2008, Number 41
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Med Univer 2008; 10 (41)
Is it true that bone marrow autografting improves the prognosis of patients with multiple myeloma?: A single institution experience in Mexico
López OA, Ruiz DGJ, Ruiz AGJ
Language: Spanish
References: 8
Page: 187-189
PDF size: 244.30 Kb.
ABSTRACT
In a 14-year period in a single institution we have performed 30 stem cell autografts in patients with multiple myeloma. The median overall survival (OS) has not been reached, being above 7 years. Whereas the 84-month overall OS was found to be 77%. These data are clearly superior to those obtained in a group of 23 patients treated with melphalan / prednisone in the same institution who had a median SV of 33 months with a 72-month OS of 30%. It is concluded that, in our experience, the long-term survival of individuals with multiple myeloma who received an autograft is clearly superior to that of patients treated with conventional chemotherapy. The long-term prognosis of patients with MM has improved substantially in the Clínica RUIZ de Puebla since the introduction of high-dose therapy rescued with autologous stem cell support.
REFERENCES
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Ruiz-Argüelles GJ, Gómez-Rangel D, Ruiz-Delgado GJ, Aguilar-Romero L. Multiple myeloma in México: a single institution, twenty-year experience. Arch Med Res 2004;35:163-7.
Kyle RA. Long-term survival in multiple myeloma. N Engl J Med 1983;308:314-6.
Kumar S, Gertz MA, Dispenzieri A, Lacy MQ, et al. Response rate, durability of response and survival after thalidomide therapy for relapsed multiple myeloma. Mayo Clin Proc 2003;78:34-9.
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Vela OJ, García REMA, Padilla GY, Gómez AD, et al. Autologous peripheral blood stem cell transplantation in multiple myeloma using oral versus IV melphalan. Ann Hematol 2007;86:277-82.
Ruiz AGJ, Gómez RD, Ruiz DGJ, Ruiz AA, et al. Results of an autologous non-cryopreserved, unmanipulated peripheral blood hematopoietic stem cell transplant program: a single institution, 10-year experience. Acta Haematol 2003;110:179-83.
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