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2010, Number 1

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Rev Med Hosp Gen Mex 2010; 73 (1)

The analyis of the CYP1B1 gen shows a diminished frequency of the hyperactive variants in Mexican patients

González-Huerta LM, Messina-Baas OM, Chima-Galán C, Amancio-Chassin O, Lara-Huerta F, Cuevas-Covarrubia SA

Language: Spanish
References: 14
Page: 30-34
PDF size: 123.61 Kb.


ABSTRACT

Human cytochrome P450 1B1 is an important enzyme in the activation of diverse procarcinogens. CYP1B1 gene is polymorphic and hyperactive variants can lead to a higher susceptibility to estrogen-related cancers. Mexican population shows a lower incidence of this type of cancers in comparison with other western countries. In the present study we analyzed the frequency of five CYP1B1 polymorphic sites, specially the hyperactive variants Ala119Ser, Leu432Val and Asn453Ser to initially explore the possible relation between the lower incidence of estrogen-related cancer and the presence of these alleles in Mexican population. The genetic distribution of CYP1B1 variants was evaluated in 100 Mexican healthy subjects through genomic DNA sequencing analysis. The frequency of homozygous hyperactive variant Ala119Ser (23%) was higher than those reported in other populations. The frequencies of polymorphic variants 4326C›G (Leu432Val) and 4390A›G (Asn453Ser) (3% and 0%, respectively) were significantly lower than those observed in other populations except for Japanese population. The homozygous variant 4390A›G was not identified in our population. We concluded that CYP1B1 gene hyperactive variants are less frequent in the Mexican population than those reported in western populations.


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