2009, Number 1
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salud publica mex 2009; 51 (1)
Maternal MTHFR polymorphisms and risk of spontaneous abortion
Rodríguez-Guillén MR, Torres-Sánchez L, Chen J, Galván-Portillo M, Blanco-Muñoz J, Aracely AM, Silva-Zolezzi I, Hernández-Valero MA, López-Carrillo L
Language: English
References: 48
Page: 19-25
PDF size: 162.94 Kb.
ABSTRACT
Objective. To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C›T and 1298 A›C).
Material and Methods. We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC.
Results. Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (
OR 677TT vs. CC/CT=5.0; 95%
CI: 1.2, 20.9 and
OR 1298 AC vs. AA=5.5; 95%
CI: 1.1, 26.6).
Conclusions. Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins.
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