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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2000, Number 5

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Alerg Asma Inmunol Pediatr 2000; 9 (5)

Wegener’s granulomatosis

Alvarado PN, Ambriz MMJ

Language: Spanish
References: 22
Page: 174-179
PDF size: 326.84 Kb.


ABSTRACT

Wegener’s Granulomatosis (WG) was first described in the 1930’s and since that time, the disorder has been recognized as a distinct type of systemic vasculitis. It is a disease of unknown etiology that is characterized by the clinicopathologic complex of necrotizing granulomatous vasculitis or the upper and lower respiratory tract, glomerulonephritis, and variable degrees of small vessel vasculitis. The NIH experience suggests that WG affects both sexes equally, occurs in patients of all ages, and is more commonly seen in white patients. Recently, antineutrophil cytoplasmic antibodies (ANCA) have been reported to be both sensitive and specific for Wegener’s Granulomatosis.
Corticosteroids in combination with cyclophosphamide are extremely effective therapy for Wegener’s Granulomatosis.


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