2010, Number 2
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Rev Odont Mex 2010; 14 (2)
Immunoexpression of dendritic cells in clinically health and irreversible pulps
Figueiras MER, Cardiel NM, Jacinto ALF, Ballesteros VA, Chávez BE, García ALR, Hernández GJC
Language: Spanish
References: 19
Page: 85-90
PDF size: 400.90 Kb.
ABSTRACT
Defense reactions of the dentin/pulp complex involve a variety of biological systems; in which the immune system plays a main role. The identification of pulpal dendritic cells (DC) has generated research activities to know how an antigen can evoke a pulpal immune response. The purpose of this work was to make a quantification and observation of DC in healthy and irreversible clinical diagnosed pulp using HLA-DR marker. Immunohistochemical observations of healthy clinical pulps revealed a prominent paraodontoblastic distribution of CD. On the other hand on irreversible clinical pulps the number and distribution of CD was irregular in all the pulp tissue. That makes us suggest that the CD in dental pulp continue activating immunologic responses even on irreversible pulp process.
REFERENCES
Bergenholtz G. Pathogenic mechanisms in pulpal disease. J Endod 1990; 16: 98-101.
Pashley DH. Dynamics of the pulp-dentin complex. Crit Rev Oral Biol Med 1996; 7(2): 104-33.
Jontell M, Okiji T. Beregenholtz, immune defense mechanisms of the dental pulpa. Crit Rev Oral Biol Med 1998; 9: 1149-1153.
Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu et al. Immunology of dendritic cells. Ann Rev Immunol 2000; 18: 767-811.
Gerald B, Pier. Jeffrey B, Lyczak. Immunology, infection and immunity, edit. ASM press, Washington. CD. Chapter 1, 2 and 3.
Jontel M, Gunraj MN, Bergenholtz G, Immunocompetent cells in normal dental pulp. Criv Rev Oral Biol Med 1998: 179-200.
Jontell M, Eklöf C, Dahlgren U, Bergenholtz G, Difference in capacity between macrophages and dendritic cells from rat incisor pulp to provide signals to concanavalin-A-Stimulated T-lymphocytes. I Dent Res 1994; 72: 1056-1060.
Jontell M, Bergenholtz G, Scheynius A. Ambrose W. Dendritic cells and macrophages expressing class II antigens in the normal rat incisor pulp. J Dent Res 1998; 67: 1263-1266.
Ohshima H, Kawahara I, Maeda T, Takano Y. The relationship between odontoblast and immunocompetent cells during dentinogenesis in rat incisors: an immunohistochemical study using OX-6 monoclonal antibody. Arch Hitol Cytol 1994; 57: 435-447.
Ohshima H, Sato O, Kawahara I, Maeda T, Takano Y. Responses of immunocompetent cells to cavity preparation in rat molars: an immunohistochemical study using OX6-monoclonal antibody. Connecvt Tissue Res 1995; 32: 303-311.
Seltzer S, Bender IB. The pulp as connective tissue Lippincott Philadelphia. 1984: 78-104.
Czernielewski J, Vaigot P, Prunieras M. Epidermal Langerhans cells. A cycling cell population. J Invest Dermatol 1985; 84: 424-6.
Bergenholtz G, Knutsson G, Jontell M, Okiji T. Albumin flux across dentin of young human premolars following temporary exposure to the oral environment. In: Proceedings of the International Conference on dentin/pulp complex 1995 and the international meeting on clinical topics of dentin/pulp.
Roitt I, Brostoff J, Male D. Cell cooperation in the antibody response. Immunology, Fourth Edition. London: Mosby, 1996; 15: 464-8.
Jontell M, Gunraj MN, Bergenholtz G. Immunocompetent cells in normal dental pulp. J Dent Res 1987; 66: 1149-1153.
Kuplec-Weglinski JW, Austyn JM, Morris PJ. Migration patterns of dendritic cells in the mouse traffic from the blood, and the T –cell dependent and independent entry to lymphoid tissues. J Exp Med 1988; 167: 632-45.
Massler M. Pulpal reactions to dental caries. Int Dent 1967; 17: 441-460.
Heyerass KL, Kvinnsland L. Tissue pressure and blood flow in pulpal inflammation. Proc Finn Dent Soc 1992; 88(Suppl 1): 393-401.
Heyerass KI, Lacobsen EB, Fristad I, Raab WH-M. Vascular and immunoreactive nerve fibre reactions in the pulp after stimulation and denervation In: Proceedings of the International Conference on Dentin/Pulp Complex 1995 and the International meeting on clinical Topics of dentin/pulp complex: Quintessence. 1996: 162-168.