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Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

1999, Number 4

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Rev Mex Patol Clin Med Lab 1999; 46 (4)

Microalbuminuria and its association with other prognostic factors, in type 2 non-insulin diabetic patients.

Álvarez ER, Padilla GJC, Crespo VN

Language: Spanish
References: 45
Page: 249-154
PDF size: 176.82 Kb.


ABSTRACT

Sixty patients with non-insulin dependent diabetes mellitus (type 2) were studied to evaluating the presence of microalbuminuria and the coexistence of some factors related with the disease. From them, 33.3% presented microalbuminuria. After 10 years of evolution of the disease, 42.4% of patients presented microalbuminuria. Another evaluated factors such as metabolic control (44.4%), presence of retinopathy (51.6%) and diastolic blood pressure higher than 90 mmHg (40%) were associated with the presence of microalbuminuria. We concluded that microalbuminuria was more frequently associated to longer duration of disease, metabolic discontrol, retinopathy and diastolic blood pressure higher than 90 mmHg.


REFERENCES

  1. Humphrey LL et al. Chronic renal failure in non insulin dependent diabetes mellitus. Ann Intern Med 1989; 111: 789-796.

  2. Castellanos I et al. Estudio de la nefropatía diabética en la Provincia de Cáceres. Nefrología 1997; XVII: 103.

  3. Licea M, Santana F. Nefropatía diabética. Revisión bibliográfica en diabetes mellitus. Ciudad Habana: Ed. Ciencias Médicas, 1986.

  4. Deckert T et al. Course of diabetic nephropathy. Acta Endocrinol 1981; 97(supl. 242): 14-15.

  5. Keen H, Chlouverakis C. An immunoassay method for urinary albumin at low concentration. Lancet 1963; II: 913-916.

  6. Vibert GG, Machintosh S. Determination of the penetration of protein through the glomerular barrier in insulin dependent diabetes mellitus. Diabetes 1983; 32(supl.2): 9295.

  7. Mogensen CE. Urinary albumin excretion in early and long term juvenile diabetes. Scand J Clin Lab Invest 1981; 28: 101-109.

  8. Jones SL, Vibert GC. Microalbuminuria: concepts, definition and monitoring. In: CE Mogensen ed. Microalbuminuria. A marker for organ damage. London: Science Press, 1993: 16-26.

  9. Viberti GC, Kein H. The pattern of proteinuria in diabetes mellitus: relevance to pathogenesis and prevention of diabetic nephropathy. Diabetes 1984; 33: 686-692.

  10. Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetes. N Engl J Med 1984; 310: 356-360.

  11. Jarret RJ et al. Microalbuminuria predicts mortality in non insulin dependent diabetes. Diabetic Med 1984; 1: 17-19.

  12. Robert GA et al. Prediabetic pressure and preclinical predisposition to renal disease in Pima indians with non-insulin dependent diabetes mellitus. Diabetes 1995; 9: 212-215.

  13. Licea M et al. Relación de la retinopatía diabética y la presión arterial. Rev Cub Med 1988; 27: 48-55.

  14. Crespo N. Características clínicas de la diabetes mellitus en 250 pacientes de 15 años y más. Rev Cub Med 1978; 17: 685-692.

  15. Amaro S. Características clínicas de la diabetes mellitus en 250 pacientes de 15 años y más. Rev Cub Med 1971; 10: 555-563.

  16. Lewis E. The effect of angiotensin converting enzyme inhibition on diabetic nephropathy. New Engl J Med 1993; 329: 1456-1462.

  17. Mogensen CE. Captopril delays progression to overt renal disease in insulin dependent diabetes mellitus (IDDM) patients with microalbuminuria. (abstract) J Am Soc Nephrol 1992; 3: 336.

  18. Nelson RG et al. Proliferative retinopathy in NIDDM. Incidence and risk factors in Pima Indians. Diabetes 1989; 38: 435-440.

  19. 19.Mattock MB et al. Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 1992; 41: 735-741.

  20. Mateo de Acosta O, Padrón RS. Trastornos del metabolismo de los carbohidratos, lípidos, obesidad y adelgazamiento. En: Manual de diagnóstico y tratamiento en endocrinología y metabolismo. Ciudad Habana. Ed. Científico-Técnica, 1985: 254-503.

  21. L’Esperance FA. Diabetic retinopathy, ophthalmic lasser’s photo-coagulation, photoradiation and surgery 2da. Ed. St Louis: Mosby, 1983.

  22. Pascau M. Metodología bioestadística. 2da ed. Madrid: Paz Montalvo, 1974.

  23. González MT et al. Insuficiencia renal terminal en pacientes diabéticos en Cataluña 1994. Diagnóstico, seguimiento y complicaciones. Resumen Reunión XXVI de la Soc. Española de Nefrología. Nefrología 1996; XVI (supl. 1): 128.

  24. Castelao AM et al. Nefropatía diabética, 13 años de experiencia en el seguimiento conjunto endocrino-nefrológico. Resumen Reunión XXIV de la Soc. Española de Nefrología. Nefrología 1993; XIII: (supl.1): 17.

  25. Mogensen CE. The stages in diabetic renal disease with emphasis in the stage of incipient diabetic nephropathy. Diabetes 1983; 32 (supl 2): 64-78.

  26. Mathiesen CE. The natural course of microalbuminuria in insulin dependent diabetes: A 10 years perspective study. Diabetes Med 1995; 12: 482-487.

  27. United Kingdom Prospective Study Group. Prospective Diabetes Study (UKPDS). Urinary albumin excretion over three years diet treated type II diabetic patients and an association with hypertension. Diabetología 1995; 336: 1021-1029.

  28. Bealty OL et al. Microalbuminuria as identified by a spot morning urine specimen in non-insulin treated diabetes on 8 years follow-up study. Diabetes Med 1995; 12: 261-266.

  29. Standl RY, Steigler H. Microalbuminuria in a random cohort of recently diagnosed type II (non-insulin dependent) diabetic patients living in the greater Munich. Diabetologia 1993; 36: 1017-1020.

  30. Collins UR et al: Prevalence and risk factors for micro and macroalbuminuria in diabetic subjects and entire population of Nauru. Diabetes 1989; 38: 1602-1610.

  31. Dapena F et al. Nefropatía diabetes mellitus tipo II (DMNID). Estudio de prevalencia en población urbana española. Resumen de la XXVI. Reunión de la Soc. Española de Nefrología 1996; (supl 1): 16.

  32. Gall MA et al. Prevalence of micro and macroalbuminuria, arterial hypertension, retinopathy and large vessel disease in European tipo 2 (non-insulin-dependent) diabetic patients. Diabetologia 1991; 34: 655-661.

  33. Dasmahapatra A et al Incipient and overt diabetic nephropathy in American with NIDDM. Diabetic Care 1994; 17: 297-304.

  34. The Diabetes Control and Complications Trial. The effect of intensive treatment of diabetes on the development and progression of long term complications. N Engl Med J 1993; 329: 977-986.

  35. Feldelt R et al. Microalbuminuria, clinical nephropathy and hypertension in diabetes. J Hum Hypertens 1991; 5: 255-263.

  36. Richard P et al. The effect of long term intensified treatment on the development of microvascular complications of diabetes mellitus. N Engl J Med 1993; 329: 304309.

  37. Mathiesen ER et al. Relationship between blood pressure and urinary albumin excretion in development microalbuminuria. Diabetes 1990; 39: 245-249.

  38. Roal J et al. The realtionship between the development and progression of microalbuminuria and arterial blood pressure in type I (insulin-dependent) diabetes mellitus. Diabetes Rev Clin Pract 1992; 16: 221-227.

  39. Viberti GC et al. Raised arterial pressure of proteinuric insulin dependent diabetics. Br Med J 1987; 295: 515-517.

  40. Krolewski AS et al. Predisposition to hypertension and susceptibility to renal disease in insulin dependent diabetes mellitus. N Engl Med J 1988; 318: 140-145.

  41. Parving HH et al. Diabetic nephropathy and arterial hypertension. Diabetes 1983; 32 (supl 8): 83-87.

  42. Luke G et al. Arterial blood pressure during sleep in normotensive and subjects with type I diabetes. Hypertension 1993; 21: 227-235.

  43. Poulsen PL et al. Ambulatory blood pressure in the transition from normal to microalbuminuria. Diabetes 1994; 43: 1248-1253.

  44. Schmitz A et al. Kidney function and cardiovascular risk factors in non-insulindependent diabetic (NIDDM) with microalbuminuria J Intern Med 1990; 228: 347352.

  45. Deckert T. et al. Microalbuminuria. Implications of micro and macrovascular disease. Diabetic Care 1992; 15: 1181-1185.




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