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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2001, Number 3

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Alerg Asma Inmunol Pediatr 2001; 10 (3)

Gastroesophageal reflux and recent diagnosis asthma in children

Ramírez-Mayans J, Mata-Rivera N, Cervantes-Bustamante R, Zárate-Mondragón F, Munguía-Vanegas P, López-Pérez G, Orozco-Martíne Sz, Huerta-López J

Language: Spanish
References: 26
Page: 77-81
PDF size: 201.17 Kb.


ABSTRACT

Asthma world prevalence in children is estimated between 1.6% to 36.8% in contrast to gastroesophageal reflux (GER) which presents a value of 8%. GER greater prevalence in children suffering from chronic respiratory disease raises the possibility of a casual association between asthma and GER. The objective of this study was to determine GER prevalence in children suffering from recently diagnosed and to know their response to ranitidine treatment. Methods: 50 children, with ages ranging from 6 months to 5 years, were studied. They were practiced continuous intraesophageal Hp determination during 24 hours. Patients were divide into two groups: Group 1 with GER was treated with ranitidine in a 8 mg/kg/day dose, and Group 2 without GER. Results: Average age was 23.78 months ± 16.29. 12/50 children presented GER (Group 1). Boyle variables got normalized in most of the patients 4 weeks after the treatment. Only 2/12 children belonging to Group 1 presented regurgitation . Conclusions: Silent GER in children suffering from asthma must opportunely be diagnosed to lead it to its proper management.


REFERENCES

  1. ISAAC. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema. Lancet 1998; 351: 1225-32.

  2. Dinwiddie R. The diagnosis and management of pediatric respiratory disease. Longman, Singapore 1990.

  3. Dawson D, Horobin G, Illsley R, Mitchell R. A survey of childhood asthma in Aberdeen. Lancet 1969; 1: 827-30.

  4. Schindlbeck NE, Heinrich C, König A, Derndorfer A, Page F, Müller-Lissner SA. Optimal thresholds, sensitivity and specificity of long-term pH metry for the detection of gastroesophageal reflux disease. Gastroenterology 1985; 93: 85-90.

  5. Cucchiara S, Staiano A, Romaniello G, Capobianco S, Aurichio S. Antacids and cimetidine treatment for gastroesophageal reflux and peptic oesophagitis. Arch Dis Child 1984; 59: 842-7.

  6. Dimand RJ. Use of H2-receptor antagonist in children. DICP 1990; 24 (suppl 11): S42-6.

  7. Mal F, Delchier JC. Interactions pharmacinétques des antagonistes des récepteurs H2 de l’istamine: mecanismes et implications cliniques. Gastroenterol Clin Biol 1987; 1: 387-98.

  8. Lambert J, Mosbassalah M, Grand R. Efficacy of cimetidine, for gastric acid suppression in pediatric patients. J Pediatr 1992; 120: 474-8.

  9. Boyle T. Gastroesophageal reflux in the pediatric patient. Gastroenterol Clin North Am 1989; 18: 315-37.

  10. Vandenplas Y. Asthma and Gastroesophageal reflux. J Pediatr Gastroenterol Nutr 1997; 24: 89-99.

  11. Blecker U, de Pont SM, Hauser B, Chouraqui JP, Gottrand F, Vandenplas Y. Role of occult gastroesophageal reflux in chronic pulmonary disease in children. Acta Gastroenterol Belg 1995; 58: 348-52.

  12. Curci M, Dibbins A. Gastroesophageal reflux in children: an underrated disease. Am J Surg 1982; 143: 413-6.

  13. Vandenplas Y. Diagnosis of gastro-esophageal reflux. Clin Rev Allergy 1991; 8: 443-55.

  14. Forget PP, Arends JW. Cow’s milk protein allergy and gastro-esophageal reflux. Eur J Pediatr 1985; 144: 298-301.

  15. Dennish GW, Castell DO. Inhibitory effect of smoking on the lower esophageal sphincter. N Engl J Med 1971; 284: 1136-7.

  16. Stanciu C, Bennett JR. Smoking and gastro-esophageal reflux. BMJ 1972; 3: 793-5.

  17. Eryer PE, Haymond MW, Santiago JV, Shah SD. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. N Engl J Med 1976; 295: 573-7.

  18. Rattan S, Goyal RK. Effect of nicotine on the lower esophageal sphincter. Gastroenterology 1975; 69: 154-9.

  19. Allen JL, Wohl MEB. Pulmonary function in older children and young adults with gastroesophageal reflux. Clin Pediatr 1986; 25: 541-6.

  20. Piepsz A, Ham HR. Nuclear medicine in the evaluation of gastrointestinal structure and functions in children. Front Gastrointest Res 1989; 15: 213-32.

  21. Hopper AO, Grill BB. Does gastroesophageal reflux detected by esophageal pH monitoring predict aspiration in preterm mechanically ventilated infants? [abstract]. J Pediatr Gastroenterol Nutr 1994; 19: 333.

  22. Malfroot A. Gastroesophageal reflux and unexplained chronic respiratory disease in infants and children. Pediatr Pulmonol 1987; 3: 208-13.

  23. Christie DI, O’Grady LR, Mack DV. Incompetent lower esophageal sphincter and gastroesophageal reflux in recurrent acute pulmonary disease of infancy and childhood. J Pediatr 1978; 93: 23-7.

  24. Kjellen G. Bronchial obstruction after esophageal acid perfusion in asthmatics. Clin Physiol 1981; 1: 285-92.

  25. Davis RS, Larsen GL, Grunstein MM. Respiratory response to intraesophageal acid infusion in asthmatic children during sleep. J Allergy Clin Immunol 1983; 72: 393-8.

  26. Spaulding HS, Mansfield LE, Stein MR. Further investigation of the association between gastroesophageal reflux and bronchoconstriction. J Allergy Clin Immunol 1982; 69: 516-21.




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