2007, Number 4
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Enf Infec Microbiol 2007; 27 (4)
Neonatal candidiasis at Instituto Nacional de Perinatología in a five years period
Reyna FJ, Fragoso DA, Ortiz IFJ, Soriano BD, Bermúdez G, Plazola CN
Language: Spanish
References: 13
Page: 110-113
PDF size: 77.79 Kb.
ABSTRACT
Objective: to assess the epidemiological behavior of infection caused by all species of
Candida gender at Instituto Nacional de Perinatología during a 5 years period.
Methods: we search
Candida sp isolations in all microbiological reports for newborns between 2002 bto 2006. Isolations were made rather from blood, urine or cerebrospinal fluid. We collected demographic characteristics, isolation site, and isolated species. Frequency and incidence of infection were calculated.
Results: we found 35 positive cultures for
Candida sp among 31:6,853 patients (0.45%), 1:221 hospitalized newborns.
Candida albicans was isolated from 40% of cultures while
Candida non albicans corresponded to the 60% remaining.
Candida parapsilosis was isolated from 22% of cultures.
Conclusions: in agreement with previously reported literature,
Candida non
albicans is the most frequently specie isolated among newborns.
REFERENCES
Salavert M, Jarque I, Pemán J. “Los aspectos epidemiológicos cambiantes de la candidemia y sus implicaciones clínico terapéuticas.” Enferm Infecc Microbiol Clin 2006;24 Supl 1:36-45.
Kaufman D, Gurka M, Hazen M, Boyle R, Robinson M, Grossman L. “Patterns of Fungal Colonization in Preterm Infants Weighing Less Than 1000 Grams at Birth.” Pediatr Infect Dis J 2006; 25: 733–737.
Bendel C. “Nosocomial neonatal candidiasis.” Pediatr Infect Dis J 2005;24: 831–832.
Fridkin S, Kaufman D, Edwards J, Shetty S, Horan T. ”Changing Incidence of Candida Bloodstream Infections Among NICU Patients in the United States: 1995–2004.” Pediatrics 2006;117;1680-1687
Sánchez G, Díaz H, Díaz R, Solórzano F, Miranda G, Jiménez C. “Epidemiología de las infecciones sistémicas en el Hospital de Pediatría del Centro Médico Nacional Siglo XXI.” Bol Med Hosp Infant Méx 2004; 61: 289-96.
Colombo AL, Guimarães T, Silva LR, de Almeida Monfardini LP, Cunha AK, Rady P, Alves T, Rosas RC. “Prospective observational study of candidemia in São Paulo, Brazil: incidence rate, epidemiology, and predictors of mortality.” Infect Control Hosp Epidemiol 2007; 28:570-6.
Saiman L, Ludington E, Pfaller M, Rangel-Frausto S, Wiblin T, Dawson J, et al. “Risk factors for candidemia in Neonatal Intensive Care Unit patients.” Pediatr Infect Dis J, 2000;19:319–24
Zaoutis T, Greves H, Lautenbach E, Bilker W, Coffin S. “Risk Factors for Disseminated Candidiasis in Children with Candidemia.” Pediatr Infect Dis J 2004; 23: 635–641.
Khan ZU, Al-Sweih NA, Ahmad S, Al-Kazemi N, Khan S, Joseph L, Chandy R. “Outbreak of fungemia among neonates caused by Candida haemulonii resistant to amphotericin B, itraconazole, and fluconazole.” J Clin Microbiol. 2007 ;45:2025-7
Clerihew L, Lamagni TL, Brocklehurst P, McGuire W “Candida parapsilosis infection in very low birth weight infants.” Arch Dis Child Fetal Neonatal 2007;92:127-9
Smith PB, Steinbach WJ, Cotten CM, Schell WA, Perfect JR, Walsh TJ, Benjamin DK Jr. “Caspofungin for the treatment of azole resistant candidemia in a premature infant.” J Perinatol. 2007 ;27:127-9
Manzoni P, Stolfi I, Pugni L, Decembrino L, Magnani C, Vetrano G et. al; “Italian Task Force for the Study and Prevention of Neonatal Fungal Infections; Italian Society of Neonatology. A multicenter, randomized trial of prophylactic fluconazole in preterm neonates.” N Engl J Med. 2007; 356:2483-95
Chapman RL “Prevention and treatment of Candida infections in neonates.” Semin Perinatol. 2007; 31:39-46.