León MG, Baquera HJ, Ortiz HC

Language: Spanish
References: 36
Page: 151-156
PDF size: 678.85 Kb.

ABSTRACT

A 64 year-old man presented with generalized lymphadenopathy. An excisional biopsy of a right inguinal lymph node showed a diffuse large B-cell lymphoma. Admixed with the large lymphoma cells were numerous Mott cells with large hyperchromatic nuclei and abundant eosinophilic cytoplasm and densely packed with numerous well-demarcated round small eosinophilic globules that completely obscured the cytoplasm and covered parts of the nucleus. The proportion of these two cell populations varied throughout the section. The cytoplasmic globules in the Mott cells stained bright red with Masson trichrome, black/blue with phosphotungstic acid hematoxylin, blue/violet with Gram, light red with Russell-Movat pentachrome and were weakly positive for periodic acid-Schiff (PAS). The large lymphoid cells were strongly immunopositive for CD20, CD79a, and Pax-5 and negative for CD3 and CD5. Mott cells were negative for Pax-5 but revealed diffuse strong nuclear staining for MUM1, membranous staining for CD138, staining in a rim attern for IgG and kappa light chain restriction. Most of the Mott cells showed membranous staining for CD20 and CD79a. The percentage of Ki-67 positive cells was 40%. Epstein-Barr virus encoded RNA (EBER) in situ hybridization was negative. A diagnosis of DLCBL with Mott cell differentiation was rendered. A brief history of Sir Frederick Walker Mott is presented.

REFERENCES

1. Christy C. The cerebrospinal fluid in sleeping sickness (trypanosomiasis). Liverpool School Trop Med Mem 1904;57:3-10.

2. Mott FW. Observations on the brains of men and animals infected with various forms of trypanosomes. Preliminary note. Proc R Soc Lond 1905;76:235-242.

3. Kodama A, Sakai H, Kobayashi K, Mori T, et al. B-cell intestinal lymphoma with Mott cell differentiation in a 1-year old miniature Dachshund. Vet Clin Pathol 2008;37:409-415.

4. Stacy NI, Nabity MB, Hackendahl N, Buote M, et al. B-cell lymphoma with Mott cell differentiation in two young adult dogs. Vet Clin Pathol 2009;38:113-120.

5. De Zan G, Zappulli V, Cavicchioli L, Di Martino L, et al. Gastric B-cell lymphoma with Mott cell differentiation in a dog. J Vet Diagn Invest 2009;21:715-719.

6. Tanimoto A, Hamada T, Yamamoto T, Kimura S, et al. MALT lymphoma with extreme plasma cell differentiation of the rectum. Am J Gastroenterol 2002; 97:1860-1862

7. Gupta A, Gumber S, Schnellbacher R, Bauer RW, Gaunt SD. Malignant B-cell lymphoma with Mott cell differentiation in a ferret (Mustela Putorius Furo). J Vet Diagn Invest 2010;22:469-473.

8. Fujiyoshi Y, Inagaki H, Teyeyama H, Murase T, Eimoto T. Mott cell tumor of the stomach with Helicobacter pylori infection. Pathol Intl 2001;51:43-46.

9. Kokosazde NV, Kovrigin AM, Probatova NA. Stomach MALTlymphoma with marked plasmacytic differentiation: a variant of Mott cell tumor. Arkh Patol 2004;66:44-42.

10. Posnett DN, Mouradian J, Mangraviti DJ, Wolf DJ. Mott cells in patients with lymphorpoliferative disorder. Differentiation of a clone of B lymphocytes into Mott cells. Am J Med 1984;77:125-130.

11. Rampisela D, Donner LR. An unusual self-limited clonal Mott cell proliferation with lymphoplasmacytic lymphoma-like features in a child with Wisckott-Aldrich syndrome and Von Recklinhausen’s neurofibromatosis. Pathol Res Practice 2010;206:467-471.

12. Brink T, Wagner B, Gebbers JO. Monoclonal plasma and Mott cells in a rectal adenoma. Histopathology 1999;34:81-82.

13. Shinozaki A, Ushiku T, Fukayam M. Prominent Mott cell proliferation in Epstein-Barr virus-associated gastric carcinoma. Hum Pathol 2010;412:134-138.

14. Wright PAL, Burns RB, Rothwell B, Mackenzie GM. The Harderian gland of the domestic fowl. J Anat 1971;110:307-315.

15. Jäck H M, Beck-Engeser GB, Sloan B, Wong ML, Wabl MA. A different sort of Mott cell. Proc Natl Acad Sci USA 1992;89:11688-11691.

16. Yang Y, Bekaris LG, Volg DT, Bagg A. Crystal-storing histiocytosis in plasma cell myeloma. Am J Hematol 2010;85:444-445.

17. Russell W. An address on a characteristic organism of cancer. BMJ 1890;2:1358-1360.

18. Russell W. The parasite of cancer. Lancet 1899;1:1138-1141.

19. Valetti C, Grossi CE, Milstein C, Sitia R. Russell bodies: A general response to secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum. J Cell Biol 1991;115:983-994.

20. Kopito RR, Siti R. Aggresomas and Russell bodies. Symptoms of cellular indigestion? EMBO reports 2000;31:225-231.

21. Zlotnick A. The “morular cell” and the “grape cell” in bone marrow and peripheral blood. Blood 1956;11:1140-1147.

22. Fukumoto J, Greenberg PL. Mott cells, ASH Image Bank. Am Soc Hematol 2006;926:6-00029.

23. Goldman A, Gebrail F, Cualing H. Pathologic quiz case; a 56 year-old woman with a recurring neck mass Arch Pathol Lab Med 2003;127:e285-e287.

24. Obituary. Sir Frederic Mott, KBE, MD, FRCP, FRS, LLD. Br Med J 1926;19;1063-1066.

25. Mott FW. The differential diagnosis of syphilis and parasyphilis of the nervous system: Introduction to a discussion on syphilis and parasyphilis of the nervous system at the Medical Society of London on November 13th, 1911. Br Med J 1911;18;1337- 1342.

26. Mott FW. Studies in the pathology of dementia praecox Proc R Soc Med 1920;13(Sect Psych):25-63.

27. Mott FW. The Croonian Lectures on Degeneration of the Neuron: Delivered at the Royal College of Physicians of London. Br Med J 1900;2:82-90.

28. Mott FW. The changes in the central nervous system in hypothyroidism. Proc R Soc Med 1917;10(Pathol Sect):51-59.

29. Mott FW. The Croonian Lectures on degeneration of the neuron: Delivered at The Royal College of Physicians Of London. Br Med J 1900;30;1582-1590.

30. Mott FW. The Croonian Lectures on Degeneration of the Neuron: Delivered at the Royal College of Physicians of London. Br Med J 1900;23:1517-1524.

31. Mott FW. The Comparative Neuropathology of Trypanosome and Spirochaete Infections, with a Résumé of our Knowledge of Human Trypanosomiasis. Proc R Soc Med 1911;4(Pathol Sect):1-40.

32. Mott FW. The psychic mechanism of the voice in relation to the emotions. Br Med J 1915;11:845-847.