2001, Number 3
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Med Sur 2001; 8 (3)
Cryoglobulinemia and hepatitis C. A case report
Méndez-Sánchez N, Pichardo-Bahena R, Uribe M
Language: Spanish
References: 11
Page: 90-92
PDF size: 37.83 Kb.
ABSTRACT
The viral hepatitis C (VHC) is a systemic illness. Although the major manifestations are usually related to the liver. Due to the large evolution of illness and the VHC has an unusual characteristic to trigger autoimmune disorders, the development of extrahepatic clinical manifestations are frequents. The pathogenesis of cryoglobulinemia it’s related with de formation of immunoglobulins complex which precipitates in vitro at low temperatures. The cryoglobulinemia are the more frequent illness associated at VHC, are present in 80% of patients with HCV. The cryoglobulinemia are clinically characterized principally for purpuric skin lesions, fatigue and arthralgias, among others. These clinically manifestations may be the pivotal sign of VHC. In this article are presented a case of woman with VHC with extrahepatic clinically manifestations, with emphasis in the recognizance and prognostic implications of the cryoglobulinemia.
REFERENCES
Agnello V. Mixed cryoglobulinemia and other extrahepatic manifestations of hepatitis C virus infection. In: Hepatis C. Liang TJ, Hoofnagle JH, Editors. Academic Press, San Diego, California, 2000, pp 295-313.
Schott P, Hartmann H, Ramadori G. Hepatitis C virus-associated mixed cryoglobulinemia. Clinical manifestations, histopathological changes, mechanisms of cryoprecipitation and options of treatment. Histol Histopathol 2001; 16: 1275-85.
Brouet JC, Clauvel JP, Danon F, Klein M, Seligmann M. Biologic and clinical significance of cryoglobulins. A report of 86 cases. Am J Med 1974; 57: 775-88.
Monti G, Galli M, Invernizzi F, Pioltelli P, Saccardo F, Monteverde A, Pietrogrande M, Renoldi P, Bombardieri S, Bordin G et al. Cryoglobulinaemias: a multi-centre study of the early clinical and laboratory manifestations of primary and secondary disease. GISC. Italian Group for the Study of Cryoglobulinaemias. QJM 1995; 88: 115-26.
Meltzer M, Franklin EC, Elias K, McCluskey RT, Cooper N. Cryoglobulinemia-a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity. Am J Med 1966; 40: 837-56.
Agnello V. The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection. Springer Semin Immunopathol 1997; 19: 111-29.
Agnello V. Hepatitis C virus infection and type II cryoglobulinemia: an immunological perspective. Hepatology 1997; 26: 1375-9.
Agnello V. Mixed cryoglobulinaemia after hepatitis C virus: more and less ambiguity. Ann Rheum Dis 1998; 57: 701-2.
Schmidt1 WN, Stapleton JT, LaBrecque DR, Mitros FA, Kirby PA, Phillips MJP, Brashear DL. Hepatitis C virus (HCV) infection and cryoglobulinemia: analysis of whole blood and plasma HCV-RNA concentrations and correlation with liver. Histology Hepatology 2000; 31: 737-744.
Lunel F, Cacoub P. Treatment of autoimmune and extrahepatic manifestations of hepatitis C virus infection. J Hepatol 1999; 31(Suppl. 1): 210-216.
Schalm SW, Brouwer JT, Bekkering FC, van Rossum TG. New treatment strategies in non-responder patients with chronic hepatitis C. J Hepatol 1999; 31(Suppl. 1): 184-188.