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Boletín Médico del Hospital Infantil de México

2010, Number 6

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Bol Med Hosp Infant Mex 2010; 67 (6)

Anti-HLA antibodies and acute renal graft rejection in children

Galeas RA, Gomezchico-Velasco R, Valverde S, Ramón-García G, Velásquez-Jones L, Romero-Navarro B, Hernández AM, Vargas A, De Leo C, Medeiros M

Language: Spanish
References: 38
Page: 492-502
PDF size: 429.73 Kb.


ABSTRACT

Background. Although new immunosuppressive therapies have significantly improved the clinical progression of kidney transplants, acute and chronic rejection continue to limit long-term graft survival. Despite this, the aim of the study was to determine the presence of human leukocyte antigen (HLA) antibodies class I and class II in children with acute renal graft rejection.
Methods. Patients with graft rejection were included in the study. A serum sample for anti-HLA antibody measurement class I and II by Luminex was taken at the time of renal biopsy.
Results. Seventeen patients (81%) had cellular rejection and four (19%) antibody-mediated rejection. Mean post-transplant time of rejection was 18.7 months and 36.7 months for humoral rejection and cellular rejection, respectively.
Eleven patients (52.3%) had donor specific (DS) antibodies. Anti-HLA class I DS was found in six patients including the four patients with humoral rejection (Fisher exact test p =0.004); 95.2% had non-DS antibodies.
Conclusions. Of the children with acute renal graft rejection, 95% have anti HLA antibodies (DS and/or non-DS). Anti-HLA DS class I are more frequent in humoral rejection.


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