2000, Number 2
<< Back Next >>
Rev Mex Pediatr 2000; 67 (2)
Effectiveness of the ketotifeno vs immunotherapy in the bronchial chronicle asthma in children
José Antonio Carbajal Ugarte, Pastrana HE, Sevilla SA
Language: Spanish
References: 18
Page: 60-62
PDF size: 107.98 Kb.
ABSTRACT
The objective of the study is to evaluate the effectiveness of the ketotifeno vs immunotherapy, in the bronchial chronicle asthma, in the pediatric population.
It is a study of cases, in patient, with diagnosis of
bronchial asthma that has received treatment with ketotifeno or immunotherapy ≥ 6 months in continuous form.
Divides in two groups: Group A, treaties with ketotifeno and group B, treaties with immunotherapy.
The statistical analysis which consisted in the Student t test and the calculation of the standard deviation.
In the group A (n = 44), the time of evolution was presented in 3.3 ± 3.1 years, and treatment 0.7 ± 0.2 years, number of relapses 1.8 ± 1.6 and hospitalizations 1.1 ± 1.3 per year.
The group B (n = 33) time of evolution 3.9 ± 3.8 years, treatment 1.0 ± 0.7 years, relapses 1.9 ± 1.8 and hospitalizations 2.7 ± 7.1 per year.
The duration of the treatment and number of hospitalizations increase in the group that he received immunotherapy (p = ‹ 0.05), in relation to the relapses significant statistical difference was not presented.
In the group tried with immunotherapy, you associates antihistaminics and steroids in 96.9%, this translates little effectiveness of the therapy hyposensitize, conditioned by the long term evolution of the illness, possibly because these patients continue exposed to the allergens and irritants triggers.
REFERENCES
Rodríguez MR, Gazca BMR, Félix EF, Zamora LE. Incidencia y prevalencia del asma bronquial pediátrica. Rev Alergia Mex 1998; 45: 126-129.
Gasca AA, Ortega CM, Del Río NB, Sienra MJJ. Fisiopatología del asma. Rev Alergia Mex 1998; 45: 92-97.
Ter Laak AM, Kelder GM, Bast A, Timmerman H. Is theme a differncie in affinity of histamine H-1 receptor antagonist for CNS and periphenal receptores? an in vitro study. EVR J Pharmacol 1993; 232: 199-205.
Ruat M, Bouthenat ML, Schwants JC, Ganellin CR. Histamine H-1 receptor heart: unique electrophonetic morbility and autoradiographic localization. J Neurochem 1990; 55: 379-385.
Simons EF, Simons KJ. Antihistamines. In: Middleton E, Reedd ChR, Ellis EF, Adkinson NF, Yungingen JW, Busse WW. Allergy Principles and practice, 4th edition St Louis Missouri: Mosby 1993: 856-892.
Chowdhuny BA, Lanomer MA, Fraser CM. Cloning of a gene enconding the human H-1 histamine receptor. J Allergy Clin Immunol 1994; 93: 215-217.
Jansena MML. Astemizole; a nonsedatin antihistamine with fast and sustaines activity. Clin Rev Allergy 1992; 11: 35-63.
Carbajal UJA, Pastrana HE. Sinopsis terapéutica. A propóstio del ketotifeno en el tratamiento del asma bronquial. Rev Mex Pediatr 1998; 65(2): 74-75.
Ocaña H, Rubio M, Arrizabalaga R. Estudio abierto de la eficacia y tolerancia del ketotifeno en comprimidos de liberación prolongada en rinitis alérgica. An ORL Mex 1996; 41: 13-17.
Huerta LJ. Ketotifeno en las enfermedades alérgicas. Rev Alergia Mex 1991; 36: 151-157.
Cavazos GM, Lara BA, Treviño HM. Asma bronquial: evolución, IgE sérica y pruebas cutáneas. Rev Alergia Mex 1994; XLI(3): 77-79.
Espinosa MSM, Bolaños AJC, Miranda FAJ. Estudio de hipersensibilidad cutánea: intradérmica a extractos alergénicos y su relación con el lugar de residencia. Rev Alergia Mex 1992; XXXIX (6): 115-119.
Ramos MCJ, Canseco GC. Estudio de hipersensibibilidad a aeroalergénos frecuentes en la región centro de Coahuila. Rev Alergia Mex 1994; XLI(3): 84-87.
Ramírez FW, Olivé PA. Estandarización y caracterización de los extractos alergénicos. Rev Alergia Mex 1988; XXXV(4): 93-97.
Arroyave MC. Inmunoterapia con alta concentración de alergenos en pacientes pediátricos con asma o rinitis alérgica. Rev Alergia Mex 1994; XLI(5): 121-125.
Buenfil LJA. La inmunoterapia en el asma infantil. Rev Alergia Mex 1997; XLI(3): 67-73.
Rodríguez RM, Martín BA, Félix EF, Zamora LE, Durán CHJ, Gasca BM. Prevalencia del asma aguda en niños. Rev Alergia Mex 1998; 45: 9-12.
Pérez MJ. Utilidad de la inmunoterapia en el asma. Rev Alergia Mex 1998; 45: 117-118.