Martínez ÁJC, Arrazola GA

Language: Spanish
References: 17
Page: 38-42
PDF size: 145.29 Kb.

ABSTRACT

In this article, we describe the clinical impact of HLA system in hematopoietic stem cell transplantation, because HLA molecules provide molecular basis for immunologic response. Hematopoietic stem cell transplantation can provide curative therapy for patients with hematologic malignancies, marrow failure states, severe immunodeficiences. Unfortunately, only 25 to 30% of patients will have a suitable HLA genotypically identical sibling donor available to facilitate transplant therapy thus they have to consider unrelated HLA-matching donors. Histocompatibility testing plays an important role in the selection of bone marrow donors for transplantation. Recently, the techniques involving DNA analysis are used, such as PCR-SSP and PCR-SSOP and others. This techniques give a correct assignment of HLA alleles.

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