Gómez-Macías GS, Garza-Guajardo R, Flores-Gutiérrez JP, Vidal-Gutiérrez Ó, Barboza-Quintana O

Language: Spanish
References: 15
Page: 571-576
PDF size: 483.70 Kb.

ABSTRACT

The gynandroblastoma is an extremely rare sexual cord stromal tumor, which contains both male and female elements, characterized by Sertoli or Leydig cells and granulose cells. We describe an ovarian gynandroblastoma in a 28 year-old female patient, found accidentally during a cesarean section operation. There is only one reported case in world literature occurring in a pregnant woman. The principal component we found was adult granulose cells, with a microfollicular pattern, and the presence of luteinized cells in some areas; besides we found the presence of well differentiated Sertoli cells elements, in addition to Leydig cells groups, in over 10% of the tumoral surface. Inmunohistochemical stainings were performed: citokeratin, which resulted positive in Sertoli cells and negative in granulose cells; and inhibin, which was positive in both components showing its mixed origin.

REFERENCES

1. Kalir T, Friedman F Jr. Gynandroblastoma in pregnancy: case report and review of literature. Mt Sinai J Med 1998;65:292-95.

2. Kapella M, Bakeland D, Blin V, Menzli A, Massri K. Gynandroblastoma: a rare ovarian tumour. Case report. Gynecol Obstet Fertil 2007;35(3):228-231.

3. Novak ER. Gynandroblastoma of the ovary: review of 8 cases from the ovarian tumor registry. Obstet Gynecol 1967;30(5):709-715.

4. Zhang SQ. Gynandroblastoma of the ovary. A case report. Chin Med J (Engl.) 1991;104(1):75-77.

5. Yamada Y, Ohmi K, Tsunematu R, Yokota H, et al. Gynandroblastoma of the ovary having a typical morphological appearance: a case study. Jpn J Clin Oncol 1991;21:62-68.

6. McCluggage WG, Sloan JM, Murnaghan M, White R. Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands. Histopathology 1996;29(3):253-257.

7. Roth LM. Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int J of Gynecol Pathol 2006;25:199-215.

8. Broshears JR, Roth LM. Gynandroblastoma with elements resembling juvenile granulose cell tumor. Int J Gynecol Pathol 1997;16(4):387-391.

9. Jaworski RC, Fryatt JJ, Turner TB, Osborn RA. Gynandroblastoma of the ovary. Pathology 1986;18(3):348-351.

10. Martin-Jimenez A, Condom-Munró E, Valls-Porcel M, Giné-Martin L, et al. [Gynandroblastoma of the ovary. Review of literture]. J Gynecol Obstet Biol Reprod (Paris) 1994;23(4):392-394.

11. Fukunaga M, Endo Y, Ushigome S. Gynandroblastoma of the ovary: a case report with inmunohistochemical and ultrastructural study. Virchows Arch 1997;430(1):77-82.

12. Sayar H, Lhomme C, Verschraegen CF. Malignant adnexal masses in pregnancy. Obstet Gynecol Clin North Am 2005;32:569-593.

13. Antunes L, Ounnoughene-Piet M, Hennequin V, Maury F, et al. Gynandroblastoma of the testis in an infant: a morphological, immunohistochemical and in-situ hybridization report. Histopathology 2002;40(4):395-397.

14. Scully RE. Tumors of the ovary and maldeveloped gonads. Atlas of Tumor Pathology, Sec Ser, Fasc 16. Washington DC: AFIP, 1979;p:208.

15. Chivukula M, Hunt J, Carter G, Kelley J, et al. Recurrent gynandroblastoma of ovary. A case report: a molecular and immunohistochemical analysis. Int J Gynecol Pathol 2007;26(1):30-33.