schemes to prevent postoperative nausea and vomit in patients who were subjected to hearing and mastoid’s surgery.
Material and methods: It was carry out a comparative study to determine effectiveness of difenidol vs ondansetron vs metoclopramide. Ninety patients sample were studied, both sex, from 20 to 50 years old, ASA scale 1 or 2, they were subjected to ear surgery and mastoid surgery under general anesthesia. The patients were randomized in three groups: group I, treated with metoclopramide 10 mg IV unique dose; second group treated with ondansetron 8 mg IV, and group III treated with difenidol 40 mg IV, 10 minutes before they were extubated.
Results: There was significant difference between difenidol versus metoclopramide and ondansetron in the handling of nausea. There was not significant difference about vomit effectiveness among the groups.
Conclusions: Difenidol is effective for the handling and control for nausea and vomit compared to metoclopramide or ondansetron during postoperative period.


REFERENCES

  1. Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment and prevention. Anesthesiology 2000;77:162-84.

  2. Jacob SW, Francone CA, Lossow WJ. Anatomía y fisiología humana. 4a ed. México: Nueva Editorial Interamericana, 1992;pp:499-500.

  3. Guyton AC, Hall JE. Tratado de fisiología médica. 9a ed. México: McGraw-Hill Interamericana, 1996;pp:922-3.

  4. Mehernoor FW. Náuseas y emesis posoperatorias. En: Sanley W. Clínicas de anestesiología de Norteamérica. 1ª ed. México: McGraw-Hill Interamericana, volumen III, 2002;pp:677-90.

  5. Andrews PL. Physiology of nausea and vomiting. Br J Anaesth 2002;69(Suppl. 1):2S-19S.

  6. McKenzie R, K Kovac A, O O’Connor T, Dunclaf D, et.al. Comparison of O Ondasetron versus placebo to prevent nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology 2003;78:21-28.

  7. Kenny GN. Risk factors for postoperative nausea and vomiting. Anaesthesia 2003;49(Suppl.):6-10.

  8. Parnass SM. Problemas terapéuticos en la unidad de cuidados postanestesia de cirugía ambulatoria. Anesthesiol Clin North Am 2002;2:375-94.

  9. Carroll NV, Miederhoff P, Cox FM, Hirsch JD. Post operative nausea and vomiting from outpatient surgery centers. Anesth Analg 2000;80:903-9.

  10. Litman RS, Wu CI, Catanzaro FA. O Ondansetron decreases emesis after tonsillectomy in children. Anesth Analg 2003;8:478-81.

  11. Carroll NV, Miederhoff P, Cox FM, Hirsch JD. Post operative nausea and vomiting from outpatient surgery centers. Anesth Analg 2000;80:903-9.

  12. Serrano MR, Luna CR. O Ondasetrón, metoclopramida, difenidol en la prevención del vómito y náusea postoperatoria en cirugía oftalmológica. Rev Mex Anestesiología 1999;21:2:99-102.

  13. Ranta P, Nuutinen L, Laitinen J. The role of nitrous oxide in postoperative nausea and recovery in patients undergoing upper abdominal surgery. Acta Anesthesiol Scand 2003;35:339-41.

  14. Rodrigo MR, Campbell RC, Chow J, Tong CK, et al. Ondansetron for prevention of postoperative nausea and vomiting following minor oral surgery: a double-blind randomized study. Anaesth Intensive Care 2000; 22:576-9.

  15. Carroll NV, Miederhoff P, Cox PM, Hirsch JD. Postoperative nausea and vomiting after discharge from outpatient surgery centers. Anesth Analg 2000;80:903-9.

  16. Ferrari LR, Danion JV. Metoclopramide reduces the incidence of vomiting after tonsillectomy in children. Anesth Analg 2002;75:351-4.

  17. Larijani GE, Gratz Y, Afshar M, Minassian S. Treatment of postoperative nausea and vomiting with O Ondansetron: a randomized, double blind comparison with placebo. Anesth Analg 2001;73:246-9.

  18. Camu F, Laurence MH, Verbessem: incidence and etiology of postoperative nausea and vomiting. Eur J Anesthesiol 2001;9(Suppl. 6):25-31.

  19. Watcha MF, Bras PJ, Cieslak GD, Pennant JH. The dose-response relationship of ondansetron in preventing postoperative emesis on pediatric patients undergoing ambulatory surgery. Anesthesiology 2003;82:47-52.

  20. Ferrari LR, Donlon JV. Metoclopromide reduces the incidence of vomiting after tonsillectomy in children. Anesth Analg 2000; 75:351-4.




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