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2009, Number 2

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Vet Mex 2009; 40 (2)

Histological and immunophenotypic study of canine lymphoma in the center of Mexico

Álvarez BFJ, Aburto FE, Aristi UG, Chávez GG

Language: English/Spanish
References: 31
Page: 141-155
PDF size: 478.86 Kb.


ABSTRACT

Immunophenotype constitutes an important factor in the prognosis of canine lymphoma. It has been demonstrated that dogs with B-cell lymphomas have a longer life span than those with T-cell lymphomas. CD3 and CD79a antigens are the most common markers used for the immunohistochemical determination of T-cell and B-cell on formalin-fixed paraffin wax-embedded canine lymphoma tissues. This study describes the morphological and immunophenotypic characteristics of 31 cases of lymphoma in Mexico, obtained from files of the Pathology Department of Veterinary Medicine and Animal Husbandry Faculty of the National Autonomous University of Mexico. The National Cancer Institute-Working Formulation (NCI-WF) classification system was used for the histological classification. Fourteen cases (45.16%) were B cell origin, 15 cases (48.39%) were T-cell origin and 2 cases (6.45%) presented an indeterminate origin. Histopathological diffuse large cell lymphoma (DL) was the most common found (38.71%), followed by lymphocytic (DSL), immunoblastic (IB), intermediate and high-grade lymphomas represented 77.42% of the cases. In this study there was higher prevalence of T-cell lymphoma. The results in this work could indicate prevalent differences in the immunophenotype of the canine lymphoma in Mexico compared with other geographical areas.


REFERENCES

  1. TESKE E. Canine Malignant Lymphoma: A Review and Comparisson with Human Non-Hodgkin’s Lymphoma. Vet Q 1994;16: 209-219.

  2. COUTO CG. Canine Lymphomas: Something Old, Something New. Compend Cont Ed Pract Vet 1985; 7: 291-302.

  3. HAHN KA, RICHARDSON RC, HAHN EA, CRISMAN CL. Diagnostic and Prognostic Importance of Chromosomal Aberrations Identified in 61 Dogs with Lymphosarcoma. Vet Pathol 1994; 31:528-540.

  4. MADEWELL BR. Canine Lymphoma. Vet Clin North Am: Small Anim Prac 1985; 15: 709-722

  5. GREENLEE PG, FILIPPA DA, QUIMBY FW, PATNAIK AK, CALVANO SE, MATUS RE et al. Lymphomas in dogs. A morphologic, immunologic, and clinical study. Cancer 1990; 66:480-490.

  6. CARTER RF, VALLI VE, LUMSDEN JH. The Cytology, Histology and Prevalence of Cell Types in Canine Lymphoma Classified According to the National Cancer Institute Working Formulation. Can J Vet Res 1986; 50:154-164.

  7. MORRIS JS, DUNN JK, DOBSON JM. Canine Lymphoid Leukemia and Lymphoma with Bone Marrow Involvement: A Review of 24 Cases. J Small Anim Practice 1993; 34:72-79

  8. DOBSON JM, BLACKWOOD LB, MCINNES EF, BOSTOCK DE, NICHOLLS P, HOATHER TM et al. Prognostic Variables in Canine Multicentric Lymphosarcoma. J Small Anim Pract 2001; 42: 377-384.

  9. PAGE R. Canine and Feline Lymphoma: Review of Prognostic Factors and Treatment Options. 26th World Congress Proceedings of the World Small Animal Veterinary Association; 2001 August 8-11; Vancouver, British Columbia, Canada. Vancouver, British Columbia, Canada: WSAVA, 2001: 546-548.

  10. RASKIN RE, FOX LE. An Interim Analysis of Geographic Differences in Morphology and Immunophenotype from 138 Cases of Canine Lymphoma. Mid-year Conference Proceedings of the 22nd Annual Conference of the Veterinary Cancer Society; 2002 April 11-14; Galena Illinois USA. Galeana Illinois USA: VCS, 2002: 11.

  11. NATIONAL CANCER INSTITUTE. The Non-Hodgkin´s Lymphoma Pathologic Classification Project. National Cancer Institute Sponsored Study of Classifications of Non-Hodgkin´s Lymphomas: Summary and Description of a Working Formulation for Clinical Usage. Cancer 1982; 49: 2112-2135.

  12. RUSLANDER D, MOORE AS, GLIATTO JM, L’HEUREUX D, COTTER SM. Cytosine Arabinoside as a Single Agent for the Induction of Remission in Canine Lymphoma. J Vet Inter Med 1994; 8:299-301.

  13. FERRER L, FONDEVILA D, RABANAL R, TARRES J, RAMIS A. Immunohistochemical detection of CD3 Antigen (Pan T Marker) in Canine Lymphomas. J Vet Diagn Invest 1993; 5:616-620.

  14. FOURNEL-FLEURY C, MAGNOL JP, BRICAIRE P, MARCHAL T, CHABANNE B, DELVERDIER A et al. Cytohistological and Immunological Classification of Canine Malignant Lymphomas: Comparison with Human Non- Hodgkin’s Lymphomas. J Comp Path 1997; 117:35-59.

  15. TESKE E, WISMAN P, MOORE PF, VAN HEERDE P. Histologic classification and immunophenotyping of canine non-Hodgkin's lymphomas: unexpected high frequency of T cell lymphomas with B cell morphology. Exp Hematol 1994; 22:1179-1187.

  16. BURNETT RC, VERNAU W, MODIANO JF, OLVER CS, MOORE PF, AVERY AC. Diagnosis of Canine Lymphoid Neoplasia Using Clonal Rearrangements of Antigen Receptor Genes. Vet Pathol 2003; 40:32-41.

  17. KOSAREK CE, KISSEBERTH WC, KOCIBA GJ. Use of Microarrays for Analysis of Canine Lymphoma. Proceedings of the 22nd Annual Conference of the Veterinary Cancer Society; 2002 april 11-14, Galena Illinois USA. Galeana Illinois USA: VCS, 2002:22.

  18. CANIATTI M, ROCCABIANCA P, SCANZIANI E, PALTRINIERI S, MOORE PF. Canine Lymphoma: Immunocytochemical Analysis of Fine-needle Aspiration Biopsy. Vet Pathol 1996; 33:204-212.

  19. FISHER DJ, NAYDAN D, WERNER LL, MOORE PF. Inmunophenotyping Lymphomas in Dogs: A Comparison of Results From Fine Needle Aspirate and Needle Biopsy Samples. Vet Clin Path 1995; 24:118-123.

  20. VAIL DM, MACEWEN EG, YOUNG KM. Canine Lymphoma and Lymphoid Leukemias. In: WITHROW SJ, MACEWEN EG, editors. Small Animal Clinical Oncology. 3a ed. Philadelphia, EUA: WB Saunders Company, 2001: 558-590.

  21. MILNER RJ, PEARSON J, NESBIT JW, CLOSE P. Immunophenotypic Classification of Canine Malignant Lymphoma on Formalin-Fixed Paraffin Wax-Embedded Tissue by Means of CD3 and CD79a Cell Markers. Onderstpoort J Vet Res 1996; 63:309-313.

  22. VALLI VE, JACOBS RM, PARODI AL, VERNAU W, MOORE PF. Histological Classification of Hematopoietic Tumors of Domestic Animals. Washington DC, USA: Armed Forces Institute of Pathology, 2002.

  23. KELLER ET. Immune-Mediated Disease as a Risk Factor for Canine Lymphoma. Cancer 1992; 70: 2334-2337.

  24. DAY MJ. Immunophenotypic Characterization of Cutaneous Lymphoid Neoplasia in the Dog and Cat. J Comp Path 1995; 112: 79-96.

  25. VERNAU B, MOORE P. Immunophenotyping in the Dog. Vet Cancer Soc Newsl 2001; 25:1-10.

  26. KIUPEL M, TESKE E, BOSTOK D. Prognostic Factors for Treated Canine Malignant Lymphoma. Vet Pathol 1999; 36:292-300.

  27. TESKE E. Prognostic Factors for Malignant Lymphoma in the Dog: an Update. Vet Q 1994;16:29-31.

  28. THOMAS R, SMITH KC, GOULD R, GOWER SM, BINNS MM, BREEN M. Molecular Cytogenetic Analysis of a novel High-grade Canine T-Lymphoblastic Lymphoma Demonstrating Co-expression of CD3 and CD79a Cell Markers. Chromosome Res 2001; 9:649-657.

  29. ABBAS AK, LICHTMAN AH, POBER JS. Maduración de los linfocitos B y expresión de los genes de las inmunoglobulinas. En: ABBAS AK, LICHTMAN AH, POBER JS, editores. Inmunología Celular y Molecular. 3ª ed. Madrid (España): Ed. Interamericana-McGraw Hill, 1999: 71-101.

  30. VERNAU W, MOORE PF. An immunophenotypic study of canine leukemias and preliminary assessment of clonality by polymerase chain reaction. Vet Immunol Immunopathol 1999; 69:145-164.

  31. ALIZADEH AA, EISEN MB, DAVIS RE, LOSSOS IS, ROSENWALD A, BOLDRICK JC et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000: 403:503-511.




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