2010, Number 4
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Rev Mex Anest 2010; 33 (4)
Cauda equina syndrome and arachnoiditis from an epidural dose of chloroprocaine injected subdural: Farewell to a local anesthetic
Aldrete JA, Godinez-Cubillo N, Ramirez-Bermejo A, Ghaly RF
Language: English
References: 46
Page: 220-224
PDF size: 377.84 Kb.
ABSTRACT
Chloroprocaine (CHLP) has undergone controversies related to its low pH, preservatives and antioxidants. In a recently delivered parturient scheduled to have a postpartum tubal ligation using the same catheter as for labor, aspiration was negative, The test dose with the anesthetic failed to indicate intrathecal or intravascular injection; delayed onset, led to further doses; after 15 mL had been given, arterial hypotension and sensory block was noted at T5, 10 mL more were given reaching a C5 level after a total dose of 25 mL had been completed. The slow onset suggested subdural injection; subsequently, the patient developed cauda equina and arachnoiditis suggesting that the dose intended for epidural anesthesia eventually entered the intrathecal space.
REFERENCES
Conklin KA, Van der Wall C. Epidural anaesthesia with chloroprocaine. Delayed onset, extensive spread, prolonged duration. Anaesthesia 1980;35:202-4.
Reisner LS, Hochman BN, Plumer MH. Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection. Anesth Analg 1980;59:452-4.
Ravindran RS, Bond VK, Tasch MD, et al. Prolonged neural blockade following regional analgesia with 2-chloroprocaine. Anesth Analg 1980;59:447-51.
Moore DC, Spierdijk J, van Kleef MD, Coleman DL, et al. Chloroprocaine neurotoxicity: four additional cases. Anesth Analg 1982;61:2:155-159.
Winnie AP, Nader AM. Santayana’s prophecy fulfilled. Reg Anesth Pain Med 2001:26:558-64.
Foldes FF, McNall PG. 2-chloroprocaine: a new local anesthetic agent. Anesthesiology 1952;13:287-96.
Foldes FF, Colavinzenso JW, Birch JH. Epidural anesthesia: A reappraisal. Anesth Analg 1956;34:89-100.
Covino BG, Marx GT, Finster M, Zsigmond EK. Prolonged sensory/motor deficits following inadvertent spinal anesthesia. Anesth Analg 1980;59:399-400.
Ravindran RS, Turner MS, Muller J. Neurologic effects of subarachnoid administration of 2-chloroprocaine-CE, bupivacaine, and low pH normal saline in dogs. Anesth Analg 1982;61:3:279-28.
Wang BC, Hillman DE, Spielholz NI, et al. Neurological deficits and Nesacaine-CE- an effect of the anesthetic 2-chloroprocaine, or the antioxidant Na bisulfite? Anesth Analg 1984;63:445-7.
Ready LB, Plumer MH, Haschke RH, et al. Neurotoxicity of intrathecal local anesthetics in rabbits. Anesthesiology 1985;63:4:364-70.
Wang BC, Spielholz NI, Hillman DE, et al. Subarachnoid Na bisulfite (the antioxidand in Nesacaine) causes chronic neurologic deficit. Anesthesiology 1986:57:A194.
Tapia DP, Waxler BJ, Hursh D, Aldrete JA. Effects of Na bisulfite on Sprague Dawley rat sciatic nerve: A preliminary report. Reg Anesth 1990;15:Abst. 90.
Gissen AJ, Datta S, Lambert D. The chloroprocaine controversy I: A hypothesis to explain the neural complications of chloroprocaine epidural. Reg Anesth 1984;9:124-34.
Gissen AJ, Datta S, Lambert D. The chloroprocaine controversy. II Is chloroprocaine neurotoxic? Reg Anesth 1984;9:135-45.
Fibuch EE, Opper SE. Back pain following epidurally administered Nesacaine-MPF. Anesth Analg 1989;69:113-5.
Barsa J, Batra M, Fink BR, Sumi M. Comparative in vivo Study of Local Neurotoxicity of Lidocaine, Bupivacaine, 2-Chloroprocaine, and a Mixture of 2-Chloroprocaine and Bupivacaine. Anesth Analg 1982;61:12:961-7.
Kalichman MW, Powell HC, Reisner LS, et al. The role of 2-chloroprocainbe and Na bisulfate in rat sciatic nerve edema. J Neuropathol Exp Neurology1986;45:566-75.
Myers RR, Kalichman MW, Reisner LS, et al. Neurotoxicity of local anesthetics: Altered perineural permeability, edema and nerve fiber injury. Anesthesiology 1986;64:29-35.
Seravalli CP, Lear E, Cotrell JE. Cell membrane fusion by chloroprocaine. Anesth Analg 1984;63:985-90.
Tanigucgi M, Bollen AW, Drasner K. Na bisulfite, scapegoat for chloroprocaine neurotoxicity? Anesthesiology 2004;100:85-91.
Lambert DH, Strichartz GR. In defense of in vitro findings. Anesthesiology 2004;101:1246-7.
Moore DC. Labeling package insert: meaning by the FDA of not recommended, not indicated and off-label use. Anesthesiology 2006;104:104-6.
Horlocker TT, Wedel DJ. Local anesthetic toxicity-does product liability reflect the risk? Reg Anesth Pain Med 2002;27:562-7.
Myers RR, Olmarker K. Anatomy of DRG, intrathecal nerve roots and epidural nerves with emphasis on mechanisms of neurotoxicity. In: Spinal Drug Deliver, T.L. Yaksh (ed). Elsevier Science, Amsterdam. 1999;115-31.
Chestnut DH. Obstetric Anesthesia: principles and Practice. 3rd edition. Mosby, St. Louis. 2004:415.
Reynolds F, Speedy HM. The subdural space: the third place to go astray. Anaesthesia 1990;45:120-3.
Pan PH, Board TD, Owen TD, et al. Incidence and characteristics of failures in obstetrical neuraxial analgesia and anesthesia: a retrospective analysis of 19,259 deliveries. Int J Obstet Anesth 2004;13:227-33.
Balistieri PJ. Epidural chloroprocaine-standard of care for postpartum tubal ligation? Anesth Analg 2005;101:1241.
Halpern SH, Douglas MJ. Evidence-based obstetric anesthesia. Blackwell, Malden, MS. 2005;239-44.
Na KB, Kopacz DJ. Spinal CHLP solutions: density at 37 degrees C and titration. Anesth Analg 2004;98:70-4.
Yoos JR, Kopacz DJ. Spinal 2-CHLP for surgery: an initial 10 month experience. Anesth Analg 2005;100:553-8.
Smith KN, Kopacz DJ, McDonald SB. Spinal 2-CHLP: a dose ranging study and the effects of added epinephrine. Anesth Analg 2004;98:81-8.
Vath JS, Kopacz DJ. Spinal 2CHLP: the effect of added fentanyl. Anesth Analg 2004;98:89-94.
Warren DT, Kopacz DJ. Spinal 2CHLP: the effect of added dextrose. Anesth Analg 2004;98:95-101.
Davis BR, Kopacz DJ. Spinal 2_CHLP: the effect of added clonidine. Anesth Analg 2005;100:559-65.
Yoos JR, Kopacs DJ. Spinal 2-CHLP: a comparison with small dose bupivacaine in volunteers. Anesth Analg 2005;100:566-72.
Gonter AF, Kopacz DJ. Spinal 2-CHLP a comparison to procaine in volunteers. Anesth Analg 2005;100:573-9.
Kouri ME, Kopacz DJ. Spinal 2-CHLP: a comparison with lidocaine in volunteers. Anesth Analg 2004;98:70-4.
Casati A, Danelli G, Berti M, et al. Intrathecal 2-chloroprocaine for lower limb outpatient surgery: a prospective, randomized, double-blind, clinical evaluation. Anesth Analg 2006;103:234-8.
Casati A, Fanelli G, Danelli G, et al. Spinal anesthesia with lidocaine or preservative-free chloroprocaine for outpatient knee arthroscopy: A prospective, randomized, double blind comparison. Anesth Analg 2007;104:959-64.
Drasner K. Chloroprocaine spinal anesthesia: Back to the future. Anesth Analg 2005;100:549-52.
Palas TAR. 1% chloroprocaine for spinal anesthesia: an ideal local anesthetic drug for short surgical procedures? Reg Anesth Pain Med 2007;32:8.
Hejtmaneck M, Pollock JE. Spinal 2-chloroprocaine for outpatient surgery-experience with 600 anesthetics. ASRA Congress 2008, Abstract ID A-24.
Ruben SS. Retraction of 10 published articles in Anesthesia and Analgesia. Notice of Retraction 2009;109:1350.
Struys MMR, Fechner J, Schuttler J, Schilden H. Requested retraction of six studies on the PK/PD and tolerability of fospropofol. Anesth Analg 2010;110:1240.