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Órgano Oficial del Instituto de Ciencias de la Salud, Hospital Escuela y Facultad de Medicina-Xalapa

2009, Number 2

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Rev Med UV 2009; 9 (2)

Long-term qualitative evaluation of the activation state of microglial cells in the brain of neonatally enucleated mice

Escalante-Martínez D, Chavarría A, Gutiérrez-Ospina G, Romo-González T

Language: Spanish
References: 50
Page: 13-18
PDF size: 657.65 Kb.


ABSTRACT

Introduction. Cellular elements and secretory products of the immunological system promote and/or facilitate neuralreorganization. Although a large-scale reorganization takes place in the brain of neonatally blinded rodents, it is yet unclear whether immunological factors modulate such response. OBJETIVES, MATERIAL and METHODS. The present work evaluated the state of activation of microglial cells and their distribution of pro- and anti-inflammatory cytokines in the brain of adult control rats and of those blinded at birth by means of immuno-peroxidase techniques. Results: (i) Corticaland hippocampal microglia displayed, qualitatively, a reduced number of cellular processes immunoreactive for F4/80 in blinded rats. (ii) Microglial cells and perivascular macrophages were positive for MHCII at various locations of blinded rats’ brains. Conclusions. The data presented support that microglial cells maintain a long-term pseudo-actived state in some areas of the brain of blinded rats, such condition could facilitates and/or promotes constant reorganization events in these areas.


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