medigraphic.com
ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2010, Number 3

<< Back Next >>

An Med Asoc Med Hosp ABC 2010; 55 (3)

Neuroendocrine lung tumors. Treatment strategies in small cell carcinoma with extensive disease

Padilla RÁL, Alban LF, Gerson R

Language: Spanish
References: 15
Page: 154-160
PDF size: 213.96 Kb.


ABSTRACT

Neuroendocrine tumors of the lung are a rare group of neoplasms with different origin, clinicopathological features and therapeutic strategies compared with non-endocrine lung tumors. They encompasses four entities with different biologic behavior: carcinoid tumor, atypical carcinoid tumor, small cell lung neuroendocrine carcinoma, and large cell neuroendocrine carcinoma. We present a case of a 52-year old woman with an advanced small cell lung neuroendocrine carcinoma. General features and histogenesis of neuroendocrine lung tumors are discussed, as well as therapeutic strategies in small cell neuroendocrine carcinoma of the lung.


REFERENCES

  1. Beasley MB, Brambilia E, Travis WD. The 2004 World Health Organization classification of lung tumors. Semin Roentgenol 2005; 40: 90-97.

  2. Ito T, Nogawa H, Udaka N et al. Development of pulmonary neuroendocrine cells of fetal hamster in explant culture. Lab Invest 1997; 77: 449-457.

  3. Gosney JR. Neuroendocrine cell populations in postnatal human lungs: Minimal variation from childhood to old age. Anat Rec 1993; 236: 177-180.

  4. Gosney JR, Sissons MC, Allibone RO. Neuroendocrine cell populations in normal human lungs: A quantitative study. Thorax 1988; 43: 878-882.

  5. Gustafsson BI, Kidd M, Chan A, Malfertheiner MV, Modlin IM. Bronchopulmonary neuroendocrine tumors. Cancer 2008; 113: 5-21.

  6. Adriaensen D, Brouns I, Pintelon I et al. Evidence for a role of neuroepithelial bodies as complex airway sensors: Comparison with smooth muscle-associated airway receptors. J Apll Physiol 2006; 101: 960-970.

  7. Van Lommel A. Pulmonary neuroendocrine cells (PNEC) and neuroepithelial bodies (NEB): Chemoreceptors and regulators of lung development. Paediatr Respir Rev 2001; 2: 171-176.

  8. Travis WD. The concept of pulmonary neuroendocrine tumours. In: Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC (eds): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon: IARC Press; 2004.

  9. Fink G, Krelbaum T, Yellin A et al. Pulmonary carcinoid: Presentation, diagnosis, and outcome in 142 cases in Israel and review of 640 cases from the literature. Chest 2001; 119: 1647-1651.

  10. Zacharias J, Nicholson AG, Ladas GP et al. Large cell neuroendocrine carcinoma and large cell carcinomas with neuroendocrine morphology of the lung: Prognosis alter complete resection and systematic nodal dissection. Ann Thorac Surg 203; 75: 348-352.

  11. Nicholson SA, Beasley MB, Brambilia E et al. Small cell lung carcinoma (SCLC): A clinicopathologic study of 100 cases with surgical specimens. Am J Surg Pathol 2002; 26: 1184-1197.

  12. Abidin AZ, Garassino MC et al. Targeted therapies in small cell lung cancer. Therapeutic Advances in Medical Oncology 2010; 2: 25-37.

  13. Small Cell Lung Cancer Treatment (PDQ). National Cancer Institute: www.cancer.gov 2009.

  14. Spira A, Ettinger D. Multidisciplinary Management of Lung Cancer. New Engl J Med 2004; 350: 379-392.

  15. Elias A, Baldini E. Last Literature Review 17.3 Small Cell Lung Cancer Treatment. UpToDate 2009.




2020     |     www.medigraphic.com