medigraphic.com
Instituto Nacional de Salud Pública

2011, Number 3

<< Back Next >>

salud publica mex 2011; 53 (3)

Streptococcus pneumoniae serotypes isolated from the middle ear of Mexican children diagnosed with acute otitis media

Demóstenes Gómez-Barreto D, Espinosa MLE, López-Enríquez C, Rodríguez SR, Torre C

Language: English
References: 37
Page: 207-211
PDF size: 210.01 Kb.


ABSTRACT

Objective. The aim of this study was to identify the etiology and the serotypes of S. pneumoniae (Sp) in Mexican children with acute otitis media (AOM). Materials and Methods. The study includes samples from patients diagnosed with AOM at the Federico Gomez Children’s Hospital of Mexico (2002-2003), with positive culture for Sp bacteriologically confirmed in middle ear fluid obtained by tympanocentesis. All Sp were serotyped. A total of 138 samples from 135 children with AOM were included. Results. Sp was isolated in 72 samples from 70 children. Sixty (85.7%) were previously healthy and 10 (14.3%) were immunocompromised. The most common serotypes were 6B and 19F (16.67%), and 6 A, 14 and 23F (15.27%). Conclusion. The distribution of serotypes among the children with AOM in the study is similar to that reported in developing cities, and 63.9% of the isolated serotypes are found to be included in the 7-Valent Pneumococcal Conjugate Vaccine (PCV), 68.1% in the 10-Valent PCV and 83.3% in 13-Valent PCV.


REFERENCES

  1. Jacobs MR. Increasing antibiotic among otitis media pathogens and their susceptibility to oral agents base on pharmacodynamic parameters. Pediatr Infect Dis J 2000; 19: S47-56.

  2. Black S, Shinefield H, Fireman B, Lewis E, Ray P, Hansen JR, et al. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group. Pediatr Infect Dis J 2000;19(3):187-95.

  3. Eskola J, Kilpi T, Palmut A, Jokinen J, Haapakoski J, Herva E, et al. Efficacy of pneumococcal conjugate vaccine against acute otitis media. N Engl J Med 2001; 344: 403-9.

  4. Centers for Disease Control and Prevention. Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1997;46:1-24.

  5. McCraken GH Jr. Treatment of acute otitis media in an era of increasing microbial resistance. Pediatr Infect Dis J 1998; 17:576-9.

  6. Klein JO. Microbiologic efficacy of antibacterial drugs for acute otitis media. Pediatr Infect Dis J 1993;12: 973-5.

  7. Teele DW, Klein JO, Word BM, Rosner BA, Starobin S, Earle R Jr, Ertel CS, Fisch G, Michaels R, Heppen R, Strause NP; Greater Boston Otitis Media Study Group. Antimicrobial prophylaxis for infants at risk for recurrent acute otitis media. Vaccine 2000; 19 Suppl 1:S140-3.

  8. Rodríguez RS, Sánchez C, de la Torre GC. Bacteriology and the response to treatment using erythromycin – sulphametoxazol in children with acute otitis media. Bol Med Hosp Infant Mex 1987; 44: 728.

  9. Owen J. Otitis media . N Engl J Med 2002; 347: 1169-74.

  10. Hausdorff WP, Bryant J, Kloek C, Paradiso PR, Siber GR. The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use: part II. Clin Infect Dis 2000; 30: 122-40.

  11. Facklam, RR and Washington JA II. Streptococcus and related catalasenegative gram-positive cocci. In: Ballows A, Hauher WJ, Hermann KL, Isenberg HD, and Shadomy HJ (ed). Manual of clinical microbiology. 5th ed. Washington, DC: American Society for Microbiology, 1991: 238-257

  12. Sørensen UB. Typing of pneumococci by using 12 pooled antisera. J Clin Microbiol 1993; 31(8):2097-100.

  13. Teele DW, Klein JO, Chase C, Menyuk, Rosner BA. Otitis media in infancy and intellectual ability, school achievement, speech, and language at age 7 years. Greater Boston Otitis Media Study Group. J Infect Dis 1990; 162(3): 685-94.

  14. Erhardt W, Murphy M, Knirsch C. Establishing criteria for assessment of efficacy of antimicrobial agents in acute otitis media. Antimicrob Agents Chemother 2000 ;44(9):2590-2.

  15. Leibovitz E, Serebro M, Givon-Lavi N, Greenberg D, Broides A, Leiberman A et al. Epidemiologic and microbiologic characteristics of culture-positive spontaneous otorrhea in children with acute otitis media. Pediatr Infect Dis J 2009;28(5):381-4

  16. Berman S. Otitis media in developing countries. Pediatrics 1995;96:126-31.

  17. Block SL, Hendrick J, Harrison CJ, Tyler R, Smith A, Findlay R, Keegan E. Pneumococcal serotypes from acute otitis media in rural Kentucky. Pediatr Infect Dis J 2002; 9:859-965.

  18. Hausdorff WP, Yorhers G, Dagan R, Kilpi T, Pelton SI, Cohen R, et al. Multinational Study of pneumococcal serotypes causing acute otitis media in children. Pediatr Infect Dis J 2002; 21: 1008-16.

  19. Hausdorff WP, Bryant J, Kloek C, Paradiso PR, Siber GR. The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II. Clin Infect Dis 2000; 30: 122-40.

  20. Dagan R, Givon, Lavi N, Shkolnik L, Yagupsky P, Fraser D. Acute otitis media caused by antibiotic-resistant Streptococcus pneumoniae in southern Israel: implication for immunizing with conjugate vaccines. J Infect Dis 2000;18: 1322-29.

  21. Guevara S, Soley C, Arguedas A, Porat N, Dagan R.Seasonal distribution of otitis media pathogens among Costa Rican children. Pediatr Infect Dis J 2008; 27(1):12-6

  22. Rodgers GL, Arguedas A, Cohen R, Dagan R. Global serotype distribution among Steptococcus pneumoniae isolates causing otitis media in children: potential implications for pneumococcal conjugate vaccines. Vaccine 2009; 27: 3802-10.

  23. Arguedas A, Dagan R, Guevara S, Porat N., Soley C, Pérez A, Brilla R. Middle era fluid Streptococcus pneumoniae serotype distribution in Costa Rican children with otitis media. Pediatr Infec Dis J 2005; 24: 631-34.

  24. Prymula P, Peeters P, Chrobok V, Kriz P, Novakova E, Kohl I, et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non- typable Haemophilus influenzae: a randomized double -blind efficacy study. Lancet 2006; 367: 270-78.

  25. Kilpi T , Herva E, Kaijalainen T, Syrjânen R, Takala AK. Bacteriology of acute otitis media in a cohort of Finnish children followed for the first two years of life. Pediatr Infec Dis J 2001; 20: 654-62.

  26. Gene A, Garcia-Garcia JJ, Domingo A, Wiemberg P, Palavacino E. Etiology of acute otitis media in children in hospital and sensitivity of the evolved microorganisms to antibiotics: Enferm Infect Microbiol Clin 2004; 22: 377-30.

  27. Block SL, Hedrick J, Harrison CJ, Tyler R, Smith A, Findlay R, et al. Community-wide vaccination with the heptavalent pneumococcal conjugate significantly alters the microbiology of acute otitis media. Pediatr Infect Dis J 2004;9:829-33.

  28. Casey JR, Pichichero ME. Changes in frequency and pathogens causing acute otitis media in 1995 -2003. Pediatr Infect Dis J 2004;23:824-28.

  29. Zhou F, Shefer A, Kong Y, Nuorti JP. Trends in acute otitis media – related health care utilization by privately insured young children in the United States, 1997-2004. Pediatrics 2008; 121: 253-60.

  30. Pichichero ME, Casey JR. Emergence of multiresitant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA 2007; 298:1772-1778.

  31. Pai R, Moore MR, Pilishvili T, Gertz RE, Whitney CG, Beall B,. Active Bacterial Core Surveillance Team. Post vaccine genetic structure of Streptococcus pneumoniae serotype 19 A from children in the United States, J Infect Dis 2005. 192: 1988-95.

  32. McEllistrem MC, Adams JM, Patel K, Mendelsohn AB, Kaplan SL, Bradley JS et al. Acute otitis media due to penicillin –nonsusceptible Streptococcus pneumoniae before and after the introduction of the pneumococcal conjugate vaccine. Clin Infec Dis 2005; 40: 1738-44.

  33. Choi EH, Kim SH, Eun BW, Kim SJ, Kim NH, Lee J, et al. Streptococcus pneumoniae serotype 19A in children, South Korea. Emerg Infect Dis 2008;14(2):275-81.

  34. Espinosa-de Los Monteros LE, Jiménez-Rojas V, Aguilar-Ituarte F, Cashat-Cruz M, Reyes-López A, Rodríguez-Suárez R, Kuri-Morales P, Tapia-Conyer R, Gómez-Barreto D. Streptococcus pneumoniae isolates in healthy children attending day-care centers in 12 states in Mexico. Salud Publica Mex 2007; 49(4): 249-55.

  35. Gomez-Barreto D, Espinosa de los Monteros LE, Lopez-Enriquez C, Jimenez Rojas V, Rodriguez Suarez R. Invasive Pneumococcal Disease in a Third Level Pediatric Hospital in Mexico City: Epidemiological Characteristics and Mortality-Related Risk Factors. Salud Publica Mex 2010; 52 (5): 391-97.

  36. Porat N, Soley C, Marengoleine MM, Grenber D, Givon-Levin, Trefler R, et al. An international serotype 3 clones causing pediatric and invasive infections in Israel, Costa Rica and Lithuania. Pediatr Infec Dis J 2008; 27: 709-12

  37. Whitney CG, Farley MM, Hadler J, Harrison LH, Bennett NM, Lynfield R et al. Active Bacterial Core Surveillance of the Emerging Infections Program Network. Decline in invasive pneumococcal disease after the introduction of protein polysaccharide conjugate vaccine. N Engl J Med 2003; 348: 1733-45.




2020     |     www.medigraphic.com