2010, Number 5
<< Back Next >>
Acta Ortop Mex 2010; 24 (5)
Functional results of nervous reconstruction in an upper limb. Report of a multicentric trial
Herrera-Tenorio JG, Chávez-Galván CR, Sesma-Villalpando RA, Farías-Castañeda RE, Núñez-Fernández AI
Language: Spanish
References: 38
Page: 291-297
PDF size: 554.20 Kb.
ABSTRACT
Objective: To assess the functional results of nerve reconstruction with autologous interfascicular nerve grafts in a thoracic limb.
Material and methods: From January 1999 to December 2006. Complete nerve injuries of the radial, median and ulnar nerves. Follow-up was at least 12 months. Variables: age, nerve defect length, location, interval between the injury and the treatment, mechanism, injuries, and adjunctive treatments. The procedures were performed by the authors. Nine and 10-0 sutures were used. The Medical Research Council System (MRCS) scale was used for the functional measurement. The χ
2 test was applied to variables and functional results.
Results: 43 patients, 48 nerves, mean age 26.7 years; 29 males and 14 females. Nineteen injuries occurred in the ulnar nerve (39.5%), 18 in the median nerve (37.5%) and 11 in the radial nerve (23%). Five patients had injury of the median and ulnar nerves. Twenty three injuries involved the wrist (53.4%), 7 the forearm (16.2%) and 12 the arm (27.9%). The mean time elapsed between the injury and the treatment was 42.09 days. The mean size of the nerve defect was 4.4 cm. The mean follow-up was 17.5 months. Forty two patients had associated injuries and 37 received adjunctive treatment. Motor function: Results were good in 15 patients (31.2%), fair in 21 (43.8%), poor in 10 (20.8%) and bad in 2 (4.2%). Sensory function: Results were good in 36 nerves (75%), fair in 4 (8.3%), poor in 6 (12.5%) and bad in 2 (4.2%).
Discussion: The results were similar to those reported in the literature.
Conclusions: Good results were obtained in gaps ≤ 5 cm, in cases without arterial injury and when the time to treatment did not exceed 40 days (p ‹ 0.05). The age, the nerve and the site of injury were not influencing factors.
REFERENCES
Omer GE: Injuries to nerves of the upper extremity. J Bone Joint Surg Am 1974; 56: 1615-24.
Trumble T, McCallister W: Repair of peripheral nerve defects in the upper extremity. Hand Clin 2000; 16 (1): 37-51.
Dvali L, Mackinnon S: The role of microsurgery in nerve repair and nerve grafting. Hand Clin 2007; 23: 73-81.
Lundborg G: A 25-year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance. J Hand Surg 2000; 25A: 391-414.
Clark WL, Trumble TE, Swiontowski MF, Tencer AF: Nerve tension and blood flow in a model of immediate and delayed repairs. J Hand Surg [Am] 1992; 17: 677-87.
Hall S: Nerve repair: A neurobiologist’s view. J Hand Surg [Br] 2001; 26: 129-36.
Jabaley ME: Internal topography of peripheral nerves as related to repair. In: Gelberman RH (ed): Operative nerve repair and reconstruction. Philadelphia, JB Lippincott, 1991: 231-40.
Myckatyn TM, MacKinnon SE: A review of research endeavors to optimize peripheral nerve reconstruction. Neurol Res 2004; 26 (2): 124-38.
Dornseifer, et al: Surgical therapy of peripheral nerve lesions: Current status and new prospectives. Zentralbl Neurochir 2007; 68: 101–10.
Dvali L, Mackinnon S: Nerve repair, grafting and nerve transfers. Clin Plast Surg 2003; 30 (2): 203-21.
Millesi H: Interfascicular nerve grafting. Orthop Clin North Am 1981; 12: 287-301.
Birch R: Nerve repair. In: Green DP, Hotchkiss RN, Pederson WC: Green’s operative hand surgery, 5th ed. Elsevier-Churchill Livingstone, 2005.
Chow JA, Van Beek AL, Bilos ZJ, Meyer DL, Johnson MC: Anatomical basis for repair of ulnar and median nerves in the distal part of the forearm by group fascicular suture and nerve-grafting. J Bone Joint Surg 1986; 68A: 273-80.
Millesi H, Meissl G, Berger A: Further experience with interfascicular grafting of the median, ulnar and radial nerves. J Bone Joint Surg Am 1976; 58: 209-18.
Millesi H: Techniques for nerve grafting. Hand Clin 2000; 16(1): 73-91.
Millesi H: The nerve gap. Theory and clinical practice. Hand Clin 1986; 2 (4): 651-63.
Myckatyn TM, Mackinnon SE: Surgical techniques of nerve grafting (Standard/Vascularized/Allograft) Oper Tech Orthop 2004; 14: 171-8.
Lundborg G, Rosen B, Dahlin L, et al: Tubular versus conventional repair of median and ulnar nerves in the human forearm: Early results from a prospective, randomized clinical study. J Hand Surg [Am] 1997; 22: 99-106.
Mackinnon SE: New directions in peripheral nerve surgery. Ann Plast Surg 1989; 22: 257-73.
Ruijs AC, Jaquet JB, Kalmijn S, Giele H, Hovius SE: Median and ulnar nerve injuries: A meta-analysis of predictors of motor and sensory recovery after modern microsurgical nerve repair. Plast Reconstr Surg 2005; 116 (2): 484-94.
Frostick SP, Yin Q, Kemp GJ: Schwann cells, neurotrophic factors and peripheral nerve regeneration. Microsurgery 1998; 18: 393-405.
Hess JR, Brenner MJ, Fox IK, Nichols CM, Myckatyn TM, Hunter DA, Rickman SR, MacKinnon SE: Use of cold-preserved allografts seeded with autologous Schwann cells in the treatment of a long-gap peripheral nerve injury. Plast Reconstr Surg 2007; 119 (1): 246-59.
Mackinnon SE, Hudson AR, Bain JR: The peripheral nerve allograft: An assessment of regeneration in the immunosuppressed host. Plast Reconstr Surg 1987; 79: 436-46.
Guerra W, Baldauf J, Schroeder W: Long-term results after microsurgical repair of traumatic nerve lesions of the upper extremities. Zentralbl Neurochir 2007; 68: 195-9.
Maggi SP, Lowe JB 3rd, MacKinnon SE: Pathophysiology of nerve injury. Clin Plast Surg 2003; 30 (2): 109-26.
Hakstian RW: Funicular orientation by direct stimulation: An aid to peripheral nerve repair. J Bone Joint Surg Am 1968; 50: 1178-86.
Hiroyuki K, et al: Functional results of low median and ulnar nerve repair with intraneural fascicular dissection and electrical fascicular orientation. J Hand Surg 1998; 23A: 471-82.
Sunderland S: The intraneural topography of the radial, median and ulnar nerves. Brain 1945; 68(4): 244-98.
Sunderland S: Cutaneous nerve autografts. In: Nerve and nerve injuries, 2nd ed. Edinburgh, Churchill Livingstone, 1978: pp. 618-23.
Millesi H, Meissl G, Berger A: The interfascicular nerve-grafting of the median and ulnar nerves. J Bone Joint Surg Am 1972; 54: 727-50.
Kallio PK, Vastamäki M: An analysis of the results of late reconstruction of 132 median nerves. J Hand Surg [Br] 1993; 18 (1): 97-105.
Weber RV, MacKinnon SE: Bridging the neural gap. Clin Plast Surg 2005; 32 (4): 605-16.
Vanderhooft E: Functional outcomes of nerve grafts for the upper and lower extremities. Hand Clin 2000; 16; 93-104.
Young HL, et al. Sural nerve autografts for high radial nerve injury with nine centimeter or greater defects. J Hand Surg 2008; 33A: 83-6.
Lloyd BM, Luginbuhl RD, Brenner MJ, Rocque BG, Tung TH, Myckatyn TM, Hunter DA, MacKinnon SE, Borschel GH: Use of motor nerve material in peripheral nerve repair with conduits. Microsurgery 2007; 27 (2): 138-45.
Narakas AO: The use of fibrin clot glue in repair of peripheral nerves. Orthop Clin North Am 1988; 19: 187-99.
Rosén B, Göran L: A model instrument for the documentation of outcome after nerve repair. J Hand Surg 2000; 25A: 535-43.
Rosén B, Lundborg G: The long term recovery curve in adults after median or ulnar nerve repair: a reference interval. J Hand Surg [Br]. 2001; 26 (3): 196-200.