Romero G, Méndez I, Tello A, Torner C

Language: Spanish
References: 26
Page: 222-227
PDF size: 105.03 Kb.

ABSTRACT

Objective: this study was designed to characterize the differences between normal children and those with neonatal encephalopathy, regarding the brain auditory evoked potentials (BAEPs), these differences may be which may be used as an exploratory guide of the brain stem condition. Methods. A sample of 34 infants suffering from neonatal encephalopathy (NE) and 34 healthy children were studied. Using the BAEP technique, the latencies and amplitudes of the waves I, II, III, and V, were measured, as well as the intervals I-III, III-V, and I-V. The differences between groups were evaluated through a analysis of variance and a conglomerate analysis. Results: the latencies of the waves I, II, and V, were more prolonged in the group of children with NE than in the group of healthy children, and the amplitudes of the NE group were larger than controls. The intervals I-III and I-V and waves III and V, were also different in both groups. The conglomerate analysis formed three different functional profiles in alI children: rapid, intermediate, and a slow time responders. Slow responders were exclusively found in children with NE. Conclusions. The BAEPs of infants with NE showed larger wave latencies and increased wave amplitudes, when compared to normal children. These statistical analyses classified them in different functional profiles, which may be useful in detecting children with greater risk of neurological sequels.

REFERENCES

1. González de Dios J, Moya M, Vioque J. Factores de riesgo predictivos de secuelas neurológicas en recién nacidos de término con asfixia perinatal. Rev Neurol 2001;32(3):210-6.

2. Rufo Campos M, Palencia Luaces R. Encefalopatía hipóxicoisquémica del recién nacido a término. Recientes avances, marcadores de hipoxia y opciones terapéuticas. Rev Neurol 2000;31(7):617-23.

3. Meberg A, Broch H. Etiology of cerebral palsy. J Perinat Med 2004;32(5):434-9.

4. Carli G, Reiger I Evans N. One-year neurodevelopmental outcome after moderate newborn hypoxic ischaemic encephalopathy. J Paediatr Child Health 2004;40(4):217-20.

5. Fernández-Carrocera L, Jonguitud A, Ortigosa C, Barrera R, Martínez C, Ibarra M, et al. El neurodesarrollo a los dos años de vida de neonatos tratados en una unidad de cuidados intensivos neonatales. Rev Panam Salud Pública 1999; 5(1):29-35.

6. Miller S, Latal B, Clark H, Barnwell A, Glidden D, Barlovich J, et al. Clinical signs predict 30 month neurodevelopmental outcome after neonatal encephalopathy. Am J Obste Gynecol 2004; 190:93-9.

7. Volpe J. Perinatal Hypoxic-lschemic. En Volpe, Joseph J, editor. Neurology of the newborn. 4th ed. Philadelphia: Saunders, 2001.

8. Cruz E, Guerra A, Barreras J. Evaluación del neurodesarrollo a los dos años de edad en niñas y niños que presentaron encefalopatía hipóxico isquémica durante la etapa neonatal. Revista de la facultad de ciencias de la salud. 2006;2(1):95-101.

9. Hecox K. Neurologic applications of the Auditory brainstem response to the pediatric age group. En Jacobson, Jonh T, editor. The Auditory Brainstem Response. Boston: College-Hill Press 1985;287-96.

10. Karmel BZ, Gardner JM, Zapulla RA, Magnano CL, Brown EG. Brain-stem auditory evoked responses as indicators of early brain insult. Electroencephalogr Clin Neurophysiol 1988; 71(6):429-42.

11. Jiang ZD, Tierney TS. Long-term effect of perinatal and postnatal asphyxia on developing human auditory brainstem responses: brainstem impairment. Int J Pediatr Otorhinolaryngol 1996;34(12):111-27.

12. Pasman JW, Rotteveel JJ, Maassen B, de Graaf R, Visco YM. Diagnostic and predictive value of auditory evoked responses in preterm infants: II Auditory evoked responses. Pediatr Res 1997;42(5):670-7.

13. Romero G, Mandujano M, Méndez 1, Sánchez C. Brain-stem auditory evoked potentials in children with perinatal encephalopathies. Clin Neurophysiol 2000:111(11):1091-6.

14. Du Plessis AJ, Volpe JJ. Perinatal brain injury in the preterm and term newborn. Curr Opin Neurol 2002;15(2):151-7.

15. De Vries LS, Pierrat V, Eken P. The use of evoked potentials in the neonatal intensive care unit. J Perinat Med 1994;22(6):547-55.

16. Majnemer A, Rosenblatt B. Evoked potentials as prediction of outcome in neonata! intensive care unit survivors: review of the literature. Pediatr Neurol 1996; 14(3):189-95.

17. Jiang ZD, Tierney TS. Development of human peripheral hearing revealed by brainstem auditory evoked potentials. Acta Paediatr 1995,84(11):1216-20.

18. Nuwer MR, Aminoff M, Goodin D, Matsuoka S, Mauguiere F, Starr A, Vibert JF. IFCN recommended standards for brainstem auditory evoked potentials. Report of an IFCN committee. International Federation of Clinical Neurophysiology Electroencephalogr. Clin Neurophysiol 1994; 91(1):12-7.

19. Pratt H, Aminoff M, Nuwer MR, Starr A. Short-latency auditory evoked potentials. The International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol Suppl 1999;52:69-77.

20. Kashigan SK. Multivariate statistical analyses: a conceptual introduction. Cluster Analysis. 2a ed. New York: Radius press, 1991.

21. Salamy A, McKean CM, Buda FB. Maturational changes in auditory transmission as reflected in human brain stem potentials. Brain Res 1975;96(2):361-6.

22. Miller G, Skouteli H, Dubowitz LM, Lary S. The Maturation of the auditory brainstem response compared to peripheral nerve conduction velocity in preterm and full-term infants. Neuropediatrics 1984;15(1):25-7.

23. Psatta DM, Matei M. Age dependent amplitude variation of brain-stem auditory evoked potentials. Electroencephalogr Clin Neurophysiol 1988;71(1):27-32.

24. Ruth RA, Lambed PR. Auditory evoked potentials. Otolaryngol Clin North Am 1991;24(2):349-70.25.

25. Sugama S, Ariga M, Hoashi E, Eto Y. Brainstem cranial-nerve lesions in an infant with hypoxic cerebral injury. Pediatr Neurol 2003;29(3):256-9.

26. Jiang Z, Brosi D, Hua Z, Chen C, Wilkinson A. Brainstem auditory function at term in preterm babies with and without perinatal complications. Pediatric Research 2005,58(6):1164-9.