Medrano-Palafox J, Baiza-Durán LM, Contreras-Rubio AY, Álvarez-Delgado J, Chávez-Villa K, Luca-Brown A, Urquides-Espinoza LG

Language: Spanish
References: 16
Page: 1-4
PDF size: 91.96 Kb.

ABSTRACT

Objective: To report the intraocular pressure of New Zealand albino rabbits measured with Goldman’s tonometer.Material and methods: One hundred twenty-five New Zealand albino rabbits were studied. The intraocular pressure measurements were carried out mornings and evenings. Mean ± standard deviation of the intraocular pressure and pressures measured mornings and evenings were calculated as well as intra-eye and inter-observer differences. Results: A total of 860 measurements were conducted with a pressure result of 9.0 ± 1.3 mmHg, a morning pressure of 9.0 ± 1.4 mmHg and an evening pressure of 9.1 ± 1.3 mmHg. Intra-eye differences were ≤ 2 mm Hg in 91% of the rabbits. Inter-observer differences were ≤3 mmHg in 98% of measurements resulting a Pearson’s correlation coefficient = 1. Conclusions: The normal intraocular pressure in New Zealand albino rabbits measured with Goldman’s tonometer were reported with minimal intra-eye and inter-observer differences.

REFERENCES

1. Lim KS, Wickremasinghe SS, Cordeiro MF, Bunce C, Khaw PT. Accuracy of intraocular pressure measurements in New Zealand white rabbits. Invest Ophthalmol Vis Sci 2005; 46(7): 2419-2423.

2. Abrams LS, Vitale S, Jampel HD. Comparison of three tonometers for measuring intraocular pressure in rabbits. Invest Ophthalmol Vis Sci 1996; 37(5):940-944.

3. Vareilles P, Conquet P, Le Douarec JC. A method for the routine intraocular pressure (IOP) measurement in the rabbit: range of IOP variations in this species. Exp Eye Res 1977; 24(4):369- 375.

4. Kaufman PL. Aqueous humor dynamics following total iridectomy in the cynomolgus monkey. Invest Ophthalmol Vis Sci 1979; 18(8):870-874.

5. Kaufman PL, Davis GE. "Minified" Goldman applanating prism for tonometry in monkeys and humans. Arch Ophthalmol 1980; 98(3):542-546.

6. Oltmanns MH, Samudre SS, Castillo IG y cols. Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action. J Ocul Pharmacol Ther 2008; 24(1):104-115.

7. Gabelt BT, Okka M, Dean TR, Kaufman PL. Aqueous humor dynamics in monkeys after topical R-DOI. Invest Ophthalmol Vis Sci 2005; 46(12):4691-4696.

8. Gabelt BT, Seeman JL, Podos SM, Mittag TW, Kaufman PL. Aqueous humor dynamics in monkeys after topical 8-iso PGE (2). Invest Ophthalmol Vis Sci 2004; 45(3):892-899.

9. Gabelt BT, Gottanka J, Lütjen-Drecoll E, Kaufman PL. Aqueous humor dynamics and trabecular meshwork and anterior ciliary muscle morphologic changes with age in rhesus monkeys. Invest Ophthalmol Vis Sci 2003; 44(5):2118-2125.

10. Gabelt BT, Millar CJ, Kiland JA, Peterson JA, Seeman JL, Kaufman PL. Effects of serotonergic compounds on aqueous humor dynamics in monkeys. Curr Eye Res 2001; 23(2):120- 127.

11. Cohan BE, Bohr DF. Measurement of intraocular pressure in awake mice. Invest Ophthalmol Vis Sci 2001; 42(11):2560- 2562.

12. Cohan BE, Bohr DF. Goldman applanation tonometry in the conscious rat. Invest Ophthalmol Vis Sci 2001; 42(2):340-342.

13. Tian B, Gabelt BT, Crosson CE, Kaufman PL. Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys. Exp Eye Res 1997; 64(6):979-989.

14. Green K. Techniques of intraocular pressure determination. Lens Eye Toxic Res 1990; 7(3-4):485-489.

15. Katz RS, Henkind P, Weitzman ED. The circadian rhythm of the intraocular pressure in the New Zealand White rabbit. Invest Ophthalmol 1975; 14(10):775-780.

16. Whitacre MM, Stein R. Sources of error with use of Goldman- type tonometers. Surv Ophthalmol 1993; 38(1):1-30.