2008, Number 5
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Med Int Mex 2008; 24 (5)
Agranulocytosis wi th atypical react ive plasmocytosis induced by methimazole in a patient with hypertiroidism
León MF, Mateos THN, Caballero CR, Suárez OR, García VMA
Language: Spanish
References: 9
Page: 357-360
PDF size: 212.02 Kb.
ABSTRACT
Methimazole is the most common drug used to treat hyperthyroidism in Mexico. An unusual secondary effect is agranulocytosis, however reactive plasmocytosis is even more rare. We report a case in a young patient and possible mechanisms are discussed.
REFERENCES
Breier DV, Rendo P, Gonzalez J, Shilton G, et al. Massive plasmocytosis due to methimazole-induced bone marrow toxicity. Am J Hematol 2001;67:259-61.
McKenzie SB. Hepatología clínica. 2ª ed. México: El Manual Moderno, 2002;pp:337.
Godwin JE, Braden CD. Neutropenia. eMedicine [available online: http://www.emedicine.com/MED/topic1640.htm] Updated august 9, 2006.
Ruiz-Gil W, Tokumura TC, Ruiz-Rodríguez C. Severe reactive plasmocytosis and agranulocytosis associated with methimazol. Rev Med Hered 2005;16(2):158.
Rocca NJ, Valdivia CH, Arbañil HH, Loayza UN. Agranulocitosis inducida por metimazol: a propósito de tres casos. Rev Peru Endocr Metabol 2002;5(1-2):79-83.
Hodak SP, Huang C, Clarke D, Burman HD, et al. Intravenous methimazole in the treatment of refractory hyperthyroidism. Thyroid 2006;16(7):691-5.
Beauchesne MF, Shalansky SJ. Nonchemotherapy drug-induced agranulocytosis: a review of 118 patients treated with colony-stimulating factors. Pharmacotherapy 1999;19(3):299- 305.
Tajiri J, Noguchi S. Antithyroid drug-induced agranulocytosis: how has granulocyte colony-stimulating factor changed therapy? Thyroid 2005;15(3):292-7.
Andres E, Maloisel F. Idiosyncratic drug-induced agranulocytosis or acute neutropenia. Curr Opin Hematol 2008;15(1):15- 21.