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2005, Number 2

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Rev Med Inst Mex Seguro Soc 2005; 43 (2)

A case of small-cell malignant melanoma in a pregnant patient

Calderón GAL, Dragustinovis VIY, Castelán MEE, Zavala PÁ

Language: Spanish
References: 14
Page: 161-165
PDF size: 73.95 Kb.


ABSTRACT

Introduction: Malignant melanoma (MM) is an aggressive neoplasm that may affect pregnant women. Malignant melanoma with small-cell morphology (MMSCM) is a rare variant of MM that can cause confusion in its diagnosis.
Objective: To report a fatal case of MMSCM in a pregnant woman, highlighting immunohistoche-mistry (IHC) as a very useful tool in the final diagnosis.
Clinical case: A 22-year-old pregnant female pre-sented with a 5-cm cutaneous tumor in her right leg. The lesion was excised but the patient refused any further therapy. The natural outcome of this neoplasm occurred with local recurrence and multiple metastases to the lungs, liver, and kidneys.
Conclusions: MM should be included in the diffe-rential diagnosis of small-cell cutaneous tumor, and IHC is mandatory for diagnosis confirmation. The recommended suggested screening includes, as a minimum, one sensitive marker (S-100 protein) and one specific (HMB45) marker for melanogenesis.


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