medigraphic.com
Anales de la Sociedad Mexicana de Oftalmología y Archivos de la Asociación Para Evitar la Ceguera en México

2009, Number 4

<< Back Next >>

Rev Mex Oftalmol 2009; 83 (4)

Hallazgos estromales in vivo en pacientes operados de PRK con el uso de mitomicina-C

Ramírez-Fernández M, Hernández-Quintela E, Naranjo-Tackman R

Language: Spanish
References: 21
Page: 206-208
PDF size: 123.61 Kb.


ABSTRACT

Purpose: To compare the post-PRK stromal findings in eyes treated with mitomycin-C vs. without mitomicyn-C, by using confocal microscopy.
Methods: 20 eyes of 10 patients underwent PRK, 0.02% mitomycin-c was applied for 60 seconds in every left eye after stromal laser ablation. Confocal microscopy was done one week after surgery.
Results: Corneal epithelium was normal in 100% of the post-operatory corneas. Activated keratocytes were found within 56.7 ± 17.31µ of stromal depth in right eyes and 30.9 ± 13.74 µ (p ‹ 0.05) in left eyes (eyes treated with mitomycin-C) at 1 week after surgery.
Conclusion: Confocal microscopy findings after PRK in eyes treated by using mitomycin-C showed less stromal depth with activated keratocytes one week after surgery.


REFERENCES

  1. Steinert RF, Bafna S. Surgical correction of moderate myopia: which method should you choose? II. PRK and LASIK are the treatments of choice. Surv Ophthalmol 1998; 43:157-179.

  2. Ramirez-Florez S, Maurice DM. Inflammatory cells, refractive regression, and haze after excimer laser PRK. J Refract Surg 1996; 12:370-381.

  3. El-Agha MS, Johnston EW, Bowman RW, Cavanagh HD, Mc- Culley JP. Excimer laser treatment of spherical hyperopia: PRK or LASIK? Trans Am Ophthalmol Soc 2000; 98:59-66; discussion 66-69.

  4. Hoste AM, Goes FJ. Haze stage 3 after myopic photorefractive keratectomy (PRK) with the Meditec excimer laser. Bull Soc Belge Ophtalmol 1993; 249:55.

  5. Chang SS, Maurice DM, Ramirez-Florez S. Quantitative measurement of corneal haze after myopic PRK. J Refract Surg 1996; 12:412-416.

  6. Raviv T, Majmudar PA, Dennis RF, Epstein RJ. Mytomycin-C for post-PRK corneal haze. J Cataract Refract Surg 2000; 26:1105-1106.

  7. Shortt AJ, Allan BD. Photorefractive keratectomy (PRK) versus laser-assisted in-situ keratomileusis (LASIK) for myopia. Cochrane Database Syst Rev 2006:CD005135.

  8. O’Doherty M, Kirwan C, O’Keeffe M, O’Doherty J. Postoperative pain following epi-LASIK, LASEK, and PRK for myopia. J Refract Surg 2007; 23:133-138.

  9. Alio JL, Ortiz D, Muftuoglu O, Garcia MJ. Ten years after Photorefractive Keratectomy (PRK) and Laser In Situ Keratomileusis (LASIK) for Moderate to High Myopia (Control-Matched Study). Br J Ophthalmol 2008.

  10. Van de Pol C, Greig JL, Estrada A, Bissette GM, Bower KS. Visual and flight performance recovery after PRK or LASIK in helicopter pilots. Aviat Space Environ Med 2007; 78:547-553.

  11. Ivarsen A, Fledelius W, Hjortdal J. Three-year Changes in Epithelial and Stromal Thickness after PRK or LASIK for High Myopia. Invest Ophthalmol Vis Sci 2009.

  12. Kim TI, Lee SY, Pak JH, Tchah H, Kook MS. Mitomycin C, ceramide, and 5-fluorouracil inhibit corneal haze and apoptosis after PRK. Cornea 2006; 25:55-60.

  13. Netto MV, Chalita MR, Krueger RR. Corneal haze following PRK with mitomycin C as a retreatment versus prophylactic use in the contralateral eye. J Refract Surg 2007; 23:96-98.

  14. Erie JC, Patel SV, McLaren JW y cols. Effect of myopic laser in situ keratomileusis on epithelial and stromal thickness: a confocal microscopy study. Ophthalmology 2002; 109:1447-1452.

  15. Ramirez M, Hernandez-Quintela E, Sanchez-Huerta V, Naranjo-Tackman R. Confocal microscopy of corneal flap microfolds after LASIK. J Refract Surg 2006; 22:155-158.

  16. Ramirez M, Hernandez-Quintela E, Naranjo-Tackman R. A comparative confocal microscopy analysis after LASIK with the IntraLase femtosecond laser vs Hansatome microkeratome. J Refract Surg 2007; 23:305-307.

  17. Vesaluoma MH, Peraz-Santoja JJ, Linna TU, Petroll WM y cols. Confocal microscopy after myopic LASIK. Invest Ophthalmol Vis Sci 1999; 40 (ARVO abstract): S897.

  18. Mitooka K, Ramirez M, Maguire LJ y cols. Keratocyte density of central human cornea after laser in situ keratomileusis. Am J Ophthalmol 2002; 133:307-314.

  19. Kauffmann T, Bodanowitz S, Hesse L, Kroll P. Corneal reinnervation after photorefractive keratectomy and laser in situ keratomileusis: an in vivo study with a confocal videomicroscope. Ger J Ophthalmol 1996; 5:508-512.

  20. Lee BH, McLaren JW, Erie JC, Hodge DO, Bourne WM. Reinnervation in the cornea after LASIK. Invest Ophthalmol Vis Sci 2002; 43:3660-3664.

  21. Linna TU, Perez-Santonja JJ, Tervo KM, Sakla HF, Alio y Sanz JL, Tervo TM. Recovery of corneal nerve morphology following laser in situ keratomileusis. Exper Eye Research 1998; 66:755-763.




2020     |     www.medigraphic.com