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2010, Number 2

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Rev Mex Patol Clin Med Lab 2010; 57 (2)

Influenza: Recent advances in molecular virology and disease prevention

Carrada BT

Language: Spanish
References: 31
Page: 59-93
PDF size: 742.81 Kb.


ABSTRACT

Influenza viruses are Orthomyxoviridae which contain eight separate RNA-segments that encode 10 proteins, this explain why reassortement happens so often. If two different viruses co-infect the same cell an exchange of genes can easily take place yielding up to 256 different off-springs. Viruses type A are categorize by variation of two glycoprotein’s, hemagglutinin (HA) and neuraminidase (NA). NA attaches to sialic acid receptors and penetrates into host cell endosomic vesicles, then moves to the nuclease where RNA encodes messenger to produce virions. NA task is to enable new virions to separate from infected cell. This paper reviews recent advances in molecular structure functions of HA and NA, provided by crystallography, mass spectrophotometer, biochemical methods and the use of monoclonal antibodies, the new collected information may help to explain pathogen city-virulence and rapid transmission of A H1N1 porcine and A H5N1 avian circulating viruses, mechanisms of interspecies adaptation, and development of new antiviral drugs. Clinical research served to stress the importance of hand washing as the first line of prevention, the proper use of surgical masks and respirators, health experts have designated health clinical workers as a priority group to receive the protective vaccinations, to decrease chances of transmiting the flu-viruses to at-risk patients.


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