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ISSN 1405-1699 (Print)
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2000, Number 6

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Alerg Asma Inmunol Pediatr 2000; 9 (6)

Exhaled nitric oxide: A non-invasive method to assess airways inflammation in asthmatics

Ortega HG

Language: English
References: 31
Page: 191-194
PDF size: 202.22 Kb.


ABSTRACT

The aim of this article is to summarize the best evidence available about the applications of nitric oxide (NO) to evaluate airway inflammation. Airway inflammation plays a fundamental role in asthma and is considered to be a major cause for exacerbation and persisting structural changes of the airways. Evaluation of airway inflammation is an important sign for investigating the underlying mechanisms of asthma. Measurement of airways inflammation may reveal diseased airways not detectable by symptoms, clinical examination, lung function or airways hyperresponsiveness. Airways inflammation has been measured in secretions and biopsies obtained during flexible bronchoscopy, but these methods are too invasive and not appropriate for monitoring airways inflammation repeatedly. Over the last few years research has looked into other less invasive alternatives such as induced sputum and evaluation of exhaled NO (ENO) as markers of inflammation. Using measurement of ENO as an index of lung inflammation remains a complex matter, as it is affected by many biological and technical factors other than airways inflammation. However, within limits, it still offers the promise of being a quick and non-invasive approach for evaluation of inflammation in subjects with asthma.


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