Zárate A, Hernández-Valencia M, Austria E, Saucedo R, Hernández M

Language: Spanish
References: 14
Page: 303-307
PDF size: 307.15 Kb.

ABSTRACT

The production of anti-müllerian hormone for the ovarian follicles begins near the puberty and the circulating levels begin to descend progressively in the stage of the pre-menopause coinciding with the depletion follicular and in consequence the menstrual cycles become irregular, frequently anovulatories. Therefore, concentration of anti-müllerian hormone shows a close correlation with follicular reserve and reproductive capacity, more than FSH and estradiol measurements. We described two patients that developed premature ovarian failure without previous diagnosis and therefore just were treated pharmacologically with estrogen-progestagen to induce menstrual bleeding. In blood of both patients was found low levels (≤ 4 ng/mL) of anti-müllerian hormone, and by means of sonography the absence of follicles was demonstrated in the ovaries. Has intended that premature ovarian failure could be of a chromosomal dysfunction, similar to other gonadal dysgenesias, another explanation of the mechanism is that it could be for development of some autoimmunity dysfunction. Therefore, the combined hormonal substitution of estrogen with progestagen should stay during several years to avoid the complications for the lack of estrogens; in some cases, could be informed on offering the pregnancy possibility by means of the attended fertilization using ovules donor.

REFERENCES

1. Burger HG, Hale GE, Dennerstein L, Robertson DM. Cycle hormone changes during perimenopause: the key role of ovarian function. Menopause 2008;15:603-610.

2. Soules MR, Sherman S, Parrot E, Rebar R, et al. Executive summary: stages of reproductive aging workshop (STRAW). Fertil Steril 2001;76:874-878.

3. Santoro N. Mechanisms of premature ovarian failure. Ann Endocrinol (Paris) 2003;64:87-92.

4. Jost A, Vigier B, Prepin J, Perchellet JP. Studies on sex differentiation in mammals. Recent Prog Hormone Res 1973,29:1-25.

5. Maneiro PJ, Alarcón D, Canales ES, Fishbeing M, et al. Menopausia precoz como expresión de una enfermedad de tipo autoinmune. Estudio endocrino e inmunológico. Ginec Obstet Mex 1973;33:407-413.

6. Zarate A, Karchmer S, Gomez E, Castelazo L. Premature menopause. Am J Obstet Gynec 1970;106:110-114.

7. Arias AR. Deficiencia ovárica prematura. Rev Med Chile 1950;78:373-376.

8. Jost A. Problems of fetal endocrinology. The gonadal and hypophyseal hormones. Prog Hormone Res 1953;8:379-385.

9. Molina RA, Greenblatt RB, Byrd JR. Premature menopause a “form frusta” of gonadal dysgenesis. Am J Obstet Gynec 1968;100:1148-1150.

10. De Vos M, Devroey P, Fauser B. Primary ovarían insufficiency. Lancet 2010;376:911-921.

11. Federman DD. The biology of human sex differences. N Eng J Med 2006;354:1507-1514.

12. Vazquez AM, Kenny FM. Ovarian failure and antiovarian antibodies in association with hyporathyroidism, moniliasis and Addison and Hashimoto diseases. Obstet Gynec 1964;89:83-91.

13. Hoek A, Schoemaker J, Drexhage HA. Premature ovarían failure and ovarían autoimminity. Endocr Rev 1997;18:107-134.

14. Ayala A, Canales ES, Karchmer S, Alarcón D, Zarate A. Premature ovarian failure and hypothyroidism associated with Sicca syndrome. Obstet Gynec 1979;53:98-101.