2010, Number 1
<< Back
Rev Mex Cir Pediatr 2010; 17 (1)
Posttraumatic cyst successfully treated with a dose of OK 432 First case in Mexico
Sánchez-Michaca VJ, Jiménez-Urueta PS, Sánchez-Nava J, Mejía-Sánchez MR, Castañeda-Ortiz RA
Language: Spanish
References: 16
Page: 44-48
PDF size: 295.99 Kb.
ABSTRACT
Introduction: OK-432 a penicillin-killed and lyophilized preparation of a low virulence of Streptococcus pyogenes (gorup A) , has been successfully used as an inmunotherapeutic agent in many types de malignancies , incluiding head an nech cancer and lymphangiomas We have also reported that OK-432in patiente with postraumatic cystis of rigth leg.
Case report: A 11 year old had a leg postraumatic cystic of 15 cm x 30 cm , We have also reported that OK-432 in patiente with postraukmatic cystis de leg left temporary fever inmediatiately follewed the injection, but 60 days later the cystic disapeared without a trace
Discussion: An intralesional injection of 0k-432 shrunk the postraumatic cystic was efficacious .Therefore, we consider that this therapy is still at the expirimental stage of postraumatic cystis and the further evaluation of its efficacy , complications, and dosimetry will be needed in many other before its widespread use .
REFERENCES
Nigel H, MRCS, Niyi ade A, Derek J, Roebuck, Edgar M. Is intralesional injection of OK-432 effective in the treatment of lymphangioma in children? Surgery 2003;133(3): 238-242
Susuki N. Tsuchida Y. Takahasi A. Kuroiwa M, Mikeda H, Mohara J. Et al. Prenatally diagnosed cystic lymphangioma in infants. J Pediatr Sur 1998;33:1599-604
EmeryP, Bailey CM, Evans JN. Cystic hygroma of the head and neck: a review of 37 cases. J L Laryngol Otol 1984,98:613-9
Gosta C, Richard K. OK-432 therapy for lymphatic malformation inj 32 patients ( 28 children). Int J Pediatric Oto Rhino Laryng 2002;65:1-6
Smith, Richard JH, Burke MD, Diane K, Sato RN, Yutaka MD, Roliland I et al. OK-432 Therapy for lymphangiomas. Arch Otolaryngeal Head Neck Surg 1996;122(11): 1195-1199
Yasuhito S, Akira O, Yuko G, Tokuhiko M, Hisasa O, Yuichi I. Manegement of orbital lymphangioma using intralesional injection of OK-432. Br J Ophthalmol 2000;84:614-617
7.- Luzzato c, Midrio P, Tchaprassian Z, Guglielmi M. Esclesrosing tretamente of lynphangiomas with OK 432. Arch Dis Child 2000 82(4):316-318
Kobayhasi D. Kumagai H, Satsuma S. Cavernous lymphangioma of leg in children tretd by injection of OK-432 after. J Bone and J Surg 2003;85(6):891-94
Chantal M. Gighuere MD, Nancy M, Bauman, D Yutaka S, Diane K, Burkewith 0K-432 (Picibinil) sclerotherapy. Arch Dis Child 2000 82(4):316-318
Xiao LI, Zheng Fan, Tsugiya M, Charles R. Enhacement of natural Killer Cell Activity in human inmunodeficiency virus-infected subjects by in vitro treatmentre with biologic response modifiere OK-432. Am Soc Microb 1995 ;2(1):91-97.
Masato O, Tetsuya O. Tomoyuki T, Go O, Sachiko F, Hidemtoo N, Sharif UA, et al. Involvement of toll-like receptor 4 signaling in interferon-producction and antitumor effect by Streptococcal agent OK-432. J Nat Can Inst 2003;95(4):316-32.
Jiménez UP, Terriquez RS, Gallego GJ, Mejia, MS, Sanchez NJ. Tratamiento de linfangioma quistico. Congreso internacional Cirugía Pediátrica Acapulco Gro. Rev Mex Cir Ped 2002 ; 114
Sanchez NJ; Jiménez UP, Mejia MS,Reyes RT. Bracho BE. OK432 Terapia para linfagioma quistico en niños. ¿En cuanto tiempo colapsan? Estudio muticentrico. Congreso Internacional Cirugía Pediátrica Acapulco Gro. Rev Mex Cir Ped 2002; 162.
Fasching G, Sinzig M. OK-432 as a sclerosing agent to treat wound-healing impairment. Eur J Pediatr Surg. 2007;17(6):431-2.
Knipping S, Goetze G, Neumann K, Bloching M. Sclerotherapy of cervical cysts with Picibanil (OK-432). Eur Arch Otorhinolaryngol. 2007 Apr;264(4):423-7. Epub 2006 Nov 3.
Chen M, Chen CP, Shih JC, Chou HC, Yu CL, Wang BT, Hsieh CY. Antenatal treatment of chylothorax and cystic hygroma with OK-432 in nonimmune hydrops fetalis. Fetal Diagn Ther. 2005 Jul-Aug;20(4):309-15