Vásquez-Márquez PI, Castañeda-Trujillo R, Castellanos-Olivares A

Language: Spanish
References: 21
Page: 154-159
PDF size: 301.98 Kb.

ABSTRACT

Introduction: Muscular, component relaxation of the surgical anesthetic procedure, facilitates: orotraqueal intubation, mechanical ventilation producing optimal conditions for surgical manipulation. Objective: To demonstrate that times of beginning and duration of action of pipecuronio it is greater than pancuronio in prolonged surgery. Design: Clinical controlled trial. Material and methods: Previous authorization of the Local Committee of Investigation 30 patients submissive otolaryngologic surgery, of 3-8 hours of duration; divided randomly in group 1, receiving pipecuronio 55 µg/kg, group 2, 70 µg/kg of weight received pancuronio. Principal measures: time of beginning and duration of action, arterial tension and frequency cardiac. Results: Group 1 with 15 patients 5 men and 10 women age 32 ± 12 years, weight 60.4 ± 9 kg, surgical time = 195 ± 55 and anesthetic 226 ± 67 min. Beginning and duration of action 9.9 ± 4.9, 97.5 ± 23.5 respectively (p = 0.03). The group 2 with 15 patients 6 men and 9 women age average 33 ± 11 years, weight 59.9 ± 9 kg, times: surgical 161 ± 32 min, anesthetic = 188 ± 38 min. Beginning and duration of action 6.7 ± 2, 86.6 ± 28.4 respectively. Conclusions: The times of beginning and duration of action of pipecuronio it was greater than bromide of pancuronio, requiring smaller number of dose in surgery of more than three hours of duration.

REFERENCES

1. Gal TJ, Surratt PM. Resistance to brathing in healthy subjects following endotracheal intubation under topical anesthesia. Anesth Analg 1980;59:270-4.

2. Hollander AA, Luyekx C, Barvais L. Clinical evaluation of atracurium requirement for stable muscle relaxation during surgery, lack of age-related effects. Anesthesiology 1983;59:237.

3. Nalda FMA. De la neuroleptoanalgesia a la anestesia analgésica en: Nalda FMA. Neuroleptoanalgesia ed. única, México, edit. Salvat, 1981:3-7.

4. Lebowitz PW, Ramsey FM, Savarese JJ, Ali HH. Potentiation of neuromuscular blockade in man produced by combination of pancuronium and etocurine or pancuronium and d-tubocurarine. Anaesth Analg 1980;59:604-9.

5. Pandit SK, Ferres FM, Gibson, Mirakhur RK. Time course of action on inaction of vecuronium and pancuronium. Anaesthesia 1986;41:151-154.

6. Torda TA. The “new” relaxants. A review of the clinical of pharmacology of atracurium and vecuronium. Anaesth Inten Care 1987;15:72-79.

7. Stenlake JB, Stenlake, JB, Waigh RD, Dewar GH, Coker GG. Atracurium: Conception and inception. Br J Anaesth 1983;55:3-10.

8. Miller RD, Rupp SM, Fisher DM, Cronolly R, Fahey MR, Sohn YT. Clinical Pharmacology of vecuronium and atracurium. Anesthesiology 1984;51:444-453.

9. Torda TA. Klonymus DH. The regional use of muscle relaxants. Anesthesiology 1966;27:6.

10. Engbaek J, Viby MJ. Can rocuronium replace succinylcholine in a rapid-sequence induction of anaesthesia? Act Anaesthesiol Scand 1999;43:1-3.

11. Whitford AM, Hone SW, O’Hare B, Magner J, Eustace P. Intra-ocular pressure changes following laryngeal mask airway insertion: a comparative study. Anaesthesia 1997;52:794-796.

12. Hunter JM. Adverse effects of neuromuscular blocking drugs. Br J Anaesth 1986;59:46-60.

13. Engbaeck J, Ording H, Sorensen B, Viby MJ. Cardiac effects of vecuronium and pancuronium during halothane anesthesia. Br J Anaesth 1983;55:501-5.

14. Neidhart PP, Champion P, Vogel J, et al. Comparison of pipecuronium with pancuronium on haemodynamic variables and plasma catecholamines in coronary artery bypass patients. Can J Anaesth 1994;41:469-74.

15. Savege TM. Blogg CE, Ross L, Lang M, Simpson BR. The cardio vascular effects of AH 8165. Anaesthesia 1973;28:253-261.

16. Deam RK, Soni N. Effects of pipecuronium and pancuronium on the isolated rabbit. Heart Br J Anaesth1989;62:287-289.

17. Stanley JC, Mirakhur RK. Stanley JC, Mirakhur RK. Comparative potency of pipecuronium bromide and pancuronium bromide. Br J Anaesth 1989;63:754-5.

18. Wierda J, Richardson FJ, Agoston S. Dose-response relation and time course of action of pipecuronium bromide in humans anesthetized with nitrous oxide and isoflurane, halothane, or droperidol and fentanyl. Anesth Analg 1989;68: 208-13.

19. Canga JC. Efecto del priming en la reducción de la latencia del pipecuronio, nuevo bloqueador neuromuscular no despolarizante. Rev Bras Anestesiol 2005;55:381-386.

20. Caldwell JE, Castagnoli KP, Canfell P C, Fahey MR, Lynam DP, Fisher Pipecuronium and pancuronium: comparison of pharmacokinetics and duration of action. Br J of Anaesthesia. 1988;61:693-7.

21. Foldes FF, Nagashima H, Nguyen HD, Duncalf D, Goldiner PL. Neuromuscular and cardiovascular effects of pipecuronium. Can J Anaesth 1990;37:549–55.