Ordaz SMI, Zapata BP, Trejo ÁL, Tamez GRS, Rodríguez PC, Rivera MLG

Language: Spanish
References: 27
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ABSTRACT

In Mexico, as in the rest of the world AIDS has become a serious public health. The HIV-1 has the ability to infect different cell types as T cell, macrophages and dendritic cell (DC). These cells, are crucial in the defense against infectious agents and play a major role in viral pathogenesis, DC are one of the first cell types infected in peripheral mucosal and are distributed in the vaginal, ectocervical and anal mucosa; allowing contact with HIV-1 during sexual exposure. Recently, a type II integral membrane protein termed DC-SIGN has been shown to mediate binding of HIV-1 to DC. This receptor, appears to be responsible for ability of DC to efficiently mediate infection of T cell, It has been proposed that HIV-1 uses DC as carriers allowing the virus to access lymphoid tissues, the major site of replication, consequently they may contribute to the pathogenesis of HIV-AIDS.

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