Guzmán BA, González BD

Language: Spanish
References: 16
Page: 105-109
PDF size: 160.39 Kb.

ABSTRACT

Human obesity is complex. It causes a multitude of long-term metabolic disorders, and finally an increment in cardiovascular morbidity, one of the first causes of mortality in industrialized nations. Leptin has arisen in the complex network of energy balance as one of the most important signals from adipose tissue to hypothalamus for decreasing energy uptake (feeding) and increasing energy consumption. However the role for hypocaloric diet in leptin levels has not been clarified, and it is less known in a cardiovascular high risk population as postmenopausal women. Hence, if a relationship among this conditions could be established, hyperleptinemia could be considerated as a prognostic indicator in cardiovascular risk. At this trial, we assessed whether there is any difference among leptin levels in postmenopausal women without hormone replacement therapy, who gathered diagnostic criteria for metabolic syndrome, once diet was installed. We determine body measures and periodic levels of serum leptin. Afterwards, the group underwent in a very low calorie diet for a 12-week period, assessing measures weekly. At the end of this period, we determined leptin levels again, to assess diet effect and weight reduction on them. Leptin levels presented normal-high values, possibly due to factors as hypostrogenism, GH deficiency or sarcopenia, although they correlated with weight loss and body mass indexes. We conclude that leptin levels cannot be considered as absolute prognostic factors in postmenopausal patients with metabolic syndrome.

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