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2009, Number 4

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Med Crit 2009; 23 (4)

Sodium selenite as restart balance inflammatory drugs in septic patients

Montoya GC, Hernández LA, Villalobos SJA, Olvera GC, Aguirre SJ, Franco GJ

Language: Spanish
References: 25
Page: 199-205
PDF size: 94.23 Kb.


ABSTRACT

Introduction: Sepsis is not only a high inflammatory state, it is an abnormal inflammatory response. High doses of sodium selenite could be this searched medication.
Purpose: To investigate possible selenite therapeutic uses in the induced sepsis inflammatory process.
Methods: A prospective, placebo-controlled, randomized, double-blind study was performed with an intention-to-treat analysis in septic patients.
Results: 68 patients were included (placebo, n = 34; selenium, n = 34). Patients received selenium (1,000 µg on the first day, 500 µg second day and 200 µg on de following days). Endpoint was decrease SOFA; APACHE II; Mortality.
Discussion: Continuous infusion of selenium as sodium selenite improve the clinical course in septic shock patients. Mortality rates did not significantly differ between groups.


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