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Colegio de Medicina Interna de México.

2010, Number 3

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Med Int Mex 2010; 26 (3)

Lactic acidosis due to metformin

Carrillo ER, Sosa GJO

Language: Spanish
References: 31
Page: 276-280
PDF size: 176.33 Kb.


ABSTRACT

Background: Lactic acidosis associated with metformin has low prevalence and mortality of 30 to 50%. The aims of this paper is to present a case of lactic acidosis associated with metformin and to review the current concepts and treatment options of this entity.
Case: A 75-year-old patient with diabetes mellitus type 2 and renal failure treated with metformin. He was admitted with diarrhea, respiratory distress, dehydration, oliguria, altered state of alertness, anemia, hyperkalemia, hyperazoemia, lactic acidosis with lactate levels of 9.1 mmol/L. Management was based on support measures, hemodialysis and discontinuation of metformin with satisfactory evolution.
Conclusions: Lactic acidosis secondary to metformin should be suspected in patients who are treated with this medicine and who have risk factors such as liver and kidney failure, alcoholism and sepsis. Early diagnosis and timely treatment are essential to decrease mortality.


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