medigraphic.com
ISSN 2500-7106 (Electronic)
ISSN 0123-2576 (Print)
Medicina & Laboratorio

2009, Number 09-10

<< Back Next >>

Medicina & Laboratorio 2009; 15 (09-10)

Helicobacter pylori and platelets. Preliminary study.

Castaño ITL, Rojas ACA, Calvo BVD, Escobar GGE, Valencia ZLM

Language: Spanish
References: 83
Page: 457-455
PDF size: 431.66 Kb.


ABSTRACT

Introduction: According to the scientific literature, Helicobacter pylori (H. pylori) infection is a growing problem for the Health System in developing countries, including Colombia, with severe digestive and extradigestive manifestations such as hematologic disorders, mainly associated with platelets, that can increase the cardiovascular risk, particularly the platelet count and the percentage of immature platelets. Objective: To determine the association between H. pylori infection and platelet changes in a healthy population. Methods: Cross-sectional observational study in 511 individuals who attended the Laboratorio Clínico Hematológico in Medellín, during 2008. H. pylori infection was determined by the 13C-urea breath test, and platelet changes were determined with the type VI hemogram analysis. Results: A total of 197 (38,6%) patients had a positive H. pylori breath test, 37,5% of them were women. H. pylori infection was found in 46,5% of the patients who had abnormal values in their platelet count and immature platelet percentage. Conclusions: in the general healthy population, no association was found between H. pylori infection and platelet changes. The cross-sectional design of the present study limited the causative analysis; a study with a longer follow-up period.


REFERENCES

  1. Weaver LT. Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 16 February 1995. Aspects of Helicobacter pylori infection in the developing and developed world. Helicobacter pylori infection, nutrition and growth of West African infants. Trans R Soc Trop Med Hyg 1995; 89: 347-350.

  2. Duque JJ. Helicobacter pylori en la mucosa gástrica de cadáveres de niños. Iatreia 1999; 12: 135-138.

  3. Campuzano-Maya G, Hoyos-Castano D, Calvo- Betancur VD, Suarez-Ramirez OA, Lizcano- Cardona D, Rojas-Arbelaez CA. Prevalencia de la infeccion por Helicobacter pylori en medicos de Medellin, Colombia. Acta Gastroenterol Latinoam 2007; 37: 99-103.

  4. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175-1186.

  5. Campuzano-Maya G. Proof of an association between Helicobacter pylori and idiopathic thrombocytopenic purpura in Latin America. Helicobacter 2007; 12: 265-273.

  6. Barabino A. Helicobacter pylori-related iron deficiency anemia: a review. Helicobacter 2002; 7: 71-75.

  7. Desai HG, Gupte PA. Helicobacter pylori link to pernicious anaemia. J Assoc Physicians India 2007; 55: 857-859.

  8. Frigo P, Lang C, Reisenberger K, Kolbl H, Hirschl AM. Hyperemesis gravidarum associated with Helicobacter pylori seropositivity. Obstet Gynecol 1998; 91: 615-617.

  9. Buyukgebiz A, Dundar B, Bober E, Buyukgebiz B. Helicobacter pylori infection in children with constitutional delay of growth and puberty. J Pediatr Endocrinol Metab 2001; 14: 549-551.

  10. Bravo LE, Mera R, Reina JC, Pradilla A, Alzate A, Fontham E, et al. Impact of Helicobacter pylori infection on growth of children: a prospective cohort study. J Pediatr Gastroenterol Nutr 2003; 37: 614-619.

  11. Hernando-Harder AC, Booken N, Goerdt S, Singer MV, Harder H. Helicobacter pylori infection and dermatologic diseases. Eur J Dermatol 2009.

  12. Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, et al. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J 1994; 71: 437-439.

  13. Migneco A, Ojetti V, Specchia L, Franceschi F, Candelli M, Mettimano M, et al. Eradication of Helicobacter pylori infection improves blood pressure values in patients affected by hypertension. Helicobacter 2003; 8: 585-589.

  14. Sung JJ, Sanderson JE. Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease. Heart 1996; 76: 305-307.

  15. Majka J, Rog T, Konturek PC, Konturek SJ, Bielanski W, Kowalsky M, et al. Influence of chronic Helicobacter pylori infection on ischemic cerebral stroke risk factors. Med Sci Monit 2002; 8:CR675-684.

  16. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De Luca A, et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. Cephalalgia 2000; 20: 561-565.

  17. Takashima T, Adachi K, Kawamura A, Yuki M, Fujishiro H, Rumi MA, et al. Cardiovascular risk factors in subjects with Helicobacter pylori infection. Helicobacter 2002; 7: 86-90.

  18. Scharnagl H, Kist M, Grawitz AB, Koenig W, Wieland H, Marz W. Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol. Am J Cardiol 2004; 93: 219-220.

  19. Karpouza A, Samouilidou E, Karagiannis S, Kostopoulou V, Sotiropoulou M, Roma E, et al. Patients with duodenal ulcer have lower levels of serum cholesterol compared to other dyspeptic patients independently of Helicobacter pylori status. Scand J Gastroenterol 2008; 43: 922-928.

  20. American Heart Association. Heart and Stroke facts: 1996 statistical supplement. Dallas: American Heart Association; 1996: 1-23.

  21. Van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994; 89: 36-44.

  22. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999; 340: 115-126.

  23. Elton PJ, Ryman A, Hammer M, Page F. Randomised controlled trial in northern England of the effect of a person knowing their own serum cholesterol concentration. J Epidemiol Community Health 1994; 48: 22-25.

  24. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333: 1301-1307.

  25. Pfeffer MA, Sacks FM, Moye LA, Brown L, Rouleau JL, Hartley LH, et al. Cholesterol and Recurrent Events: a secondary prevention trial for normolipidemic patients. CARE Investigators. Am J Cardiol 1995; 76: 98C-106C.

  26. Pasternak RC, Grundy SM, Levy D, Thompson PD. 27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 3. Spectrum of risk factors for coronary heart disease. J Am Coll Cardiol 1996; 27: 978-990.

  27. Lewis JC, Kottke BA. Endothelial damage and thrombocyte adhesion in pigeon atherosclerosis. Science 1977; 196: 1007-1009.

  28. Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation 1991; 84: 613-617.

  29. Haerem JW. Platelet aggregates in intramyocardial vessels of patients dying suddenly and unexpectedly of coronary artery disease. Atherosclerosis 1972; 15: 199-213.

  30. van der Bom JG, Heckbert SR, Lumley T, Holmes CE, Cushman M, Folsom AR, et al. Platelet count and the risk for thrombosis and death in the elderly. J Thromb Haemost 2009; 7: 399-405.

  31. Elwood PC. Platelets, aspirin and cardiovascular disease. J R Coll Physicians Lond 1976; 10: 347- 350.

  32. U.S. Preventive Services Task Force. Aspirin prophylaxis for cardiovascular disease. Am Fam Physician 1989; 40: 117-120.

  33. Lievre M, Cucherat M. Aspirin in the secondary prevention of cardiovascular disease: an update of the APTC meta-analysis. Fundam Clin Pharmacol 2009.

  34. Briggs C, Harrison P, Machin SJ. Continuing developments with the automated platelet count. Int J Lab Hematol 2007; 29: 77-91.

  35. Campuzano-Maya G. Del hemograma manual al hemograma de cuarta generación. Medicina & Laboratorio 2007; 13: 511-550.

  36. Sociedad Colombiana de Patología Clínica. Manual de Codificación, Nomenclatura, Nivelación y Valores de Exámenes de laboratorio Clínico. Medellín, Colombia: Edimeco S.A.; 2009.

  37. Siebers R, Maling T. Mean platelet volume in human essential hypertension. J Hum Hypertens 1995; 9: 207.

  38. Coban E, Adanir H, Bilgin D. The association of mean platelet volume levels with hypertensive retinopathy. Platelets 2008; 19: 115-118.

  39. Duygu H, Turkoglu C, Kirilmaz B, Turk U. Effect of mean platelet volume on postintervention coronary blood flow in patients with chronic stable angina pectoris. J Invasive Cardiol 2008; 20: 120-124.

  40. Yilmaz MB, Cihan G, Guray Y, Guray U, Kisacik HL, Sasmaz H, et al. Role of mean plateletvolume in triagging acute coronary syndromes. J Thromb Thrombolysis 2008; 26: 49-54.

  41. High mean platelet volume after myocardial infarction. Br Med J (Clin Res Ed) 1985; 290: 238-239.

  42. Kilicli-Camur N, Demirtunc R, Konuralp C, Eskiser A, Basaran Y. Could mean platelet volume be a predictive marker for acute myocardial infarction? Med Sci Monit 2005; 11: CR387-392.

  43. Muscari A, Puddu GM, Cenni A, Silvestri MG, Giuzio R, Rosati M, et al. Mean platelet volume (MPV) increase during acute non-lacunar ischemic strokes. Thromb Res 2009; 123: 587-591.

  44. Tavil Y, Sen N, Yazici HU, Hizal F, Abaci A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res 2007; 120: 245-250.

  45. Lippi G, Salvagno GL, Targher G, Guidi GC. Relationship between mean platelet volume and biochemical components of the metabolic syndrome. Clin Drug Investig 2007; 27: 731-732; author reply 732-733.

  46. Lakkis N, Dokainish H, Abuzahra M, Tsyboulev V, Jorgensen J, De Leon AP, et al. Reticulated platelets in acute coronary syndrome: a marker of platelet activity. J Am Coll Cardiol 2004; 44: 2091- 2093.

  47. Lerkevang Grove E, Hvas AM, Dalby Kristensen S. Immature platelets in patients with acute coronary syndromes. Thromb Haemost 2009; 101: 151-156.

  48. McCabe DJ, Harrison P, Sidhu PS, Brown MM, Machin SJ. Circulating reticulated platelets in the early and late phases after ischaemic stroke and transient ischaemic attack. Br J Haematol 2004; 126: 861-869.

  49. Monteagudo M, Amengual MJ, Munoz L, Soler JA, Roig I, Tolosa C. Reticulated platelets as a screening test to identify thrombocytopenia aetiology. QJM 2008; 101: 549-555.

  50. Sakakura M, Wada H, Abe Y, Nishioka J, Tomatsu H, Hamaguchi Y, et al. Usefulness of measurement of reticulated platelets for diagnosis of idiopathic thrombocytopenic purpura. Clin Appl Thromb Hemost 2005; 11: 253-261.

  51. D’Erasmo E, Aliberti G, Celi FS, Romagnoli E, Vecci E, Mazzuoli GF. Platelet count, mean platelet volume and their relation to prognosis in cerebral infarction. J Intern Med 1990; 227: 11-14.

  52. Gursoy A, Ertugrul DT, Pamuk B, Sahin M, Asik M, Yilmaz H, et al. Mean platelet volume in patients with polycystic ovary disease. Platelets 2006; 17: 505-506.

  53. Yavasoglu I, Kucuk M, Cildag B, Arslan E, Gok M, Kafkas S. A novel association between polycystic ovary syndrome and Helicobacter pylori. Am J Med Sci 2009.

  54. Campuzano-Maya G. An optimized 13C-urea breath test for the diagnosis of H pylori infection. World J Gastroenterol 2007; 13: 5454-5464.

  55. Logan RP, Dill S, Bauer FE, Walker MM, Hirschl AM, Gummett PA, et al. The European 13C-urea breath test for the detection of Helicobacter pylori. Eur J Gastroenterol Hepatol 1991; 3: 915-921.

  56. Campuzano-Maya G. Prueba de aliento con 13C-urea en el diagnóstico de Helicobacter pylori. Anales de la Academia de Medicina de Medellín 1999; 12: 25-37.

  57. República de Colombia, Ministerio de Salud. Resolución No. 008430 de 1993 (4 de octubre de 1993), por la cual se establecen las normas científicas, técnicas y administrativas para la investigación en salud. http://www.minproteccionsocial. gov.co/VBeContent/library/documents/DocNews- No267711.pdf.

  58. República de Colombia, Ministerio de Salud. Resolución No. 1995 de 1999 (8 de julio de 1999), por la cual se establecen normas para el manejo de la Historia Clínica. http://www.comvezcol.org/ archivos/pdf/resolucion_1995_1999.pdf

  59. The report of the Digestive Health Initiative. International Update Conference on Helicobacter pylori. Gastroenterology 1997; 113: S4-8.

  60. Fennerty MB. Helicobacter pylori: why it still matters in 2005. Cleve Clin J Med 2005; 72 Suppl 2: S1-7; discussion S14-21.

  61. Saad R, Chey WD. A clinician’s guide to managing Helicobacter pylori infection. Cleve Clin J Med 2005; 72: 109-110, 112-103, 117-108 passim.

  62. Axon A. Helicobacter pylori: what do we still need to know? J Clin Gastroenterol 2006; 40: 15-19.

  63. Sanchez Ceballos F, Taxonera Samso C, Garcia Alonso C, Alba Lopez C, Sainz de Los Terreros Soler L, Diaz-Rubio M. Prevalencia de la infeccion por Helicobacter pylori en poblacion sana en la Comunidad de Madrid. Rev Esp Enferm Dig 2007; 99: 497-501.

  64. Campuzano-Maya G. Prueba de aliento con 13C-urea en el diagnóstico de Helicobacter pylori. Anales de la Academia de Medicina de Medellín 1999; 12: 25-37.

  65. Elizalde JI, Gomez J, Panes J, Lozano M, Casadevall M, Ramirez J, et al. Platelet activation In mice and human Helicobacter pylori infection. J Clin Invest 1997; 100: 996-1005.

  66. Ando K, Shimamoto T, Tauchi T, Ito Y, Kuriyama Y, Gotoh A, et al. Can eradication therapy for Helicobacter pylori really improve the thrombocytopenia in idiopathic thrombocytopenic purpura? Our experience and a literature review. Int J Hematol 2003; 77: 239-244.

  67. Arnold DM, Bernotas A, Nazi I, Stasi R, Kuwana M, Liu Y, et al. Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review. Haematologica 2009; 94: 850-856.

  68. Emilia G, Longo G, Luppi M, Gandini G, Morselli M, Ferrara L, et al. Helicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura. Blood 2001; 97: 812-814.

  69. Emilia G, Luppi M, Torelli G. Helicobacter pylori and idiopathic thrombocytopenic purpura. Ann Intern Med 2004; 141: 820; author reply 820.

  70. Franchini M, Cruciani M, Mengoli C, Pizzolo G, Veneri D. Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis. J Antimicrob Chemother 2007; 60: 237-246.

  71. Garcia Perez A, Valverde de La Osa J, Gimenez Samper M, Alonso Garcia I. Resolucion de una purpura trombocitopenica autoinmune despues del tratamiento erradicador de Helicobacter Pylori. Sangre (Barc) 1999; 44: 387-388.

  72. Grimaz S, Damiani D, Brosolo P, Skert C, Geromin A, de Pretis G. Resolution of thrombocytopenia after treatment for Helicobacter pylori: a case report. Haematologica 1999; 84: 283-284.

  73. Jaing TH, Yang CP, Hung IJ, Chiu CH, Chang KW. Efficacy of Helicobacter pylori eradication on platelet recovery in children with chronic idiopathic thrombocytopenic purpura. Acta Paediatr 2003; 92: 1153-1157.

  74. Kurekci AE, Atay AA, Sarici SU, Ozcan O. Complete platelet recovery after treatment of Helicobacter pylori infection in a child with chronic immune thrombocytopenic purpura: a case report. Pediatr Hematol Oncol 2004; 21: 593-596.

  75. Rajantie J, Klemola T. Helicobacter pylori and idiopathic thrombocytopenic purpura in children. Blood 2003; 101: 1660.

  76. Sato R, Murakami K, Watanabe K, Okimoto T, Miyajima H, Ogata M, et al. Effect of Helicobacter pylori eradication on platelet recovery in patients with chronic idiopathic thrombocytopenic purpura. Arch Intern Med 2004; 164: 1904-1907.

  77. Soldinger E, Pilia MC, Piubello W, Nadali G. Multi-resistant idiopathic thrombocytopenia successfully treated by eradication of Helicobacter pylori. Dig Liver Dis 2001; 33: 732.

  78. Veneri D, Franchini M, Gottardi M, D’Adda M, Ambrosetti A, Krampera M, et al. Efficacy of Helicobacter pylori eradication in raising platelet count in adult patients with idiopathic thrombocytopenic purpura. Haematologica 2002; 87: 1177-1179.

  79. Cover TL, Glupczynski Y, Lage AP, Burette A, Tummuru MK, Perez-Perez GI, et al. Serologic detection of infection with cagA+ Helicobacter pylori strains. J Clin Microbiol 1995; 33: 1496- 1500.

  80. Sullivan PB, Thomas JE, Wight DG, Neale G, Eastham EJ, Corrah T, et al. Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition. Arch Dis Child 1990; 65: 189-191.

  81. Gómez NA, Salvador A, Vargas PE, Zapatier JA, Alvarez J. Seroprevalencia de Helicobacter pylori en la poblacion infantil ecuatoriana. Rev Gastroenterol Peru 2004; 24: 230-233.

  82. Cave DR. How is Helicobacter pylori transmitted? Gastroenterology 1997; 113: S9-14.

  83. Egan BJ, Katicic M, O’Connor HJ, O’Morain CA. Treatment of Helicobacter pylori. Helicobacter 2007; 12 Suppl 1: 31-37.




2020     |     www.medigraphic.com