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Instituto Nacional de Neurología y Neurocirugía

2011, Number 1

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Arch Neurocien 2011; 16 (1)

Interacción entre los factores neurotróficos y las especies reactivas de oxígeno en los mecanismos de muerte y proliferación celular

Castillo-Padilla DV, Rivas-Arancibia S

Language: Spanish
References: 77
Page: 26-32
PDF size: 167.04 Kb.


ABSTRACT

The loss in the redox balance involved an uncontrolled increase in reactive oxygen species (ROS), which participates in the signaling of cell death due to oxidative stress in different types of tissues, including neurons. On the other hand, neurotrophic factors play an important role in the survival and proliferation of neurons. Recently, an interaction has been described between growth factors and ROS in the functioning of cells. The receptors of some trophic factors can be phosphorilated by ROS, which modulate the molecular cascades activated by those receptors. Also, growth factors may induce the production of ROS within the cell. Some growth factors could produce cell death. Moreover, a pattern of convergent signaling has been recently discovered between ROS and some trophic factors regulating survival, proliferation or cell death responses. Dysregulation in trophic factors signaling and the exposure to prolonged low levels of ROS may generate a decontrolled cell proliferation, thus promoting cancer in different tissues, including nervous system. This suggests the synchronized activation between ROS and growth factors is necessary to maintain the cellular homeostasis. In this work, we reviewed studies about the interaction between molecular signaling of neurotrophic factor and ROS.


REFERENCES

  1. Lindsay RM. Brain-derived neurotrophic factor: An NGF-related neurotrophin, in Loughlin S, Fallon J (Eds): Neurotrophic Factors. San Diego, Calif, Academic Press, 1993. pp 257-284.

  2. Hefti F. Pharmacology in neurotrophic factors. Annu Rev Pharmacol 1997; 37: 239-67.

  3. Levi-Montalcini R, Hamburger, V. Selective growth stimuli effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J experim zool 1951; 116: 321-61.

  4. Barde YA, Edgar D, Thoenen H. Purification of a new neurotrophic factor for mammalian brain. EMBO 1982; 1: 549-53.

  5. Ernfors P, Ibáńez CF, Ebendal T, Olson L, Persson H. Molecular cloning and neurotrophic activities of a protein whit structural similarities to nerve growth factor: developmental and topographical expression in the brain. PNAS 1990; 87: 5454-8.

  6. Hallbröök F, Ibáńez CF, Persson H. Evolutionary studies of the growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 1991; 6: 845-58.

  7. Götz R, Köster R, Winkler C, Lottpeich F, Schartl M, Thoenen H. Neurotrophin-6 is a new member of the nerve growth factor family. Nature 1994; 362: 266-9.

  8. Nilsson AS, Fainzilber M, Falck P, Ibáńez CF. Neurotrophin-7: a novel member of the neurotrophin family from the zebrafish. FEBS Lett 1998; 424: 285-90.

  9. Minichiello L. TrkB signaling pathways in LTP and learning. Nat Rev Neurosci 2009; 10: 850-60.

  10. Teng KK, Hempstead BL. Neurotrophins and their receptors: signaling trios in complex biological system. Cell Mol Life Sci 2004, 61: 35-48.

  11. Franke TF, Kaplan DR, Cantley LC. PI3-K AKTion block apoptosis. Cell 1997; 88: 435.

  12. Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, et al. Induction of proneurotrophins and activation of p75NTR mediated apoptosis via neurotrophin receptor interacting factor (NRIF) in hippocampal neurons after seizures. J Neurosci 2008; 28: 9870-9.

  13. Gómez-Pinilla F, Knauer DJ, Nieto-Sampedro M. Epidermal growth factor immunoreactivity in the rat brain. Development and cellular localization. Brain Res 1998; 498: 385-90.

  14. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z, Derynck R. Epithelial immaturity multiorgan failure in mice lacking epidermal growth factor receptor. Nature 1995;376:337-41.

  15. Fallon JH, Seroogy KB, Loughlin SA, Morrison RS, Bradshaw RA, Knaver DJ, et al. Epidermal growth factor immunoreactive material in the central nervous system: location and development. Science 1984; 224: 1107-9.

  16. Bazley LA, Gullick WJ. The epidermal growth factor receptor family. Endocr Rel Cancer 2005; 12: S17-S27.

  17. Yamada M, Ikeuchi T, Hatanaka H. The neurotrophic action and signalling of epidermal growth factor. 1997. Prog Neurobiol 51; 19-37.

  18. Sánchez-González P, Jallali K, Villalobo A. Calmodulin-mediated regulation of epidermal growth factor. FEBS J 2010; 277: 327-42.

  19. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 2001, 3: 802-8.

  20. Morrison RS, Sharma A, de Vellis J, Bradshaw RA. Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. PNAS 1986, 83: 7537-41.

  21. Hall H, Williams EJ, Moore SE, Walsh FS, Prochiantz A, Doherty P. Inhibition of FGF-stimulated phophatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide. Curr Biol 1996; 580-7.

  22. Dono R. Fibroblast growth factor as regulators of central nervous system development and function. Am J Physiol Regul Integr Comp Physiol 2003; 284: R867-81.

  23. Iwata T, Hevner RF. Fibroblast growth factor signaling in development of the cerebral cortex. Dev Growth Diffe 2009; 51: 299-323.

  24. Mason I. Initiation to end point: the multiple roles of fibroblastic growth factors in neural development. Nat Rev Neurosci 2007; 8: 583-96.

  25. Orniz DM, Itho M. Fibroblast growth factors. Genome Biol, 2001, 3005-1-3005-11.

  26. Knights V, Cook SJ. De-regulated FGF receptors as therapeutic targets in cancer. Pharmacol Ther 2010, 125: 105-117.

  27. Hall A, Glese NA, Richardson WB. Spinal cord oligodendrocytes develop ventrally derived progenitors cells that express PDGF alpha receptors. Development 1996; 122: 4085-94.

  28. Klint P, Cleasson Welsh. Signal Transduction by fibroblast growth factor receptor. Front Biosci 1999; 4: D165- 177.

  29. Lund PK, Moats-Staats BM, Haynes MA, Simmons JG, Jansen M, D´Ercole AJ, et al. Somatomedin-C/Insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues. J Biol Chem 1986; 261: 14540-14544.

  30. Lichtenwalner RJ, Forbes ME, Sonntag WE, Riddle DR. Adultonset deficiency in growth hormone and insulin-like growth factor-I decreases survival of dentate granule neurons: Insight into the regulation of adult hippocampal neurogenesis. J Neurosci Res 2006; 83: 199-210.

  31. Radcliff K, Tang TB, Lim J, Zhang Z, Abedin M, Demer L L, et al. Insulin-like growth factor I regulates proliferation and osteoblastic differentiation of calcifying vascular cells via extracellular signalregulated protein kinase and phosphatidylinositol 3-kinase pathways. Circulat Res 2005; 96: 398-40.

  32. Rotwein P, Burgess SK, Milsbrant JD, Krause JE. Differential expression of insulin-like growth factor genes in rat central nervous system. PNAS 1988; 85: 265-9.

  33. Giovannone B, Scaldaferri ML, Federeci M, Porzio O, Lauro D, Fusco A, et al. Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. Diabet Met Res Rev 2000; 16: 434-441.

  34. Bondy CA, Cheng CM. Signaling by insulin-like growth factor 1 in brain. Eur J Pharmacol 2004; 490:25-31.

  35. Choi YS, Cho HY, Hoyt KR, Naegele JR, Obrietan K. IGF-1 receptor mediated ERK/MAPK signaling couples status epileptics to progenitor cell proliferation in the sub granular layer of the dentate gyros. Glia 2008; 56: 791-800.

  36. D’Ercole AJ, Ye P, Calikoglu AS, Gutierrez-Ospina G. The role of the insulin-like growth factor in the central nervous system. Mol Neurobiol 1996; 13: 227-55.

  37. Bartosz G. Reactive oxygen species: Destroyers or messengers?. Biochem Pharmachol 2009; 77: 1303-15.

  38. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002; 192: 1-15.

  39. Dungan LL, Creedon DJ, Johnson EM, Holtzman M. Rapid suppression of free radical formation by nerve growth factor involves the mitogen-activated protein kinase pathway. PNAS 1997; 94: 4086-91.

  40. Satoh T, Sakai N, Enokido Y, Uchiyama Y, Hatanaka H. Free radical independent protection by nerve growth factor and Bcl-2 of PC12 cells from hydrogen peroxide-tiggered apoptorsis. J Biochem 1999; 120: 540-6.

  41. Wu A, Ying Z, Gómez-Pinilla F. Dietaryomega-3 fatty acids normalize BDNF level, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004; 21: 1457-67.

  42. Wu A, Ying Z, Gomez-Pinilla F. The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition. Eur J Neurosci 2004; 19: 1699-1707.

  43. Radak Z, Toldy A, Szabo Z, Siamilis S, Nyakas C, Jakus J, et al. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int 2006. 49: 387-92.

  44. Joosten EA, Houweling DA. Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and antioxidant effects. Neuroreport 2004; 15: 1163-1166.

  45. Kirschner PB, Jenkins BG, Schulz JB, Finkelstein SP, Matthews RT, Rosen BR, et al. NGF, BDNF and NT-3 protect against MPP+ toxicity and oxidative stress in neonatal animals. Brain Res 1996; 713: 178-85.

  46. Skaper SD, Negro A, Facci L, Del Toso R. Brain-derived neurotrophic factor selectively rescue mesencephalic dopaminergic neurons from 2,4,5- trihydroxyphenilalanine-induces injury. J Neurosci Res 1993; 34: 478-87.

  47. Olivieri G, Otten U, Meier F, Baysang G, Dimitriades-Schmutz B, Müller-Spahn F, et al. Oxidative stress modulates tyrosine kinase receptor A and p75 receptor (low-affinity nerve growth factor receptor) expression in SHSY5Y neuroblastoma cells. Neurol Clin Neurophysiol 2002; 2002: 2-10.

  48. Bedogni B, Pani G, Colavitti R, Riccio A, Borrello S, Murphy M, et al. Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor-dependent cell survival. J Biol Chem 2003; 278: 16510-16519.

  49. Dorrell MI, Aguilar E, Jacobson R, Yanes O, Gariano R, Heckenlively J, et al. Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularizationassociated oxidative stress. J Clin Inves 2009; 119: 611-23.

  50. Knebel A, Rahmsdorf HJ, Ullrich A, Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO 1996; 15: 5314-25.

  51. Ravid T, Sweeney C, Gee P. Carraway KL, Goldkorn T. Epidermal growth factor receptor activation under oxidative stress fails to promote c-Cbl mediated down-regulation. J Biol Chem 2002; 277: 31214-9.

  52. Sachsenmaier C, Radler-Poh A, Zinck R. Nordheim A, Herrlich P, Rahmsdorf HJ. Involvement of growth factor receptors in the mammalian UVC response. Cell 1994; 963-72.

  53. Warmuth I, Harth Y, Matsui MS, Wang N, DeLeo VA. Ultraviolet radiation induces phosphorylation of the epidermal growth factor receptor. Cancer Res 1994; 54: 374-6.

  54. Coffer PJ, Burgering BM, Peppelenbosch MP, Bos JL, Kruiejer W. UV activation of receptor tyrosine kinase activity. Oncogene 1995;11: 561-9.

  55. Huang RP, Wu JX, Fan Y, Adamson ED. UV activates growth factor receptors via reactive oxygen intermediates. J Cell Biol 1996; 133: 211-20.

  56. Liu B, Neufeld AH. Activation of epidermal growth factor receptors in astrocytes: from development to neural injury. J Neurosci Res 2007; 85:3523-9.

  57. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995; 270: 296-9.

  58. Bae YS, Kang SW, Seo MS, Baines IC, Tekle E, Chock PB, et al. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J Biol Chem 1997; 272: 217-21.

  59. Papaconstantinou J. Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination. Mol Cell Endocrinol 2009;299: 89-100.

  60. Zhang L, Jope RS. Oxidative stress differentially modulates phosphorylation of ERK, p38 and CREB induced by NGF or EGF in PC12 cells. Neurobiol Aging 1999; 20: 271-8.

  61. Wang X, McCullough, Franket TF, Holbrook NJ. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 2000; 275: 14624-31.

  62. Levinthal DJ, De Franco DB. Transient phosphatidylinositol 3-kkinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signalregulated kinase activation. J Biol Chem 2004; 279:11206-13.

  63. Cha YK, Kim YH, Ahn YH, Koh JY. Epidermal growth factor induces oxidative neuronal injury in cortical culture. J Neurochem 2000; 75: 298-303.

  64. Lobner D, Liot G. Role of MAPK/ERK in neurotrophin-4 potentiation of necrotic neuronal death. Neurochem Res 2004; 29: 2303-9.

  65. Hwang JJ, Choi SY, Koh JY. The role of NADPH oxidase, neuronal nitric oxide synthase and poly(ADP ribose) polymerase in oxidative neuronal death induced in cortical cultures by brain-derived neurotrophic factor and neurotrophin-4/5. J Neurochem 2002; 82: 894-902.

  66. Noh KM, Lee JC, Ahn YH, Hong SH, Koh JY. Insulin-induced oxidative neuronal injury in cortical culture: mediation by induced N-methyl-D-aspartate receptors. IUBMB Life 1999; 48: 263-9.

  67. Van Gorp AGM, Pomeranz KM, Birkenkamp KU, Hui RCY, Lam EWF, Coffer PJ. Chronic Protein Kinase B (PKB/c-akt) Activation Leads to Apoptosis Induced by Oxidative Stress–Mediated Foxo3a Transcriptional Up-regulation. Cancer Res 2006; 66: 10760-9.

  68. Waterfield MD. Two distint mechanisms involving growth factors employed in subversion of growth regulation of oncogenes. Prog Med Virol 1985; 32: 129-41.

  69. Le Roith D. The insulin-like growth factor system. Exp Diabesity Res 2003. 205-12.

  70. Pillay V, Allaf L, Wilding AL, Donoghue JF, Court NW, Greenall SA, Scott AM, Johns TG. The plasticity of oncogene addiction: implications for targeted terapies directed to receptor tyrosin kinase. Neoplasia 2009; 11: 448-58.

  71. Thiele CJ, Li Z, MCkee AE. On Trk - the Trk signal transduction pathway is an increasengly important target in cancer biology. Clin Cancer Res 2009; 15: 5962-7.

  72. Federico A, Morgillo F, Tuccillo C, Ciardello F, Loguercio C. Chronic inflammation and oxidative stress in human carcinogenesis. Int J Cancer 2007; 212: 2381-6.

  73. Schetter AJ, Heegaard NH y Harris CC. Inflammation and cancer: interweaving microRNA, free radical, cytokines and p53 pathways. Carcinogen 2010; 31: 37-49.

  74. Weinberg F, Chandel NS. Reactive oxygen species-dependentsignaling regulates cancer. Cell Mol Life Sci 2009. 66: 3663-73.

  75. Kandel ES, Skeen J, Majewski N, Di Cristofano A, Pandolfi PP, Feliciano CF, Gartel A, Hay N. Activation of Akt/protein cinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 2002; 7831-41.

  76. Los M, Maddika S, Erb B, Schulze-Osthoff K. Swtiching Akt: from survival signaling to deadly response. Bioessays 2009;31:492-5.

  77. Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I, Untermann T, Hay N. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitize cells to oxidative apoptosis. Cancer Cell 2008; 14: 458-70.




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