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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

1999, Number 2

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Alerg Asma Inmunol Pediatr 1999; 8 (2)

Immunological disorders and the renewed interest on thalidomide.

Cejudo RC

Language: Spanish
References: 57
Page: 49-56
PDF size: 389.55 Kb.


ABSTRACT

Thalidomide was synthesized in 1954 in East Germany. Preliminary studies showed a safe, non-teratogenic drug. It was prescribed during the first trimester of pregnancy as an antiemetic, sedative and hypnotic drug. Later on its use was related to severe limb defects and devastating teratogenic side effects in thousand of newborn. The impact on the medical community and the lack of other known clinical applications, made that it was banished for years. Then Sheskin in 1965, using this drug as a sedative in patients with lepromatous erythema nodosum noticed that the skin lesions were dramatically improved. It is now used to treat different dermatological and immunological disorders. Thalidomide is an anti-inflammatory and immunomodulatory drug with no immunosuppressive effects. It acts on fagocytic and endothelial cells but it has no direct influence on T lymphocytes. The use of thalidomide has two risks: First, its known teratogenic potential then an adequate birth control method is imperative when used in fertile women. And second, the potential risk of peripheral polyneuropathy. Thalidomide has a clear immunomodulatory potential, but a better understanding of its mechanism of action, teratogenicity and neurotoxicity is needed before we can recommend its widespread use as safe.


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