de la Torre RFE

Language: Spanish
References: 67
Page: 332-342
PDF size: 686.32 Kb.

ABSTRACT

In the past 60 years there has been a development of several classifi cations and enlightening information on premalignant squamous lesions of the cervix uteri. Since the simultaneous disclosure that human papillomavirus (HPV) was involved in cervical dysplasias and socalled “koilocytic atypias” by Meisels et al. and Purola y Salvia 32 years ago, the growth of knowledge and technology is enormous. Along this time the lack of reproducibility and discordance of cytological and histopathological diagnosis has been evident. Two breakpoints were the proposal of the Richart’s nomenclature for CIN and the cytological classifi cation of Bethesda. Advances in immunocyto-histochemistry and molecular biology imprinted the new style of histological and cytological diagnosis complemented with molecular markers, from HPV genome to protein markers for molecular disarrangements during the oncogenic process: p16. Also the identifi cation of overexpression of proliferation and cell maturation markers: p63, Ki-67 and cyclin E. This conceptual and technological evolution is discussed and an up-todate review of the histological criteria of diagnosis and the use of the current molecular markers as well.

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