Barrera-Pérez MA, Rodríguez-Félix ME, Guzmán-Marín E, Zavala-Velázquez J, Dumonteil E

Language: Spanish
References: 32
Page: 224-230
PDF size: 50.69 Kb.

ABSTRACT

Introduction. Trypanosoma cruzi infects a large variety of hosts, and produces variable clinical manifestations in humans. The differences in pathogenicity are thought to be directly related to the genetic heterogeneity of the parasite, which implies that strains from distinct regional areas should be characterised to understand the epidemiology and clinical outcome of the infection. The in vivo behaviour of three strains from Yucatan, Mexico (H4, H5, H10), is thus reported here for the first time. Material and Methods. Strains H4 and H5 were isolated from patients with severe pathologies, whereas strain H10 was avirulent Results. Experimental infection of NIH mice with strain H4 resulted in high parasitemia (1.04 x 10⁷ circulating parasite/mL) and tissue invasion, leading to a 50% survival. Strains H5 and H10 produced lower parasitemia (6.10 x 10⁶ and 1.29 x 10⁶ circulating parasite/mL), very limited tissue invasion, and 92% of infected mice survived. Discussion. We conclude that these strains show a virulence comparable to strains from other regions, but that their biological behaviour failed to directly correlate with known genetic markers.

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