Ramírez-Mayans J, Cervantes-Bustamante R, Mata-Rivera N, Zárate-Mondragón F, Munguía-Vanegas P, López-Pérez G, Orozco-Martínez S

Language: Spanish
References: 0
Page: 188-190
PDF size: 162.42 Kb.

ABSTRACT

Introduction: Worldwide asthma prevalence is 10% and of GER 8%, therefore coexistence seems to be 1%.
Aim: To determine changes in a continuous 24 h intraesophageal pH monitoring test basal and after 4 weeks post treatment with ranitidine in recently diagnosed asthma and GER patients.
Methods: 50 children with recently diagnosed asthma according to The American Academy of Asthma Allergology and Immunology criteria, were studied. A basal continuous 24 h intraesophageal pH monitoring test with Digitrapper Mark III equipment and antimony catheter was performed. Children with positive study according to Boyle’s criteria were included and ranitidine treatment (8 mg/kg/day) was initiated. A continuous 24 h intraesophageal pH-monitoring test was performed at 4, 12 and 24 weeks until normalization (negative test).
Results: 12/50 patients had pathologic GER according to the pH test. Mean age was 23.86 ± 16.29 months, 34 males (68%). Only 2/12 (17%) had gastrointestinal manifestations consisting in vomiting. In 9/12 children, the pH test was normalized at 4 weeks, 2 patients normalized at 3 months and 1 until 6 months.
Conclusion: Pathologic GER frequency associated with recently diagnosed asthma was 24%. 83.3% of these children had occult GER. Ranitidine treatment should last at least 3 months.