2010, Number 4
<< Back Next >>
Rev Mex Pediatr 2010; 77 (4)
Family history of asthma: Influence in the starting and evolution of the disease
Coronel CC
Language: Spanish
References: 23
Page: 148-151
PDF size: 139.58 Kb.
ABSTRACT
Objective. To study the family influence of asthma in children and its relation to this disease in the children and its evolution.
Material and methods. One hundred and sixty two children below 15 years with attended for asthma in the Guáimaro Hospital were studied from January-December of 2008.
Results. When the family history of asthma was present in three or more members of the family the disease started at the 10.2 months the patients suffered 6.2 crisis in a year and were admitted annually in the hospital 2.8 times. When the family history was in the father the disease began at 6.6 months age and had more times in the hospital, but when both parents were asthmatics, the children suffered 6.4 crisis and were admitted 2.7 by year, and in 50% of them the disease was classified as persistent asthma.
Conclusions. As higher is the number of members with asthma in the family, the frequency, age beginning, severity of this disease and hospitalizations of children with asthma is higher. When both parents are asthmatics their children could have earlier this disease, have three or more asthmatic crisis and more hospitalizations for year. When both fathers were asthmatics, the crisis and hospitalization were more frequent in the child, and the disease use to be more severe.
REFERENCES
Rojo M. Asma bronquial. En: De la Torre E, González JA, Gutiérrez JA, Jordán J, Pelayo EJ. Neumología. Pediatría. Editorial Ciencias Médicas: Ciudad de la Habana; 2005: 111-46.
Asociación Mexicana de Pediatría. Segundo Consenso Mexicano de Asma en Pediatría. Acta Pediatr Mex 2002; 23(Supl 1): 1-39.
López G, Juárez F, Rojas A, García R. Inmunogenética del asma. Participación de los genes HLA en la susceptibilidad al asma. Acta Pediatr Mex 2005; 26(1): 29-34.
Wiesch DG, Meyers DA, Bleecker ER. Genetics of asthma. J Allergy Clin Immunol 1999; 104: 895-901.
Gudiel J, Gudiel A, Tincopa L, Pajuelo M, Quirico M, Polo C et al. Aplicación de índices predictores de asma en sibilantes precoces. Revista Peruana Pediatría 2004: 5-11.
Castro-Rodríguez JA, Holberg JC, Wright AL, Martínez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162: 1403-06.
O her C. Perspectives on the past decade of asthma genetics. J Allergy Clin Immunol 2005; 116(2): 274-8.
Zaas D, Schwartz DA. Genetics of environmental asthma. Semir Respir Crit Care Med 2003; 24(2): 185-6.
Howard TD , Wiesch DG, Koppelman GH, Postma DS, Meyers DA, Bleecker ER. Genetics of allergy and bronchial hyperreponsiveness. Clinical Experimental Allergy 1999; 29(Suppl 2): 86-9.
Holloway W, Beghé B, Holgate T. The genetic basis of atopic asthma. Clinical Experimental Allergy 1999; 29: 1023-32
Abdo A, Cué M, Álvarez M. Asma bronquial; factores de riesgo de las crisis y factores preventivos. Rev Cubana Med Gen Integr 2007; 23(3) http://bvs.sld.cu/revistas/mgilvol23_3_07/mgi10307.htm
Recabarren LA, Cárdenas HS. Factores de riesgo de asma infantil en niños que asisten al Programa de Control de Asma del Hospital III Yanahuara Essalud - Arequipa. Enfermedades del Tórax 2003; 46(2): 118-125.
Rojas A. Factores de riesgo para el desarrollo de asma y otras enfermedades alérgicas. Rev Allerg Asma Immunol 2002; 11(2): 67-75.
Chandra KR. Five-year follow-up of high-risk infants with family history of allergy who were exclusively breast-fed or fed partial whey hydrolysate, say, and conventional cow’s milk formulas. J Pediatr Gastroenterol Nutr 1997; 24: 442-446.
Rodríguez A, Núñez E, Pérez AG, Cruz J, Valencia E. Factores que determinan el mal pronóstico y la exacerbación del asma en niños que asisten a consulta de Alergología Pediátrica. Rev Cubana Pediatr 2007; 79(1): http://bvs.sld.cu/revistas/ped/vol79_01_07/ ped03107.htm).
Sheriff A. Risk factors associations with wheezing patterns in children followed longitudinally from birth to (1/2) years. Int Epidemiol 2001; 30(6): 1473-84.
Haby MM. Asthma in preschool children prevalence and risk factors. Torax 2001; 56(8): 89-90.
T ariq SM. The prevalence and risk factors atopy in early childhood; a whole population birth cohort study. J Allergy Clin Immunol 1998; 101(5): 587-93.
O ber C. Do genetics play a role in the pathogenesis of asthma? J Allergy Clin Immunol 1998; 101: S417-S420.
Wiesch DG, Meyers DA. Strategies for analyzing genotype-phenotype relationships in asthma. J Allergy Clin Immunol 2000; 105: S482-6.
Howard T, Wiesch D, Koppelman H, Postma D, Meyers D, Bleecker E. Genetics of allergy and bronchial hyperresponsiveness. Clin Exp Allergy 1999; 29(Suppl 2): 86-89.
Montoya CJ, Ayala AM. Aproximación a la genética del asma bronquial. Revista de Inmunoalergia 2001; 10(1): http://encolombia. com/medicina/alergia/alergiavol10-001revaprox.htm
López PIR. Herencia y asma. http://www.bvs.sld.cu/revistas/ped/vol80_1_08/ped09108.htm