Vallejos MC, Enríquez GMA, López VMR, Valdez GJA, Pérez PKP

Language: Spanish
References: 15
Page: 131-134
PDF size: 97.62 Kb.

ABSTRACT

Helicobacter pylori is a gram(-) bacterium that colonizes the gastric mucosa; it plays a fundamental role in the development of digestive diseases such as chronic gastritis and peptic ulcer. Its worldwide prevalence is 20% in adult population and its frequency increases with age.
OBJECTIVE. Determine the prevalence of H. pylori infections in geriatric patients treated at a hospital in Puebla since January to December 2007.
MATERIAL AND METHODS. A cross-sectional study, retrospective, and descriptive review of records since January to December of 2007 of geriatric patients infected with H. pylori and treated at Hospital Regional de Puebla-ISSSTE.
RESULTS. Out of 74 patients treated at Geriatric Department in the specified time, we found 27 patients (36.48%) infected by H. pylori: 17 men (62.96%) and 10 women (37.04%). Predominant age range: 80 to 84 years-old (40.74%). Histological findings: 19 patients (70.37%), chronic gastritis; 5 (18.52%), duodenal ulcer; 2 (7.41%), gastric ulcer; and 1 (3.7%) gastric carcinoma. Predominant type of treatment: amoxicillin, omeprazole and clarithromycin (66.66%).
CONCLUSIONS. The prevalence of H. pylori increases considerably in the geriatric population. We recommend further research on these patients excluding important gastrointestinal pathology predisposing factors and evaluating gastroduodenal mucosa histopathological conditions to determine more accurately the etiological role of this microorganism.

REFERENCES

1. Cave DR, Go M, Cutler A, Goldstein J, Dunn B, Mobley H et al. “Transmission and epidemiology of Helicobacter pylori”. Am J Med 1996; 100(5A): 12-18.

2. Warren JR, Marshall B. “Unidentified curved bacilli on gastric epithelium in active chronic gastritis”. Lancet 1983; 1: 1273-1275.

3. Megraud F, Brassens-Rabbe MP, Denis F, Belbouri A, Hoa DQ. “Seroepidemiology of Campylobacter pylori infection in various populations”. J Clin Microbiol 1989; 27: 1870-1873.

4. Yoshiyama H, Nakazawa T. “Unique mechanism of Helicobacter pylori for colonizing the gastric mucus”. Microb Infect 2000; 2: 55-60.

5. Peek RM, Moss SF, Tham KT et al. “Helicobacter pylori, Cag A+ strains and dissociation of gastric epithelial cell proliferation from apoptosis”. J Natl Cancer Inst 1997; 89: 863-868.

6. Moss SF. “Helicobacter pylori induced apoptosis”. Gut 1998; 43: 592-594.

7. Shibata J et al. “Regulation of tumor necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection”. Gut 1999; 45(1): 24-31.

8. Tsuda M. “Essential role of Helicobacter pylori urease in gastric colonization: Definite proof using a ureasenegative mutant constructed by gene replacement”. Eur J Gastroenterol Hepatol 1994; 6: 49-52.

9. Rautelin H, Sipponen P, Seppala K, Sarna S, Danielsson D, Kosunen T. “Gastric inflammation and neutrophilactivating and cytotoxin-producing Helicobacter pylori strains”. Scand J Gastroenterol 1996; 92: 639-642.

10. Cover TL, Blaser MJ. “Helicobacter pylori infection. Advances internal medicine”. St Luois, Mosby 1996; VI: 85-177.

11. Cover Tl, Tummuru MK, Cao P, Thompson SA, Blaser MJ. “Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains”. J Biol Chem 1994; 269(14): 10566-10573.

12. Haeckel R. “Helicobacter pylori infection. Part 1: Epidemiology, pathobiochemistry, diagnosis and therapy”. Lab Med 1996; 20: 78-84.

13. Megraud F, Brassens-Rabbe MP, Denis F, Belbouri A, Hoa DQ. “Seroepidemiology of Campylobacter pylori infection in various populations”. J Clin Microbiol 1989; 27: 1870-1873.

14. Holcombe C, Omotara BA, Eldridge J, Jones DM. “Helicobacter pylori, the most common bacteria infection in Africa: A random serological study”. Am J Gastroenterol 1992; 87: 28-30.

15. Vaira D, Holton J, Menegatti M. “Review article: Invasive and noninvasive tests for Helicobacter pylori infection”. Alimenty Pharmacol Therapeu 2000; 14(supl. 3): 13-22.