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2001, Number 3

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Salud Mental 2001; 24 (3)

La ontogenia del sistema nervioso: ¿Clave del envejecimiento y de la plasticidad sináptica? 'Existe un patrón: la clave está en entenderlo'

Calderón AF, López CAM

Language: Spanish
References: 57
Page: 10-16
PDF size: 118.70 Kb.


ABSTRACT

Up to now, the cellular and molecular bases of aging and neural plasticity remain unknown. This paper analyzes this problem from a developmental point of view, taking into consideration the coexistence of different cellular microenvironments coexisting in the nervous system (NS), predetermined by specific developmental pathways, which directly influence the nervous function in the organism. The developmental changes in the subunit composition of the NMDA subtype of glutamate receptors is analyzed following this approach, and changes demonstrated in these structures are compared with those observed in receptors from differentiated nervous tissues as a consequence of plastic phenomena. Finally, based on the results of this analysis we postulate an hypothesis relating the developmental changes to the Alzheimers disease.


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