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Patología Revista Latinoamericana

2009, Number 3

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Patol Rev Latinoam 2009; 47 (3)

Frequency of active infection due to cytomegalovirus in critically ill and immunocompromised pediatric patients

Arellano GJ, Jiménez HE, Velásquez GN, Montaño FEH, Moreno GM, Bello GA, Vázquez ME

Language: Spanish
References: 19
Page: 198-203
PDF size: 107.67 Kb.


ABSTRACT

Background: Active infection acquires relevance due to the plausibility to develop cytomegalovirus disease (HCMV), mainly pneumonia which often is fatal.
Objective: To show the frequency of active infection in critical and immunocompromised patients at the Hospital Infantil de Mexico.
Material and methods: Gene ie HCMV protein by polymerase chain reaction (PCR) in blood and in urine was detected at the admission at the pediatric intensive care unit.
Results: Out of 33 patients 13 (39.4%) were positive for HCMV by PCR. In 11/13 bacterial or fungal infections were not detected and 2/13 blood cultures were positive: 1 for Enterococcus faecalis and the other for Enterobacter and Candida tropicalis. Twenty patients were negative for HCMV by PCR; of those, 11 had bacterial bacterial infection, five fungal infections and two Epstein Barr virus active infection and in two microbiological infection could not be detected. HCMV active infection in critical and immunocompromised patients with admission to intensive care unit was identified in 40%.
Conclusions: Early identification of active infection by HCMV is recommended for reducing the risk to develop disease and consequences.


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