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Instituto Nacional de Salud Pública

2009, Number 3

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salud publica mex 2009; 51 (3)

Sexual maturation and metabolic profile among adolescents and children of the Health Worker Cohort Study in Mexico

Katon JG, Flores YN, Salmerón J

Language: English
References: 26
Page: 219-226
PDF size: 145.34 Kb.


ABSTRACT

Objective. Our objective was to investigate the associations between level and timing of sexual development with metabolic profile in a cohort of Mexican adolescents in central Mexico. Material and Methods. Baseline data from children between the ages of 7 and 17 years (n= 582) who participated in the Health Worker Cohort Study, was used. The study participants included children of workers at the Mexican Institute of Social Security (IMSS) and the National Institute of Public Health, both located in Cuernavaca, in addition to children of workers at the Universidad Autónoma del Estado de México in Toluca who were enrolled between March 2004 and April 2006. Multiple linear regressions with robust estimates of variance, were used adjusting for specific covariates. Results. Both pubertal boys and girls, compared to their pre-pubertal counterparts, had higher body mass index (girls: 4.59 kg/m2, p‹0.0001; boys: 1.12 kg/m2, p= 0.05) and percent body fat (girls: 3.61, p‹0.0001; boys: 1.48, p= 0.0001). A significant difference in level of insulin resistance (homeostasis model assessment, HOMA) was detectable among girls (0.92, p‹0.0001). Conclusions. Timing and levels of sexual development were significantly associated with adverse differences in several critical anthropometric and metabolic parameters.


REFERENCES

  1. Moran A, Jacobs DR Jr, Steinberger J, Hong CP, Prineas R, Luepker R, et al. Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 1999;48:2039-2044.

  2. Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes 2001;50:2444-2449.

  3. Morrison JA, deGroot I, Edwards BK, Kelly KA, Mellies MJ, Khoury P, et al. Lipids and Lipoproteins in 927 School Children, Ages 6-17 Years. Pediatrics 1978;62:990-995.

  4. Ogden CL, Flegal KM, Carroll MD, Johson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002;288:1728-1732.

  5. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the Third National Health and Nutrition Examination Survey. JAMA 2002;287:356-359.

  6. National Institutes of Health. 2001. The Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Bethesda (MD): National Institutes of Health. NIH Publication 01-3670.

  7. Halley Castillo E, Borges G, Talavera JO, Orozco R, Vargas-Alemán C, Huitrón-Bravo G, et al. Body mass index and the prevalence of metabolic syndrome among children and adolescents in two Mexican populations. J Adolesc Health 2007;40(6):521-526.

  8. Goran MI, Bergman RN, Cruz ML, Watanabe R. Insulin resistance and associated compensatory responses in African-American and Hispanic children. Diabetes Care 2002;25:2184-2190.

  9. Sun SS, Schubert CM, Chumlea WC, Roche AF, Kulin HE, Lee PA, et al. National estimates of the timing of sexual maturation and racial differences among US children. Pediatrics 2002;110:911-919.

  10. Frontini MG, Srinivasan SR, Berenson GS. Longitudinal changes in risk variables underlying metabolic syndrome X from childhood to young adulthood in female subjects with a history of early menarche: The Bogalusa Heart Study. Int J Obes 2003;27:1398-404.

  11. Himes JH. Examining the evidence for recent secular changes in the timing of puberty in US children in light of increases in the prevalence of obesity. Mol Cell Endocrinol 2006;254-255:13-21.

  12. Ibanez L, Potau N, Chacon P, Pascual C, Carrascosa A. Hyperinsulinaemia, dyslipaemia and cardiovascular risk in girls with a history of premature pubarche. Diabetologia 1998;41:1057-1063.

  13. Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus American girls. Pediatrics 2002;110:903-910.

  14. Tanner JM. Normal growth and techniques of growth assessment. Clin Endocrinol Metab 1986;15(3):411-451.

  15. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C.. Homeostasis model assesment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005;115:e500-e503.

  16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.

  17. Saucedo R, Basurto L, Zarate A, Martínez C, Hernandez M, Galván R. Effect of estrogen therapy on insulin resistance and plasminogen activator inhibitor type 1 concentrations in postmenopausal women. Gynecol Obstet Invest 2007;64(2):61-64.

  18. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362–2374.

  19. Glen ED, Sierra ML, Xiao-Hua Z. Prevalence and trends of a metabolic syndrome phenotype among U.S. adolescents, 1999–2000. Diabetes Care 2004;2:2438–2443.

  20. Ferranti SD, Gauvreau K, Ludwig DS, Neufeld EJ, Newburger JW, Rifai N. Prevalence of the metabolic syndrome in American adolescents. Findings from the Third National Health and Nutrition Examination Survey. Circulation 2004;110:2494 –2497.

  21. Da Silva RCQ, Miranda W, Chacra AR, Dib SA. Metabolic syndrome and insulin resistance in normal glucose tolerant Brazilian adolescents with family history of type 2 diabetes. Diabetes Care 2005;28;716–718.

  22. The International Physical Activity Questionnaire 2005. Available: http://www.ipaq.ki.se

  23. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35:1381-1395.

  24. Osuna-Ramírez I, Hernández-Prado B, Campuzano JC, Salmerón J. Body mass index and body image perception in a Mexican adult population: the accuracy of self-reporting. Salud Publica Mex 2006;48(2):94-103.

  25. Ball G, Weigensberg MJ, Cruz ML, Shaibi GQ, Kobaissi H, Goran MI. Insulin sensitivity, insulin secretion and b-cell function during puberty in overweight Hispanic children with a family history of type 2 diabetes. Int J Obes 2005;29:1471-1477.

  26. Mahan LK, Escott-Stump S. Krause’s food, nutrition, and diet therapy. 9th ed. Philadelphia (PA): WB Saunders, 1996.




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