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Organo Oficial de la Sociedad Mexicana de Urología

2008, Number 4

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Rev Mex Urol 2008; 68 (4)

Clinical/pathological characteristics associated with size and metastasis in renal cell tumors

Cantellano-Orozco M, Vázquez-Ortega L, Camarena-Reynoso H, Shuck-Bello C, Leos-Acosta C, Mata-Miranda MP, Morales-Montor G, Pacheco-Gahbler C, Calderón-Ferro F

Language: Spanish
References: 27
Page: 207-214
PDF size: 152.78 Kb.


ABSTRACT

Objective: To determine the association between clinical and pathological characteristics, metastasis incidence, recurrence incidence and survival curves in a kidney tumor patient population at the Hospital General Dr.Manuel Gea González.
Materials and Methods: Variables from a total of 70 patients presenting with kidney cancer were studied and their survival curves were determined. Multivariate Cox analysis was carried out over a maximum 80-month follow-up period.
Results: Of the 70 patients (n=70), 43 were men and 27 were women. Mean age was 58 years. Nuclear grade was F2:30 (42.8%), F3:23(32.8%), F4: 10 (14.2%) and F1:7 (10%). There was macroscopic hematuria in 40 patients (57.1%), lumbar pain in 24 (34.2%), palpable mass in 3 (4.2%) and 3 (4.2%) incidental cases. Four patients (5.7%) presented with the “classic triad”. There were 38 left kidney cases with a 5-year survival of 66% and 32 right kidney cases with a 5-year survival of 43%. Clear cell carcinoma was the predominant histological subtype, followed by papillary, sarcomatoid and chromophobe carcinomas.
Conclusions: Factors related to an unfavorable prognosis were female sex, left kidney lesions, Fuhrman III and sarcomatoid variant larger than 8cm progressing to metastasis or presenting with it at the onset.


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