Carrillo ER, Carrillo CJR, Carrillo CLD

Language: Spanish
References: 49
Page: 372-378
PDF size: 398.05 Kb.

ABSTRACT

Statins are currently used for hyperlipidaemia control and considered useful for protection from cardiovascular events. In addition, there is increasing evidence for the potential use of statins in preventing and treating sepsis. Statins have been attributed anti-inflammatory and immunomodulatory pleiotropic effects. They inhibit the synthesis of products of mevalonate pathway such as isoprenoids and geranylgeranylpyrophosphate. In addition, they modify the intercellular interactions and the cellular chemotaxis of the immune system. Furthermore, statins reduce the release of cytokines and acute-phase proteins and demonstrate antioxidant properties. Having all these properties, statins have been suggested as an adjunct in the treatment of patients with sepsis. The majority of the existing evidence seems to support this hypothesis in different experimental models and clinic studies. There is a need for prospective studies and randomized controlled trials in order to draw a safe conclusion regarding the consideration of statins as useful complementary agents in the treatment of sepsis and infection

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